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Sphingolipid Biology of Neurodegeneration

Sphingolipid Biology of Neurodegeneration
神经变性的鞘脂生物学
批准号：
8349852
负责人：
Richard Proia
金额：
$48.58万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8349852
关键词：
AddressBiologyCatabolismCell membraneClinicalComplexDefectDiseaseFamilyFutureGenesGliosisGoalsInflammationInheritedLongevityMembraneMembrane LipidsModelingMusNerve DegenerationNervous system structureNeurodegenerative DisordersProcessProductionRoleSandhoff DiseaseSignal TransductionSphingolipidsSphingosine-1-Phosphate Receptorimprovedmouse modelneuron apoptosisresearch studysphingosine 1-phosphatesphingosine kinase

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中文摘要
翻译
我们已经确定鞘氨醇激酶/S1P受体轴在神经退行性变过程中起着重要作用。我们使用了一种成熟的桑德霍夫小鼠神经变性模型，包括神经元凋亡、炎症和胶质细胞增生。为了确定S1P的产生是否在神经退行性变过程中起重要作用，我们在Sandhoff模型中删除了Sphk1基因。我们发现，与携带正常Sphk1基因的桑德霍夫小鼠相比，这些小鼠的寿命和临床状况都有显著改善。这些结果表明，Sphk1的表达可能参与了神经退行性变的过程。未来的实验将解决改善病程的机制。
英文摘要
We have determined that the sphingosine kinase/S1P receptor axis has a significant role during neurodegeneration. We used a well-established Sandhoff mouse model of neurodegeneration, which included neuronal apoptosis, inflammation and gliosis. In order to determine if S1P production was important during the neurodegenerative process we deleted the Sphk1 gene in the Sandhoff model. We found a significant improvement in life span and clinical condition of these mice compared with the control Sandhoff mice with a normal Sphk1 gene. These results indicate that Sphk1 expression may have contributed to the neurodegenerative course. Future experiments will address the mechanism of the improved course of the disease.
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会议论文
Mouse Models of Novel Sphingolipid Biology and Disease Mechanisms
Sphingolipid Biology of Inflammation and Immunity
Mouse Models of Novel Sphingolipid Biology and Disease Mechanisms
Sphingolipid Biology and Regulation of Metabolism
国内基金
海外基金
Journal of Integrative Plant Biology
  • 批准号：
    31024801
  • 项目类别：
    专项基金项目
  • 资助金额：
    24.0万元
  • 批准年份：
    2010
  • 负责人：
    贺萍
  • 依托单位：
    中国科学院植物研究所