Training in the Neurobiology of Neurological Disease

描述（由申请人提供）：该提案要求资助一个新的博士后培训计划，题为“神经疾病的神经生物学培训”。“简而言之，该计划有5个主要目标：1）促进对与我们学员的研究职业高度相关的疾病和综合征的理解; 2）确保学员在研究中得到适当的指导，并获得神经科学独立职业所需的专业技能; 3）提供创新研究的机会; 4）吸引代表性不足的少数民族参加神经科学博士后培训，5）支持“特殊情况”的培训-其需求不同于典型培训研究员的个人。这些特殊情况可能包括具有计算背景的个人，他们现在正在寻求生物培训，以及年轻的科学家，他们承担的项目需要延长时间和精力才能完成。 我们的建议包括一个为期两年的疾病神经生物学课程。该课程积极涉及学术临床医生和他们的病人，以涵盖与基础和翻译神经科学家相关的疾病和综合征的全方位。我们还为学员提供两步“专业发展系列”，这是专门为神经科学早期和后期博士后研究员的具体需求。专业发展系列包括从赠款写作到探索工作机会和建立第一个实验室的主题。学员将 还应提供机会，根据需要参加额外的课程，以填补其背景的空白。 每一个博士后经验的核心是在一个成熟的实验室指导研究。为了监督这一经验，我们设计了一个指导计划，包括定期审查的学员和导师。每个学员将有一个主要的研究顾问以及个性化的研究咨询委员会。这种安排将特别有助于早期研究者谁将有学员在他们的实验室第一次。 我们丰富的神经科学环境包括44名初级培训科学家和12名专门针对T32的初级学院。目前，这一核心培训教师监督超过 75名博士后实习生（除了大量博士前学生之外）。其中近50名受训人员有资格获得NRSA和/或T32支助。我们的神经科学社区包括匹兹堡大学多个基础科学和临床部门的广泛神经科学家，以及我们姐妹机构部门的基础科学家， 卡内基梅隆大学。因此，我们相信，我们的教师，国家的最先进的设施，我们的培训计划的独特性质的质量和广度将使我们能够吸引优秀的博士后学员，并为他们提供一个特殊的经验。

DESCRIPTION (provided by applicant): This proposal requests funding for a new postdoctoral training program entitled, "Training in the Neurobiology of Neurological Disease." Briefly, the program has 5 primary goals: 1) To foster understanding of the diseases and syndromes that are of high relevance to the research careers of our trainees; 2) To ensure that trainees are appropriately mentored in their research and that they acquire the professional skills necessary for independent careers in neuroscience; 3) To afford opportunities for innovative research; 4) To attract under-represented minorities to postdoctoral training in neuroscience, and 5) To support training of "special cases" - individuals whose needs differ from those of the typical training fellow. These special cases may include individuals with computational backgrounds who now seek biological training, as well as young scientists who take on projects that require extended time and effort for completion. Our proposal includes a two-year course on the Neurobiology of Disease. The course actively involves academic clinicians and their patients to cover the full spectrum of diseases and syndromes that are of relevance to basic and translational neuroscientists. We also provide trainees with a two-step "Professional Development Series" that is tailored to the specific needs of early- and late-phase postdoctoral fellows in neuroscience. The professional development series includes topics ranging from grant writing to exploring job opportunities and setting up a first lab. Trainees will also be provided with the opportunity to take additional courses, as needed, to fill in gaps in ther background. At the core of every postdoctoral experience is mentored research in an accomplished laboratory. To oversee this experience we have devised a mentoring program that includes regular review of both the trainee and the mentor. Each trainee will have a primary research adviser as well as an individualized Research Advisory Committee. This arrangement will be especially helpful to Early Stage Investigators who will have trainees in their laboratorie for the first time. Our rich neuroscience environment includes 44 primary training scientists and 12 junior faculties specific to this T32. Currently this core training faculty supervises more than 75 postdoctoral trainees (in addition to a substantial number of pre-doctoral students). Nearly 50 of these trainees are eligible for NRSA and/or T32 support. Our neuroscience community includes a broad range of neuroscientists in multiple basic science and clinical departments at the University of Pittsburgh, as well as basic scientists in departments at our sister institution, Carnegie Mellon University. Thus, we believe that the quality and breadth of our faculty, the state-of-the-art facilities, and the unique nature of our training program will enable us to attrac outstanding postdoctoral trainees and provide them with a special experience.