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Sphingolipid Biology and Regulation of Metabolism

Sphingolipid Biology and Regulation of Metabolism
鞘脂生物学和代谢调节
批准号：
10255243
负责人：
Richard Proia
金额：
$80.57万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10255243
关键词：
BiologyCellular Metabolic ProcessDiabetes MellitusDietary FatsFatty AcidsGoalsImmuneLinkLipidsMetabolic PathwayMetabolismMusObesityPalmitoyl Coenzyme APathway interactionsPhospholipidsProcessRegulationRoleSignal PathwaySphingolipidsSterolsenzyme activitystructured lipid

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相关文献

中文摘要
翻译
鞘磷脂的代谢途径是由脂肪酸的衍生物棕榈酰辅酶A参与启动的，最终为其他脂类的合成提供底物。因此，鞘脂代谢途径与其他膳食和结构脂代谢途径高度整合。此外，鞘磷脂代谢物本身具有生物活性，并通过信号通路改变细胞代谢。我们已经开发并继续开发具有关键鞘磷脂酶活性修饰表达的转基因小鼠，以研究该途径在代谢中的作用，包括它们在糖尿病和肥胖症中的作用。
英文摘要
The sphingolipid metabolic pathway is initiated by the incorporation of palmitoyl CoA, derivative of fatty acids, and ultimately provides substrates for the synthesis of other lipids. Thus the sphingolipid metabolic pathway is highly integrated with other dietary and structural lipid metabolic pathways. Furthermore, the sphingolipid metabolites themselves are bioactive and alter cell metabolism via signaling pathways. We have developed, and continue to develop genetically altered mice with modified expression of key sphingolipid enzyme activities in order to study the role of the pathway in metabolism including their role in diabetes and obesity.
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