Auditory Mechanics and the Cochlear Amplifier 2020

听觉力学和耳蜗放大器 2020

基本信息

  • 批准号:
    10569100
  • 负责人:
  • 金额:
    $ 51.65万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-03-01 至 2026-02-28
  • 项目状态:
    未结题

项目摘要

Project Summary / Abstract: Auditory Mechanics and Cochlear Amplification 2020 Sound input to the cochlea causes a frequency-sorted wave-pattern of sensory tissue motion that conveys sound information to the auditory neurons, leading to hearing. A currently untreatable aspect of hearing impairment is the deterioration of the cochlea's ability to sharply separate sound by frequency. The cochlea's healthy frequency tuning is largely provided by the cochlear amplifier, an outer-hair-cell-driven, place-frequency-localized electromechanical feedback mechanism that is both powerful and fragile. This project's aims 1-3 explore the cell/structure basis of cochlear amplification. The studies use intracochlear sensors and a cutting-edge imaging and vibrometry technology, spectral-domain optical-coherence-tomography (SD-OCT). Localized measurements of mechanical and electrical responses at and within the cochlea's sensory tissue will be made both in healthy normal and in modified cochleae. Gerbils and guinea pigs are used and critical aspects of cochlear amplification are compared in the two species in aim 2. In aim 1, measurements are made in cochleae before and after intracochlear injection of substances that will modify tectorial membrane (TM) mechanics. Because it governs transduction in hair cells, the TM plays a profound role in cochlear amplification; our studies test hypotheses that are based on cochlear models and measurements in isolated TMs and in TM-mutant mice. Aim 3 makes use of SD-OCT's penetrating abilities to test previously untestable fluid-mechanical properties of the organ of Corti. Aim 4 explores the transmission of sound to the cochlea by the middle ear, and how this transmission is modified by feedback from the middle ear muscle, tensor tympani. In preliminary work, tensor tympani modified transmission in a subtle, frequency-dependent manner that could be involved in focusing on particular sound sources, for example during communication. Experiments in which tensor tympani is tensed with voltage pulses will determine how the muscle affects the transmitted sound signal.
项目概述/摘要:听觉力学与耳蜗放大,2020

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

ELIZABETH S. OLSON其他文献

ELIZABETH S. OLSON的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('ELIZABETH S. OLSON', 18)}}的其他基金

Auditory Mechanics and the Cochlear Amplifier 2020
听觉力学和耳蜗放大器 2020
  • 批准号:
    10330593
  • 财政年份:
    2016
  • 资助金额:
    $ 51.65万
  • 项目类别:
Intracochlear measures of active cochlear mechanics
主动耳蜗力学的耳蜗内测量
  • 批准号:
    7993087
  • 财政年份:
    2009
  • 资助金额:
    $ 51.65万
  • 项目类别:
Intracochlear measures of active cochlear mechanics
主动耳蜗力学的耳蜗内测量
  • 批准号:
    7770498
  • 财政年份:
    2009
  • 资助金额:
    $ 51.65万
  • 项目类别:
EXPOSING MECHANICAL IMPEDANCE OF THE COCHLEAR PARTITION
暴露耳蜗分区的机械阻抗
  • 批准号:
    2592077
  • 财政年份:
    1997
  • 资助金额:
    $ 51.65万
  • 项目类别:
OBSERVING AUDITORY MECHANICS WITH PRESSURE MEASUREMENTS
通过压力测量观察听觉力学
  • 批准号:
    6547427
  • 财政年份:
    1996
  • 资助金额:
    $ 51.65万
  • 项目类别:
Observing auditory mechanics with pressure and motion measurements
通过压力和运动测量来观察听觉力学
  • 批准号:
    8227963
  • 财政年份:
    1996
  • 资助金额:
    $ 51.65万
  • 项目类别:
Observing auditory mechanics with pressure and motion measurements
通过压力和运动测量来观察听觉力学
  • 批准号:
    8105869
  • 财政年份:
    1996
  • 资助金额:
    $ 51.65万
  • 项目类别:
Observing auditory mechanics with pressure and motion measurements
通过压力和运动测量来观察听觉力学
  • 批准号:
    7173390
  • 财政年份:
    1996
  • 资助金额:
    $ 51.65万
  • 项目类别:
Observing auditory mechanics with pressure and motion measurements
通过压力和运动测量来观察听觉力学
  • 批准号:
    8613484
  • 财政年份:
    1996
  • 资助金额:
    $ 51.65万
  • 项目类别:
EXPOSING MECHANICAL IMPEDANCE OF THE COCHLEAR PARTITION
暴露耳蜗分区的机械阻抗
  • 批准号:
    2377588
  • 财政年份:
    1996
  • 资助金额:
    $ 51.65万
  • 项目类别:

