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The Neural Basis of the Brain-Body Connection

脑与身体连接的神经基础

基本信息

批准号：
10471447
负责人：
Peter Strick
金额：
$ 116.88万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-10 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10471447
关键词：
Adrenal Glands Affect Affective Anxiety Area Awareness Back Basic Science Blood Pressure Brain Brain Stem Cardiovascular system Cerebral cortex Cognition Cognitive Complex Data Development Digestion Disease Endocrine Exercise Fibromyalgia Foundations Functional disorder General Population Generations Goals Heart Heart Diseases Housing Human Human Resources Hypothalamic structure Immune system Immunity Immunohistochemistry Infrastructure Institutes Interneurons Irritable Bowel Syndrome Kidney Knowledge Label Laboratories Link Medical Meditation Mental Depression Methods Mind Modern Medicine Monkeys Motor Nature Neuraxis Neuroanatomy Neurons Neurosciences Research Operative Surgical Procedures Organ Output Pathology Pathway interactions Play Presynaptic Terminals Process Psychophysiologic Disorders Rabies virus Reptiles Research Research Personnel Role Signal Transduction Site Source Spleen Stomach Stress Symptoms Synapses System Techniques Testing Time Tracer Training United States National Institutes of Health Vaccinated Virus Work base body system connectome emotional factor experience experimental study gastrointestinal function gastrointestinal system innovation interest neural circuit neural network neuronal cell body neurotropic virus nonhuman primate novel strategies programs relating to nervous system restraint

项目摘要

We know almost nothing about the neural basis of the Brain-Body connection. This connection is the circuitry that enables motor, cognitive and affective processing to have a major impact on the function of internal organs such as the stomach, heart and spleen. Inappropriate signals in these networks are thought to contribute to the generation of some prevalent medical illnesses, and to cause the so-called "functional" and psychosomatic disorders. The experiments proposed in this application will fill a major gap in our knowledge. We will identify the cortical areas that influence, and in some instances control the function of the gastrointestinal (GI), cardiovascular and immune systems. The brain-body connection is based on chains of synaptically-connected neurons. No conventional neuroanatomical tracer is capable of revealing multi-synaptic circuits. To overcome this shortcoming, we developed the use of rabies virus as a transneuronal tracer in non-human primates. We propose to use this unique approach to reveal the complex networks that are responsible for the top-down influence of the central nervous system on the stomach, heart and spleen. There is a growing awareness that many medical symptoms, especially those without identifiable pathology, may be caused by a disturbance in the brain-body connection. This is especially the case for often intractable disorders such as irritable bowel syndrome, stress- and depression-related heart disease, and fibromyalgia. Thus, the information that will come from our studies has the potential to transform the way we view and treat these disorders. In essence, the brain-body connection is a construct that lacks a concrete basic science foundation. The results from the proposed research will establish a structural framework for the brain-body connection and thus, create new opportunities for rigorous research and novel approaches for treatment. This information, because of its all-encompassing nature, will be of interest to many, if not all of the NIH Institutes and Centers.

我们对脑-体联系的神经基础几乎一无所知。这种联系就是