Diet and Breast Density over Time in US Chinese Women

移民到美国后，中国女性经历了一个转变，患乳腺癌的风险增加。 了解在外国出生的华裔美国人随着时间的推移生活方式的变化 女性，如饮食的变化，可以有助于我们理解如何适应文化， 变化，特别是在成年期，影响乳腺癌的风险。乳腺密度代表 特别有用的风险标志物，因为它与乳腺癌密切相关， 乳房密度随时间的变化可能反映了近期行为和暴露的影响。的 拟议研究的目的是首次描述饮食和乳房的变化， 第一代华裔美国妇女的密度随时间的变化，并检查饮食和其他 乳腺密度变化的相关性。我们将招募420名绝经前或围绝经期的中国人 在美国居住<7年的筛查乳腺X线摄影年龄的美国女性。数据收集将 包括关于饮食摄入、文化适应以及健康和生殖健康基线调查表 病史; 4天饮食回忆;人体测量;血清胰岛素样生长因子-L水平; 以及乳房密度筛查。两个后续措施相同 将每隔12至24个月获得一次因子。饮食、其他行为因素的变化， 将描述乳房密度，以及饮食和乳房密度变化的其他相关因素。 研究小组和费城一个相当大的华裔社区的存在 该地区提供了第一次机会，检查饮食和乳房密度随时间的变化，在一个独特的 第一代华裔美国女性的样本。调查结果将在多大程度上解决 与文化适应相关的生活方式改变有助于经历乳腺癌风险的转变 美国华裔女性。他们还将讨论乳腺癌风险的可修改性问题 通过检查成年期风险因素的变化， 确定最重要的具体因素。

Upon migration to the US, Chinese women undergo a transition to increased risk for breast cancer. An understanding of lifestyle changes that occur over time in foreign-born Chinese American women, such as changes in diet, could contribute to our understanding of how acculturative changes, particularly in adulthood, affect breast cancer risk. Breast density represents an especially useful marker of risk because of its strong association with breast cancer, and because change in breast density over time may reflect the effects of recent behaviors and exposures. The objectives of the proposed study are to characterize for the first time changes in diet and breast density over time in first-generation Chinese American women, and to examine dietary and other correlates of change in breast density. We will recruit 420 pre- or peri-menopausal Chinese American women of screening mammography age with US residence <7 years. Data collection will include baseline questionnaires on dietary intake, acculturation, and health and reproductive histories; 4-day dietary recalls; anthropometric measures; serum insulin-like growth factor-l level; and a screening mammogram assessed for breast density. Two follow-up measures of the same factors will be obtained at 12- to 24-month intervals. Changes in diet, other behavioral factors, and breast density will be described, as well as dietary and other correlates of breast density change. The research team and the presence of a sizable Chinese American community in the Philadelphia area offer a first opportunity to examine changes in diet and breast density over time in a unique sample of first-generation Chinese American women. Findings will address the extent to which acculturation-related lifestyle changes contribute to the transition in breast cancer risk experienced by Chinese American women. They will also address the issue of modifiability of breast cancer risk in women regardless of ethnicity by examining changes in risk factors during adulthood and by identifying the specific factors of greatest importance.