Sphingolipid Biology of Inflammation and Immunity

炎症和免疫的鞘脂生物学

• 批准号: 8741513
• 负责人: Richard Proia
• 金额: $ 59.98万
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8741513
• 关键词: Biology; Cells; Disease; Endothelial Cells; Endothelium; Goals; Homeostasis; Immune; Immune response; Immune system; Immunity; Individual; Inflammation; Insulin-Dependent Diabetes Mellitus; Lipids; Lymphatic System; Metabolic Pathway; Obesity; Regulation; Role; Signal Transduction; Sphingolipids; Sphingosine-1-Phosphate Receptor; Systems Development; Vascular System; immune function; receptor; sphingosine 1-phosphate

We are studying the mechanism by which sphingolipids regulate immunity and inflammation. Our focus has been on sphingosine-1-phosphate (S1P), a bioactive lipid enriched in the vascular and lymphatic systems, and the S1P receptors, found on immune cells and the endothelium. Essential roles for S1P and its receptors have been found for immune system development and homeostasis as well as for the regulation of immune responses and inflammation. We are studying the individual roles of the S1P receptors and the sphingolipid metabolic pathway in inflammation and immunity.

我们正在研究鞘脂调节免疫和炎症的机制。我们的重点是鞘氨醇-1-磷酸（S1P），一种富含血管和淋巴系统的生物活性脂质，以及免疫细胞和内皮细胞上发现的S1P受体。已发现S1P及其受体在免疫系统发育和稳态以及免疫反应和炎症的调节中起重要作用。我们正在研究S1P受体和鞘脂代谢途径在炎症和免疫中的个体作用。