Zwitterionic Graft Coatings for Enhanced Orthopedics

用于增强骨科的两性离子移植涂层

基本信息

  • 批准号:
    8001266
  • 负责人:
  • 金额:
    $ 15万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-09-07 至 2012-03-06
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Project Summary This Phase I SBIR project is designed to develop new zwitterionic graft methodology for orthopedic surfaces with enhanced durability. As Americans live longer and more active lives, total joint replacement is becoming more common. Current orthopedic joints have average lifespans of approximately 20 years. By that point wear on the joint causes particulate formation, with subsequent pain and inflammation, requiring eventual revision. Revision surgeries to replace joint implants are more difficult, painful, and expensive than initial joint replacement. The work proposed extends academic research on photochemically grafting biomimetic phosphoryl choline (PC) monomers to ultrahigh molecular weight polyethylene (UHWMPE). Grafting PC monomers creates 100-200 nm polymer coatings which reduce wear significantly while also decreasing pro-inflammatory cytokine release and macrophage recruitment in vivo. However, grafting process times are unwieldy for high volume manufacturing. This proposal focuses on using our proprietary photocrosslinker TriLite(R) to form an intermediate layer which bonds to the polyethylene surface, crosslinks the surface, and initiates graft polymerization. The TriLite(R) layer will not desorb from the surface under the graft conditions, leading to a more uniform and faster graft. The novelty of the proposal is the use of a new photocrosslinker to speed graft time, increase crosslinking, and improve uniformity, as well as use of several different zwitterionic monomers and copolymer coating methodologies. The resulting coating will be optimized for lubricity, uniformity, thickness and wear durability. The graft processes developed in this work will foster longer lasting, more biocompatible implant materials for many Americans. PUBLIC HEALTH RELEVANCE: Project Narrative Approximately 600,000 Americans receive knee and hip implants annually in the US, over 1 million worldwide. These implants have a lifetime of approximately 20 years, less for more active recipients. This proposal is designed to increase the product lifetime of orthopedic implants. This market is already large, over $5.4 billion in 2006, and more than a fivefold increase in the number of total joint replacements is expected in the next 20 years. Improved orthopedic materials with better wear characteristics would not only contribute to the US economy, but also improve the lives of many Americans by eliminating the need for painful revision surgeries in their later years.
项目概述:第一阶段SBIR项目旨在开发新的两性离子接枝方法,用于增强骨科表面的耐用性。随着美国人寿命的延长和活动量的增加,全关节置换术正变得越来越普遍。目前的骨科关节的平均寿命约为20年。到那时,关节磨损会导致颗粒形成,随之而来的是疼痛和炎症,最终需要翻修。更换关节植入物的翻修手术比初始关节置换术更困难、更痛苦、更昂贵。本研究扩展了光化学接枝仿生磷酰胆碱(PC)单体到超高分子量聚乙烯(UHWMPE)的学术研究。接枝PC单体形成100-200纳米的聚合物涂层,显著减少磨损,同时减少促炎细胞因子的释放和体内巨噬细胞的募集。然而,对于大批量生产来说,嫁接过程的时间是难以处理的。该提案的重点是使用我们专有的光交联剂TriLite(R)来形成一个中间层,该中间层与聚乙烯表面结合,交联表面,并引发接枝聚合。在接枝条件下,TriLite(R)层不会从表面解吸,从而使接枝更加均匀和快速。该方案的新颖之处在于使用一种新的光交联剂来加快接枝时间,增加交联,提高均匀性,以及使用几种不同的两性离子单体和共聚物涂层方法。所得到的涂层将在润滑性、均匀性、厚度和耐磨性方面进行优化。在这项工作中开发的移植物过程将为许多美国人培育更持久,更具有生物相容性的植入材料。

项目成果

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Kristin S Taton其他文献

Kristin S Taton的其他文献

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{{ truncateString('Kristin S Taton', 18)}}的其他基金

Ureteral Stent Coatings
输尿管支架涂层
  • 批准号:
    8454859
  • 财政年份:
    2013
  • 资助金额:
    $ 15万
  • 项目类别:
Catechol-functionalized Coatings for Medical Devices
用于医疗器械的儿茶酚官能化涂料
  • 批准号:
    8252882
  • 财政年份:
    2009
  • 资助金额:
    $ 15万
  • 项目类别:
Catechol-functionalized Coatings for Medical Devices
用于医疗器械的儿茶酚官能化涂料
  • 批准号:
    8438386
  • 财政年份:
    2009
  • 资助金额:
    $ 15万
  • 项目类别:
Catechol-functionalized Coatings for Cardiovascular Medical Devices
用于心血管医疗器械的儿茶酚功能化涂层
  • 批准号:
    7671113
  • 财政年份:
    2009
  • 资助金额:
    $ 15万
  • 项目类别:
Multianalyte Nanomagnetic Biosensor Array for Pathogen Detection
用于病原体检测的多分析物纳米磁性生物传感器阵列
  • 批准号:
    7109789
  • 财政年份:
    2006
  • 资助金额:
    $ 15万
  • 项目类别:
Microsphere Coatings for Immunoassays
用于免疫分析的微球涂层
  • 批准号:
    6994579
  • 财政年份:
    2005
  • 资助金额:
    $ 15万
  • 项目类别:

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