相似海外基金

Kilohertz volumetric imaging of neuronal action potentials in awake behaving mice
清醒行为小鼠神经元动作电位的千赫兹体积成像
  • 批准号:
    10515267
  • 财政年份:
    2022
  • 资助金额:
    $ 51.65万
  • 项目类别:
Signal processing in horizontal cells of the mammalian retina – coding of visual information by calcium and sodium action potentials
哺乳动物视网膜水平细胞的信号处理 â 通过钙和钠动作电位编码视觉信息
  • 批准号:
    422915148
  • 财政年份:
    2019
  • 资助金额:
    $ 51.65万
  • 项目类别:
    Research Grants
CAREER: Resolving action potentials and high-density neural signals from the surface of the brain
职业:解析来自大脑表面的动作电位和高密度神经信号
  • 批准号:
    1752274
  • 财政年份:
    2018
  • 资助金额:
    $ 51.65万
  • 项目类别:
    Continuing Grant
Development of Nanosheet-Based Wireless Probes for Multi-Simultaneous Monitoring of Action Potentials and Neurotransmitters
开发基于纳米片的无线探针,用于同时监测动作电位和神经递质
  • 批准号:
    18H03539
  • 财政年份:
    2018
  • 资助金额:
    $ 51.65万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Population Imaging of Action Potentials by Novel Two-Photon Microscopes and Genetically Encoded Voltage Indicators
通过新型双光子显微镜和基因编码电压指示器对动作电位进行群体成像
  • 批准号:
    9588470
  • 财政年份:
    2018
  • 资助金额:
    $ 51.65万
  • 项目类别:
Enhanced quantitative imaging of compound action potentials in multi-fascicular peripheral nerve with fast neural Electrical Impedance Tomography enabled by 3D multi-plane softening bioelectronics
通过 3D 多平面软化生物电子学实现快速神经电阻抗断层扫描,增强多束周围神经复合动作电位的定量成像
  • 批准号:
    10009724
  • 财政年份:
    2018
  • 资助金额:
    $ 51.65万
  • 项目类别:
Enhanced quantitative imaging of compound action potentials in multi-fascicular peripheral nerve with fast neural Electrical Impedance Tomography enabled by 3D multi-plane softening bioelectronics
通过 3D 多平面软化生物电子学实现快速神经电阻抗断层扫描,增强多束周围神经复合动作电位的定量成像
  • 批准号:
    10467225
  • 财政年份:
    2018
  • 资助金额:
    $ 51.65万
  • 项目类别:
Fast high-resolution deep photoacoustic tomography of action potentials in brains
大脑动作电位的快速高分辨率深度光声断层扫描
  • 批准号:
    9423398
  • 财政年份:
    2017
  • 资助金额:
    $ 51.65万
  • 项目类别:
NeuroGrid: a scalable system for large-scale recording of action potentials from the brain surface
NeuroGrid:用于大规模记录大脑表面动作电位的可扩展系统
  • 批准号:
    9357409
  • 财政年份:
    2016
  • 资助金额:
    $ 51.65万
  • 项目类别:
Noval regulatory mechanisms of axonal action potentials
轴突动作电位的新调节机制
  • 批准号:
    16K07006
  • 财政年份:
    2016
  • 资助金额:
    $ 51.65万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了