COBRE: UAF: BIOLOGICAL SPECIMENS AND GENETICS CORE C

COBRE：UAF：生物样本和遗传学核心 C

• 批准号: 8360228
• 负责人: SCARLETT H HOPKINS
• 金额: $ 6.17万
• 依托单位: UNIVERSITY OF ALASKA FAIRBANKS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360228
• 关键词: Alaska Native; Biological; Centers of Research Excellence; Chronic Disease; Communities; Databases; Disease; Ensure; Epidemiologist; Eskimo Population; Ethics; Etiology; Funding; Genetic; Genotype; Grant; Health Priorities; Heredity; Investigation; Laboratories; Methods; National Center for Research Resources; Obesity; Phase; Principal Investigator; Privacy; Process; Psychologist; Research; Research Infrastructure; Research Personnel; Resources; Risk Factors; Role; Rural; Sampling; Secure; Services; Shipping; Ships; Source; Specimen; Students; Tribal Elders; United States National Institutes of Health; Yup' ik; base; cost; design; experience; member

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Biological Specimens and Genetics (BSG) Core provides key services necessary to facilitate collaborative investigations between geneticists, statisticians, epidemiologists, psychologists, and community leaders that are aimed at understanding the interaction of obesity-related risk factors in Yup'ik Eskimos. Additionally, the BSG core provides valuable community, and state-wide services related to the ethical conduct of culturally respectful genetic studies in rural Alaska Native communities. The BSG Core accomplishes these objectives by advising new investigators on the role of heredity in disease etiology, and on the ascertainment of familial relationships using methods that maximize the privacy of participating and non-participating community members. The BSG Core ensures that biological samples are processed to retain sample integrity and stored in a secure facility, and maintains a specimen database to manage and track samples shipped to collaborating laboratories. In addition, the BSG Core provides genotyping expertise to new investigators and students. The design of the BSG Core is based on our experiences and use of the Genetics Core in phase I of the CANHR study, and on the stated health priorities of our community partners and Tribal Elders.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 生物标本和遗传学（BSG）核心提供必要的关键服务，以促进遗传学家，统计学家，流行病学家，心理学家和社区领导人之间的合作调查，旨在了解Yup'ik爱斯基摩人肥胖相关风险因素的相互作用。此外，BSG核心提供了宝贵的社区和全州范围的服务，这些服务与阿拉斯加农村原住民社区尊重文化的遗传研究的道德行为有关。BSG核心通过向新的研究人员提供关于遗传在疾病病因学中的作用以及使用最大限度地保护参与和非参与社区成员隐私的方法确定家庭关系的建议来实现这些目标。BSG Core确保生物样本经过处理以保持样本完整性并存储在安全的设施中，并维护样本数据库以管理和跟踪运送到合作实验室的样本。此外，BSG核心为新的研究人员和学生提供基因分型专业知识。 BSG核心的设计是基于我们的经验和CANHR研究第一阶段遗传核心的使用，以及我们社区合作伙伴和部落长老的健康优先事项。