Mouse Models of Novel Sphingolipid Biology and Disease Mechanisms

新型鞘脂生物学和疾病机制的小鼠模型

• 批准号: 8553553
• 负责人: Richard Proia
• 金额: $ 66.87万
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8553553
• 关键词: Adult; Animal Model; Biological; Biological Process; Biology; Development; Disease; Enzymes; Goals; Homeostasis; Investigation; Lipids; Malignant Neoplasms; Metabolic; Metabolic Diseases; Metabolic Pathway; Metabolism; Mus; Pathway interactions; Physiological; Physiological Processes; Signal Transduction; Signaling Molecule; Sphingolipids; human disease; mouse model; novel; receptor

The sphingolipid metabolic pathway yields highly active lipid signaling molecules that regulate many physiologic processes during development and for homeostasis in the adult. Furthermore, the pathway is highly regulated and appears to function abnormally in certain disordered states such as in cancer and in metabolic diseases. We are utilizing genetically altered mice that are modified in their sphingolipid metabolism and signaling to uncover new functions of sphingolipids in normal biology and in disease.

鞘脂代谢途径产生高度活跃的脂质信号分子，调节发育过程中的许多生理过程和成人体内平衡。此外，该通路受到高度调控，在某些紊乱状态（如癌症和代谢性疾病）中似乎功能异常。我们正在利用改变神经鞘脂代谢和信号的转基因小鼠来发现神经鞘脂在正常生物学和疾病中的新功能。