Training in the Neurobiology of Neurological Disease

神经系统疾病的神经生物学培训

• 批准号: 10614538
• 负责人: Peter Strick
• 金额: $ 47.75万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10614538
• 关键词: Neurobiology; Training; nervous system disorder

This proposal requests renewal of postdoctoral training in the Neurobiology of Neurological Disease. This is a 2 year program that currently funds six fellows each year. Due to the success of this program, as well as the large number of qualified candidates and faculty mentors, we seek an increase to cover eight fellows. Our program has five primary goals: 1) To foster understanding of the diseases and syndromes that are of high relevance to NINDS; 2) To ensure that trainees are appropriately mentored in their research and that they acquire the professional skills necessary for independent careers in neuroscience; 3) To afford opportunities for innovative research; 4) To attract underrepresented minorities to postdoctoral training in neuroscience; and 5) To support training of "special cases" – individuals whose needs differ from those of the typical training fellow. These special cases may include individuals with computational backgrounds who now seek biological training, as well as young scientists who take on projects that require extended time and effort for completion. Our program requires trainees to be active participants in a two-year course on the “Neurobiology of Disease.” Many sessions of the course are taught by an academic clinician and a basic scientist, and include patients to illustrate a relevant disease or syndrome that is the topic of the session. The course is spread over two years to cover the full spectrum of diseases and syndromes. This time period also makes it easier to schedule the participation of patients and active clinicians. At least two presentations per year are devoted to critical analysis of clinical research, as well as basic science papers. This allows trainees to discuss issues relevant to experimental design and data analysis. We also provide trainees with a two-step "Professional Development Series" that is tailored to the specific needs of early- and late-phase postdoctoral fellows in neuroscience. The professional development series includes topics ranging from grant writing to exploring job opportunities and setting up a first lab. Trainees can also take additional courses, as needed, to fill in gaps in their background. At the core of every postdoctoral experience is mentored research in an accomplished laboratory. To oversee this experience we have devised a mentoring program that includes regular review of both the trainee and the mentor. Each trainee has a primary research adviser as well as an individualized Research Advisory Committee. This arrangement has proven to be especially helpful to Early Stage Investigators who have trainees in their laboratories for the first time. Our 49 training faculty supervise 55 postdoctoral trainees. More than half of these trainees are eligible for individual NRSA and/or T32 support. We believe that the quality and breadth of our faculty, the state-of-the-art facilities, and the unique nature of our training program enable us to attract outstanding fellows and provide them with a special experience.

该提案要求更新神经疾病神经生物学的博士后培训。 这是一个为期2年的计划，目前每年资助6名研究员。由于该计划的成功， 由于合格的候选人和教员导师人数众多，我们寻求增加人数，以包括8名研究员。 我们的计划有五个主要目标：1）促进对高血压疾病和综合征的理解， 2）确保学员在研究中得到适当的指导， 获得神经科学独立职业所需的专业技能; 3）提供机会 4）吸引代表性不足的少数民族参加神经科学博士后培训; 5)支持“特殊情况”的培训-其需要不同于典型培训的个人 家伙.这些特殊情况可能包括具有计算背景的个人，他们现在寻求生物学上的 培训，以及年轻的科学家谁承担的项目，需要延长时间和精力来完成。 我们的计划要求学员积极参与为期两年的“神经生物学”课程， 疾病”。该课程的许多部分由学术临床医生和基础科学家授课，包括 病人说明相关的疾病或综合征，这是会议的主题。课程分布在 两年内涵盖所有疾病和综合征。这段时间也使得更容易 安排患者和在职临床医生的参与。每年至少有两次专题介绍， 临床研究的批判性分析，以及基础科学论文。这使学员能够讨论问题 与实验设计和数据分析有关。我们还为学员提供两步“专业 发展系列”，这是专为早期和后期博士后研究员的具体需求， 神经科学专业发展系列包括从撰写拨款到探索工作的主题 机会，建立第一个实验室。学员还可以根据需要参加其他课程，以填补 他们的背景。 每一个博士后经验的核心是在一个成熟的实验室指导研究。到 监督这一经验，我们已经制定了一个指导计划，包括定期审查的学员， 还有导师每个学员都有一个主要的研究顾问以及个性化的研究顾问 以马克思这种安排已被证明是特别有帮助的早期阶段的研究人员谁有 第一次在他们的实验室实习。 我们的49个培训教师监督55名博士后学员。这些受训人员中有一半以上符合资格 个人NRSA和/或T32支持。我们相信，我们的教师的质量和广度， 国家的最先进的设施，我们的培训计划的独特性质，使我们能够吸引优秀的研究员 并为他们提供特殊的体验。

项目成果

Alterations in Cerebral Blood Flow after Resuscitation from Cardiac Arrest.

• DOI: 10.3389/fped.2017.00174
• 发表时间: 2017
• 期刊: Frontiers in pediatrics
• 影响因子: 2.6
• 作者: Iordanova B;Li L;Clark RSB;Manole MD
• 通讯作者: Manole MD

Histological evaluation of a chronically-implanted electrocorticographic electrode grid in a non-human primate.

• DOI: 10.1088/1741-2560/13/4/046019
• 发表时间: 2016-08
• 期刊: Journal of neural engineering
• 影响因子: 4
• 作者: Degenhart AD;Eles J;Dum R;Mischel JL;Smalianchuk I;Endler B;Ashmore RC;Tyler-Kabara EC;Hatsopoulos NG;Wang W;Batista AP;Cui XT
• 通讯作者: Cui XT

Elucidating opportunities and pitfalls in the treatment of experimental traumatic brain injury to optimize and facilitate clinical translation.

• DOI: 10.1016/j.neubiorev.2017.05.022
• 发表时间: 2018-03
• 期刊: Neuroscience and biobehavioral reviews
• 影响因子: 8.2
• 作者: de la Tremblaye PB;O'Neil DA;LaPorte MJ;Cheng JP;Beitchman JA;Thomas TC;Bondi CO;Kline AE
• 通讯作者: Kline AE

DNA Damage Increases Secreted Aβ40 and Aβ42 in Neuronal Progenitor Cells: Relevance to Alzheimer's Disease.

• DOI: 10.3233/jad-220030
• 发表时间: 2022
• 期刊: JOURNAL OF ALZHEIMERS DISEASE
• 影响因子: 4
• 作者: Welty, Starr;Thathiah, Amantha;Levine, Arthur Samuel
• 通讯作者: Levine, Arthur Samuel

Circadian rhythms and metabolism: from the brain to the gut and back again.

• DOI: 10.1111/nyas.13188
• 发表时间: 2016-12
• 期刊: Annals of the New York Academy of Sciences
• 影响因子: 5.2
• 作者: Cribbet MR;Logan RW;Edwards MD;Hanlon E;Bien Peek C;Stubblefield JJ;Vasudevan S;Ritchey F;Frank E
• 通讯作者: Frank E