Enhanced Surveillance for New Vaccine Preventable Disease

摘要 西雅图儿童医院的调查人员建议建立一个网站来进行基于人群的监测 金郡（人口190万）的儿童寻求紧急护理或需要住院治疗， 疫苗可预防或潜在疫苗可预防的疾病。建立一种新的疫苗 位于西雅图的监视网络（NVSN）站点将在全国范围内提供西海岸代表 监测工作，从该国部分地区采集轮状病毒季节性差异的数据， 轮状病毒疫苗免疫率。由珍妮特·英格伦博士和艾琳·克莱因博士领导的西雅图调查人员， 在监测急性肠胃炎、轮状病毒病和轮状病毒疫苗的有效性方面经验丰富 研究，并有成功进行合作创新的多中心临床研究的历史， 新的和新兴的病原体，疫苗和疫苗可预防的感染在不同的儿科人群。 西雅图儿童医院是该县唯一的儿科医疗中心-急诊科， 包括85%的儿科医院床位，并照顾约50%的急性 在金郡接受住院和门诊治疗的胃肠炎患者。我们全州的免疫登记处， 该计划登记了100%在该州出生的儿童和96%以上的幼儿免疫接种， 协助疫苗有效性研究。与西雅图/国王公共卫生部合作 县（PHSKC），我们建议从我们的医院收集入院数据，并利用现有的全县范围内 监控程序跟踪所有急诊室入院和所有住院治疗， 调整后的人口疾病和住院率。我们的项目目标将是建立一个网站 通过收集流行病学和临床数据、标本和疫苗接种进行基于人群的监测 从症状和对照受试者的验证，并评估轮状病毒疫苗的有效性。我们将 酌情评估其他新疫苗和新疫苗政策的影响，并开展合作 与其他地点和疾病预防控制中心了解疫苗可预防或潜在疫苗的负担- 通过协助制定和实施新项目和新方案，预防可预防的疾病。的 西雅图站点将为NVSN及其在理解和记录 特定病原体和新疫苗的重要性。

ABSTRACT Investigators at Seattle Children's Hospital propose to establish a site to conduct population-based surveillance of children in King County (population 1.9 million) seeking emergency care or requiring hospitalization for vaccine-preventable or potentially vaccine-preventable conditions. The establishment of a New Vaccine Surveillance Network (NVSN) site in Seattle would provide West Coast representation within the national surveillance effort, capturing data from a part of the country with differences in both rotavirus seasonality and immunization rates for rotavirus vaccine. The Seattle investigators, led by Drs. Janet Englund and Eileen Klein, are experienced in surveillance for acute gastroenteritis, rotavirus disease and rotavirus vaccine-effectiveness studies, and have a history of successfully conducting collaborative innovative multicenter clinical studies of new and emerging pathogens, vaccines, and vaccine-preventable infections in diverse pediatric populations. Seattle Children's Hospital, the only pediatric medical center-emergency department in the county, encompasses 85% of pediatric hospital beds and cares for approximately 50% of children with acute gastroenteritis receiving inpatient and outpatient care in King County. Our state-wide immunization registry, which registers 100% of children born in-state and over 96% of immunizations given to young children, will assist in vaccine effectiveness studies. With collaboration from the Public Health Department of Seattle/King County (PHSKC), we propose to collect admission data from our hospital and utilize existing county-wide surveillance programs tracking all emergency room admissions and all hospitalizations to be able to calculate adjusted, populated-based disease and hospitalization rates. Our project objectives will be to establish a site for population-based surveillance by collecting epidemiologic and clinical data, specimens, and vaccination verifications from symptomatic and control subjects, and to evaluate rotavirus vaccine effectiveness. We will assess the impact of other new vaccines and new vaccine policies as appropriate, and work collaboratively with other sites and the CDC to understand the burden of vaccine-preventable or potentially vaccine- preventable diseases by assisting in developing and implementing new projects and new protocols. The Seattle site will contribute substantially to NVSN and their efforts in understanding and documenting the importance of specific pathogens and new vaccines.