Catechol-functionalized Coatings for Cardiovascular Medical Devices

用于心血管医疗器械的儿茶酚功能化涂层

• 批准号: 7671113
• 负责人: Kristin S Taton
• 金额: $ 9.98万
• 依托单位: INNOVATIVE SURFACE TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-15 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7671113
• 关键词: Adherence; Adhesions; Arteries; Biocompatible; Biocompatible Materials; Blood; Caliber; Cardiovascular system; Catechols; Catheters; Cell Adhesion Molecules; Coagulation Process; Deposition; Development; Devices; Docking; Ethylene Glycols; Evaluation; Fibrin; Friction; Goals; Government; Hand; Health; Hydrogels; Industry; Injury; Knowledge; Left; Maleimides; Medical; Medical Device; Methodology; Methods; Mussels; Oceans; One-Step dentin bonding system; Operative Surgical Procedures; Organic solvent product; Pain; Patients; Persons; Phase; Polyethylene Glycols; Polymers; Post-Translational Protein Processing; Povidone; Procedures; Property; Proteins; Pyrrolidinones; Research; Safety; Shipping; Ships; Silicones; Small Business Innovation Research Grant; Staining method; Stainless Steel; Stains; Surface; System; Techniques; Technology; Teflon; Testing; Time; Tissues; Titanium; Touch sensation; Tyrosine; Water; Work; adhesive protein (mussel); base; covalent bond; design; ethylene glycol; flexibility; improved; innovation; interfacial; monomer; next generation; novel; novel strategies; polyacrylamide; polybutyl methacrylate; public health relevance; surface coating

DESCRIPTION (provided by applicant): This project is designed to develop novel catechol-functionalized polymers for medical device coatings with increased lubricity. Catechols have been shown to be key components in the adhesive proteins that mussels secrete to attach to underwater surfaces. The catechol has a number of different non-covalent bond interactions which serve to increase adherence of catechol-functionalized molecules to both organic and inorganic substrates. This ability will be utilized to create coatings that adhere to previously difficult-to-coat medical device materials such as silicone, PEBAX-72 and Teflon, opening the way to enhanced device properties for these materials. Catechols will be incorporated by synthesizing a catechol monomer and copolymerizing with vinyl pyrrolidone, a commonly used hydrogel coating for increasing the slipperiness of a coating. While catechols have been previously attached to other polymers, they have been limited primarily to poly(ethylene glycol). The innovation in this proposal lies in the development of catechol-functionalized polymers for improved lubricity coatings for medical devices. PUBLIC HEALTH RELEVANCE: This proposal will develop coatings for cardiovascular medical devices to increase slipperiness and compatibility with the blood. It targets specific materials used in the device fabrication which are difficult to coat with a novel approach inspired by mussels. These mussel-inspired coatings should allow easier insertion of medical devices with less tissue injury and pain. Improved medical devices will improve patient comfort and health.

描述（由申请人提供）：该项目旨在开发用于医疗器械涂层的新型儿茶酚官能化聚合物，以提高润滑性。儿茶酚已被证明是贻贝分泌的附着在水下表面的粘附蛋白的关键成分。儿茶酚具有许多不同的非共价键相互作用，这些相互作用有助于增加儿茶酚官能化分子对有机和无机基材的粘附。这种能力将用于创建粘附在以前难以涂覆的医疗器械材料（例如有机硅、PEBAX-72 和特氟隆）上的涂层，从而为增强这些材料的器械性能开辟了道路。儿茶酚将通过合成儿茶酚单体并与乙烯基吡咯烷酮共聚而加入，乙烯基吡咯烷酮是一种常用的水凝胶涂料，用于增加涂料的光滑性。虽然儿茶酚以前已与其他聚合物连接，但它们主要限于聚乙二醇。该提案的创新在于开发儿茶酚官能化聚合物，以改善医疗器械涂层的润滑性。公共健康相关性：该提案将为心血管医疗设备开发涂层，以增加光滑性和与血液的相容性。它针对的是设备制造中使用的特定材料，这些材料很难用受贻贝启发的新颖方法进行涂层。这些受贻贝启发的涂层应该可以更轻松地插入医疗设备，同时减少组织损伤和疼痛。改进的医疗设备将提高患者的舒适度和健康。