Sphingolipid Biology and Regulation of Metabolism

鞘脂生物学和代谢调节

• 批准号: 8349854
• 负责人: Richard Proia
• 金额: $ 48.58万
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8349854
• 关键词: Biology; Cells; Diabetes Mellitus; Fatty Acids; Goals; Inflammatory; Link; Lipids; Metabolic Pathway; Metabolism; Mus; Obesity; Palmitoyl Coenzyme A; Pathway interactions; Phospholipid Metabolism; Phospholipids; Process; Regulation; Role; Signal Pathway; Sphingolipids; Sterols; enzyme activity

The sphingolipid metabolic pathway is initiated by the incorporation of palmitoyl CoA, derivative of fatty acids, and ultimately provides substrates for phospholipid metabolism. Thus the sphingolipid metabolic pathway is highly integrated with other dietary and structural lipid metabolic pathways. Furthermore, the sphingolipid metabolites themselves are bioactive and alter cell metabolism via signaling pathways. We have developed, and continue to develop genetically altered mice with modified expression of key sphingolipid enzyme activities in order to study the role of the pathway in metabolism including their role in diabetes and obesity.

鞘脂代谢途径由棕榈酰辅酶A（脂肪酸衍生物）的掺入启动，并最终为磷脂代谢提供底物。 因此，鞘脂代谢途径与其他膳食和结构脂质代谢途径高度整合。此外，鞘脂代谢物本身具有生物活性，并通过信号传导途径改变细胞代谢。我们已经开发并继续开发具有关键鞘脂酶活性的修饰表达的遗传改变小鼠，以研究该途径在代谢中的作用，包括其在糖尿病和肥胖症中的作用。