Enhanced Surveillance for New Vaccine Preventable Disease

加强对新疫苗可预防疾病的监测

• 批准号: 8478350
• 负责人: Julie Anne Boom
• 金额: $ 40.17万
• 依托单位: TEXAS CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2016-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8478350
• 关键词: Enhanced; Surveillance; New; Vaccine; Preventable

Project Summary: Texas Children's Hospital aims to establish and operate a year round surveillance site as part of a larger national New Vaccine Surveillance Network (NVSN) to better understand the burden of vaccine-preventable disease, the impact of new vaccine and the impact of changing vaccine policies. To understand the disease burden of rotavirus or other vaccine-preventable diseases, the surveillance team at Texas Children's Hospital proposes to enroll children with symptoms of acute gastroenteritis in both emergency and inpatient settings during all grant years. As the Texas Children's Hospital emergency department treats >82,000 children per year from a multi-county area who are demographically similar to the children in the greater Houston area, the hospital is well suited to conduct such surveillance activities. Fecal specimens will be collected from all enrolled children at the time of enrollment or by courier. All fecal specimens will be tested using Rotaclone enzyme immunoassay. Children whose fecal specimens test positive for rotavirus antigen, case patients, will then be compared with healthy patients who present to the Texas Children's Pediatric Associates for well-child care, control patients. Complete vaccination histories will be collected from case and control patients. Vaccine effectiveness for rotavirus, and possibly other vaccine-preventable diseases, will be determined. Additionally, saliva specimens will be collected from a subset of case and healthy children for assessment of FUT2 secretor antigen status. During grant years 2-5, we propose to collaborate with the CDC to assist in the development and implementation of additional projects. These projects may include, but would not be limited to the following: extension of surveillance activities to other vaccine-preventable diseases, evaluation of uptake and impact of new vaccines on provider policies and practice habits, longitudinal studies involving a cohort of children following new vaccine introduction, laboratory studies involving the development of new research methods, and health care costs studies associated with vaccine policy.

项目概要： 德克萨斯儿童医院的目标是建立并运营一个全年监测站点，作为更大的监测站点的一部分 国家新疫苗监测网络（NVSN），以更好地了解疫苗可预防的负担 疾病、新疫苗的影响以及改变疫苗政策的影响。为了了解疾病 德克萨斯儿童医院的监测小组指出，轮状病毒或其他疫苗可预防疾病的负担 建议在急诊和住院环境中招募有急性胃肠炎症状的儿童 在所有资助年期间。德克萨斯儿童医院急诊科每年治疗超过 82,000 名儿童 来自多县地区的儿童在人口统计上与大休斯顿地区的儿童相似， 医院非常适合开展此类监测活动。粪便样本将从所有 儿童在报名时或通过快递报名。所有粪便样本都将使用 Rotaclone 进行测试 酶免疫分析。粪便样本轮状病毒抗原检测呈阳性的儿童、病例患者将 然后与到德克萨斯儿童儿科协会就诊的健康儿童进行比较 护理、控制病人。将从病例和对照患者中收集完整的疫苗接种史。疫苗 将确定对轮状病毒以及可能的其他疫苗可预防疾病的有效性。此外， 将从部分病例和健康儿童中采集唾液样本，用于评估 FUT2 分泌者 抗原状态。在资助的第 2-5 年期间，我们建议与 CDC 合作，协助开发 和实施其他项目。这些项目可能包括但不限于 以下：将监测活动扩展到其他疫苗可预防的疾病、评估吸收情况和 新疫苗对提供者政策和实践习惯的影响，涉及一组的纵向研究 新疫苗引入后的儿童、涉及新研究开发的实验室研究 方法以及与疫苗政策相关的医疗保健成本研究。