Enhanced Surveillance for New Vaccine Preventable Disease

描述（由申请人提供）：西雅图儿童医院的研究人员建议建立一个研究中心，对金郡（人口190万）寻求紧急护理或因疫苗可预防或可能疫苗可预防的疾病而需要住院的儿童进行基于人群的监测。在西雅图建立一个新的疫苗监测网络（NVSN）站点将在国家监测工作中提供西海岸的代表性，从该国部分地区获取轮状病毒季节性和轮状病毒疫苗免疫率差异的数据。由Janet Englund和Eileen Klein博士领导的西雅图研究人员在监测急性胃肠炎、轮状病毒疾病和轮状病毒疫苗有效性研究方面经验丰富，并有成功开展新型和新兴病原体、疫苗和疫苗可预防感染的多中心临床研究的历史。西雅图儿童医院是该县唯一的儿科医疗中心-急诊科，拥有85%的儿科医院床位，并照顾金郡约50%接受住院和门诊治疗的急性胃肠炎儿童。我们的全州免疫登记处，登记了100%在本州出生的儿童和96%以上的幼儿免疫接种，将协助疫苗有效性研究。在与西雅图/金郡公共卫生部（PHSKC）的合作下，我们建议从我们医院收集入院数据，并利用现有的全县范围内的监测计划跟踪所有急诊室入院和所有住院情况，以便能够计算调整后的基于人口的疾病和住院率。我们的项目目标是建立一个以人群为基础的监测中心，通过收集流行病学和临床数据，标本，并从症状和对照组的疫苗接种验证，并评估轮状病毒疫苗的有效性。我们将酌情评估其他新疫苗和新疫苗政策的影响，并与其他地点和CDC合作，通过协助开发和实施新项目和新方案，了解疫苗可预防或潜在疫苗可预防疾病的负担。西雅图研究中心将为NVSN及其在理解和记录特定病原体和新疫苗的重要性方面所做的努力做出重大贡献。 公共卫生相关性：西雅图儿童医院的调查人员建议对金郡寻求急诊科护理或需要住院治疗的儿童进行基于人群的监测，这些儿童患有疫苗可预防或潜在疫苗可预防的疾病。我们的医院拥有85%的儿科病床，并照顾约50%的急性胃肠炎儿童，他们在金郡接受住院和门诊治疗，我们能够根据对现有全县艾德和住院监测项目数据的密切跟踪，计算调整后的基于人口的疾病和住院率。西雅图小组在成功启动和完成针对不同儿科人群的新型和新兴病原体以及疫苗可预防感染的创新临床研究方面拥有良好的记录。

DESCRIPTION (provided by applicant): Investigators at Seattle Children's Hospital propose to establish a site to conduct population-based surveillance of children in King County (population 1.9 million) seeking emergency care or requiring hospitalization for vaccine-preventable or potentially vaccine-preventable conditions. The establishment of a New Vaccine Surveillance Network (NVSN) site in Seattle would provide West Coast representation within the national surveillance effort, capturing data from a part of the country with differences in both rotavirus seasonality and immunization rates for rotavirus vaccine. The Seattle investigators, led by Drs. Janet Englund and Eileen Klein, are experienced in surveillance for acute gastroenteritis, rotavirus disease and rotavirus vaccine-effectiveness studies, and have a history of successfully conducting collaborative innovative multicenter clinical studies of new and emerging pathogens, vaccines, and vaccine-preventable infections in diverse pediatric populations. Seattle Children's Hospital, the only pediatric medical center-emergency department in the county, encompasses 85% of pediatric hospital beds and cares for approximately 50% of children with acute gastroenteritis receiving inpatient and outpatient care in King County. Our state-wide immunization registry, which registers 100% of children born in-state and over 96% of immunizations given to young children, will assist in vaccine effectiveness studies. With collaboration from the Public Health Department of Seattle/King County (PHSKC), we propose to collect admission data from our hospital and utilize existing county-wide surveillance programs tracking all emergency room admissions and all hospitalizations to be able to calculate adjusted, populated-based disease and hospitalization rates. Our project objectives will be to establish a site for population-based surveillance by collecting epidemiologic and clinical data, specimens, and vaccination verifications from symptomatic and control subjects, and to evaluate rotavirus vaccine effectiveness. We will assess the impact of other new vaccines and new vaccine policies as appropriate, and work collaboratively with other sites and the CDC to understand the burden of vaccine-preventable or potentially vaccine- preventable diseases by assisting in developing and implementing new projects and new protocols. The Seattle site will contribute substantially to NVSN and their efforts in understanding and documenting the importance of specific pathogens and new vaccines. PUBLIC HEALTH RELEVANCE: Investigators at Seattle Children's Hospital propose to conduct population-based surveillance of children in King County seeking emergency department care or requiring hospitalization for vaccine-preventable or potentially vaccine-preventable conditions. Our hospital encompasses 85% of pediatric hospital beds and cares for approximately 50% of children with acute gastroenteritis receiving inpatient and outpatient care in King County, and we are able to calculate adjusted, populated-based disease and hospitalization rates based on close tracking of data from existing county-wide ED and inpatient surveillance programs. The Seattle group has a proven track record of successfully initiating and completing innovative clinical studies of new and emerging pathogens and vaccine-preventable infections in diverse pediatric populations.