Observing auditory mechanics with pressure and motion measurements

通过压力和运动测量来观察听觉力学

• 批准号: 8227963
• 负责人: ELIZABETH S. OLSON
• 金额: $ 34.21万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-03-01 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8227963
• 关键词: Abbreviations; Acoustic Nerve; Acoustics; Action Potentials; Air; Anatomy; Auditory; Basilar Membrane; Brain; Caliber; Clinical; Cochlea; Cochlear Implants; Cochlear duct; Cochlear implant procedure; Complement; Complex; Coupled; Crystalline Lens; Development; Ear; External auditory canal; Eye; Frequencies; Gerbils; Glass; Hearing; Histology; Hybrids; Image; Implant; Individual; Injection of therapeutic agent; Knowledge; Laboratories; Labyrinth; Laser-Doppler Velocimetry; Lasers; Lead; Liquid substance; Location; Masks; Measurement; Measures; Mechanics; Methodology; Methods; Monitor; Motion; Nature; Organ of Corti; Pattern; Plant Roots; Population; Process; Rodent; Scala Tympani; Sensory; Series; Side; Signal Transduction; Sorting - Cell Movement; Speed; Staging; Stapes; Surface; Techniques; Testing; Tissues; Tympanic membrane; Variant; Work; auditory stimulus; base; design; discount; expectation; extracellular; implantation; in vivo; interest; middle ear; miniaturize; novel; operation; platinum electrode; pressure; public health relevance; remediation; research study; response; round window; sensor; sound; tectorial membrane; theories; transmission process; vibration; voltage

DESCRIPTION (provided by applicant): Exploring Auditory Mechanics with Pressure and Motion Measurements. The series of experiments proposed here use pressure sensors and other special techniques developed in our lab, complemented by well-established methods like laser-doppler velocimetry, to explore auditory mechanics. The projects of the first four aims continue and extend our previous work on inner and middle ear mechanics. The final aim develops and evaluates a new method for deep cochlear implant insertion. Sound input causes a wave-pattern of sensory tissue motion within the inner ear that is conveyed to the auditory nerve, leading to hearing. This takes place within cochlear compartments having very limited experimental accessibility. Aims one and two of the studies proposed here will push into these barely accessible compartments with specialized micro-sensors. Aim one uses a further miniaturized micro-pressure sensor for in vivo measurements of scala media pressure. Aim two advances our lab's well- established scala tympani pressure measurements by combining them with cochlear microphonic measurements at the same location, within micrometers of the organ of Corti. Both aims are designed to test specific theoretical predictions in order to have a strong impact on the advancement of knowledge. Sound is transmitted by the middle ear with high fidelity even at frequencies where the eardrum has a complex, random-wavy response to sound. Recent theories employ the eardrum wave for sound transmission, and our aim three tests that prediction by changing the wave speed with stiffening agents, measuring the wave speed with a laser velocimeter and also monitoring sound transmission with intracochlear pressure. Our second middle ear aim explores a theoretical prediction that the air cavity behind the eardrum provides reflection that is the basis for good sound transmission at high frequencies. Finally, our last aim explores a novel method for deep cochlear implant insertion using viscous forces. The method will by evaluated physiologically in the proposed studies. PUBLIC HEALTH RELEVANCE: Exploring auditory mechanics with pressure and motion measurements. The core objective of the project is to understand the mechanical processing of the auditory periphery: how the middle ear effectively transmits sound to the inner ear, and the mechanical processing that leads to a frequency-sorted pattern of vibration along the long narrow strip of sensory tissue in the inner ear. Additionally, we have developed a non-traumatic method of cochlear implant insertion and will further develop and test this method. We use micro-pressure-sensors that were developed in our laboratory, and laser-based methods for measuring tiny motions, in order to test current theories of the operation of the ear and measure mechanical responses in implanted inner ears.

描述(申请人提供)：通过压力和运动测量探索听觉力学。这里提出的一系列实验使用了我们实验室开发的压力传感器和其他特殊技术，并辅之以激光多普勒测速等成熟的方法来探索听觉力学。前四个目标的项目继续和扩展了我们以前在内耳和中耳力学方面的工作。最终目的是开发和评价一种新的人工耳蜗术式。声音输入导致内耳内感觉组织运动的波型，该波型被传递到听神经，从而导致听力。这发生在实验可及性非常有限的耳蜗室内。AIMS这里提出的一项和两项研究将推进这些几乎无法进入的带有专门微型传感器的隔间。目的一种进一步小型化的微压传感器用于在体测量Scala中压。目的将我们实验室成熟的鼓阶压力测量与耳蜗微音管测量结合起来，使其在同一位置，在Corti器官的微米范围内进行改进。这两个目的都是为了检验具体的理论预测，以便对知识的进步产生强大的影响。即使在鼓膜对声音有复杂的随机波动反应的频率上，中耳也能以高保真的方式传输声音。最近的理论是利用鼓膜波来传播声音，我们的目的是通过用硬化剂改变波速、用激光测速仪测量波速和用耳腔内压监测声音传播来预测。我们的第二个中耳目标探索了一个理论预测，即鼓膜后面的空气腔提供反射，这是高频下良好声音传输的基础。最后，我们的最终目标是探索一种利用粘性力进行深部人工耳蜗植入的新方法。该方法将在拟议的研究中进行生理学评估。 公共卫生相关性：通过测量压力和运动来探索听觉机制。该项目的核心目标是了解听觉外周的机械处理：中耳如何有效地将声音传递到内耳，以及导致沿着内耳感觉组织的长而窄的条状振动的机械处理。此外，我们还开发了一种非创伤性的人工耳蜗植入方法，并将进一步开发和测试这种方法。我们使用我们实验室开发的微型压力传感器和基于激光的方法来测量微小运动，以测试当前耳朵操作的理论，并测量植入的内耳的机械响应。