Enhanced Surveillance for New Vaccine Preventable Disease

摘要 西雅图儿童医院的研究人员建议建立一个地点来进行基于人口的监测 在国王县(人口190万)寻求紧急护理或需要住院治疗的儿童比例 疫苗可预防的或潜在的疫苗可预防的情况。一种新型疫苗的研制 位于西雅图的监视网络(NVSN)站点将在全国范围内提供西海岸代表 监测工作，从轮状病毒季节性和轮状病毒存在差异的国家部分地区捕获数据 轮状病毒疫苗接种率。由珍妮特·英格伦博士和艾琳·克莱恩博士领导的西雅图调查人员， 在监测急性胃肠炎、轮状病毒病和轮状病毒疫苗方面经验丰富-有效性 研究，并有成功开展协作式创新多中心临床研究的历史 不同儿科人群中新出现的病原体、疫苗和疫苗可预防的感染。 西雅图儿童医院是该县唯一的儿科医疗中心和急诊科， 覆盖了85%的儿科医院床位，并照顾了大约50%的急性肺炎儿童 胃肠炎在金县接受住院和门诊治疗。我们全州的免疫登记处， 它登记了100%在本州出生的儿童和超过96%的幼儿接种疫苗，将 协助疫苗有效性研究。与西雅图/金市公共卫生部合作 县(PHSKC)，我们建议收集我们医院的入院数据，并利用现有的全县 跟踪所有急诊室入院情况和所有住院情况的监控程序能够计算 调整后的以人口为基础的疾病和住院率。我们的项目目标将是建立一个网站 通过收集流行病学和临床数据、样本和接种疫苗进行以人群为基础的监测 来自症状受试者和对照受试者的验证，并评估轮状病毒疫苗的有效性。我们会 评估其他新疫苗和新疫苗政策的影响，并进行协作 与其他网站和疾控中心一起了解疫苗的负担--可预防的或潜在的疫苗-- 通过协助制定和实施新项目和新方案，预防可预防的疾病。这个 西雅图站点将为NVSN及其在理解和记录 特定病原体和新疫苗的重要性。

ABSTRACT Investigators at Seattle Children's Hospital propose to establish a site to conduct population-based surveillance of children in King County (population 1.9 million) seeking emergency care or requiring hospitalization for vaccine-preventable or potentially vaccine-preventable conditions. The establishment of a New Vaccine Surveillance Network (NVSN) site in Seattle would provide West Coast representation within the national surveillance effort, capturing data from a part of the country with differences in both rotavirus seasonality and immunization rates for rotavirus vaccine. The Seattle investigators, led by Drs. Janet Englund and Eileen Klein, are experienced in surveillance for acute gastroenteritis, rotavirus disease and rotavirus vaccine-effectiveness studies, and have a history of successfully conducting collaborative innovative multicenter clinical studies of new and emerging pathogens, vaccines, and vaccine-preventable infections in diverse pediatric populations. Seattle Children's Hospital, the only pediatric medical center-emergency department in the county, encompasses 85% of pediatric hospital beds and cares for approximately 50% of children with acute gastroenteritis receiving inpatient and outpatient care in King County. Our state-wide immunization registry, which registers 100% of children born in-state and over 96% of immunizations given to young children, will assist in vaccine effectiveness studies. With collaboration from the Public Health Department of Seattle/King County (PHSKC), we propose to collect admission data from our hospital and utilize existing county-wide surveillance programs tracking all emergency room admissions and all hospitalizations to be able to calculate adjusted, populated-based disease and hospitalization rates. Our project objectives will be to establish a site for population-based surveillance by collecting epidemiologic and clinical data, specimens, and vaccination verifications from symptomatic and control subjects, and to evaluate rotavirus vaccine effectiveness. We will assess the impact of other new vaccines and new vaccine policies as appropriate, and work collaboratively with other sites and the CDC to understand the burden of vaccine-preventable or potentially vaccine- preventable diseases by assisting in developing and implementing new projects and new protocols. The Seattle site will contribute substantially to NVSN and their efforts in understanding and documenting the importance of specific pathogens and new vaccines.