Core C: Research Translation Core

核心 C：研究翻译核心

• 批准号: 8377268
• 负责人: Lindell E Ormsbee
• 金额: $ 24.64万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8377268
• 关键词: Academia; Basic Science; Biochemical; Biomedical Research; Biosensor; Cardiovascular Diseases; Chemical Exposure; Chemicals; Clinical Sciences; Communication; Communication Tools; Communities; Diabetes Mellitus; Diffusion; Disease; Effectiveness; Ensure; Environment; Environmental Health; Environmental Pollution; Exposure to; General Population; Government; Guidelines; Health; Health Professional; Human; Hypertension; Individual; Industry; Investigation; Kentucky; Knowledge; Letters; Malignant Neoplasms; Nanotechnology; Outcome; Outcomes Research; Plants; Public Health; Research; Research Institute; Research Project Grants; Resources; Role; Services; Superfund; Targeted Research; Techniques; Technology; Toxic effect; Translating; Translational Research; Translations; Universities; Water; college; novel; nutrition; programs; remediation; superfund chemical

The University of Kentucky Superfund Basic Research Program will focus on the environmental health impacts of chlorinated organics with a more specific focus on RGBs and TCE. The Program will include five separate biomedical research projects that seek to better understand the biochemical and cellular mechanisms associated with exposure to such chemicals, as well as the associated impacts on such diseases as cancer, diabetes, hypertension, and cardiovascular disease, i.e. diseases common in Kentucky. One of the unique aspects of the research program will be the investigation of the role of nutrition in mitigating the impacts associated with such exposures. In addition, separate projects will examine the use of nanotechnologies and biosensors in detecting such chemicals in the environment and will explore novel techniques for remediation, with a particular focus on groundwater contaminated by TCE. The latter project will have specific potential for application as a result of ongoing remediation studies associated with the Gaseous Diffusion Plant in Paducah, Kentucky. The Research Translation Core will translate Program research to five targeted audiences: Government, Industry, Broad Audiences, Health Professionals, and Academia. Consistent with the guidelines of the RFA, the specific aims of the Research Translation Core are summarized as follows: 1. Communicate important research outcomes to specific targeted audiences to ensure the accurate and timely use of the knowledge and technologies generated by individual research projects, thus contributing to the reduction of environmental contamination and the improvement of public health. Specific target audiences include: a) government, b) academia, industry and health professionals and c) broad audiences (including the general public and impacted communities). 2. Leverage research translation activities and targeted research translation projects through effective partnerships and other communication tools. Specific partnerships include: 1) The Kentucky Water Resources Research Institute, 2) The Kentucky Research Consortium for Energy and Environment, 3) The Kentucky Cooperative Extension Service, 4) UK College of Communications and Information Studies, 5) UK Center for Clinical and Translational Science, and 6) Other SBRP Research Translation Cores, (see attached letters of support) 3. Develop and implement a mechanism for tracking and evaluating the effectiveness of the translated research to confirm the utility and appropriateness of the communication tools selected. These efforts, promoted through eight specific translation projects, will contribute to a reduction in environmental contamination, an increase in target audiences' knowledge about the relationship between Superund chemical exposure and health outcomes, and a subsequent improvement in human health.

肯塔基大学超级基金基础研究计划将重点关注环境健康 氯化有机物的影响，更具体地侧重于RGB和TCE。该计划将包括五个 独立的生物医学研究项目，寻求更好地了解生化和细胞 与接触这类化学品有关的机制以及对这些化学品的影响 癌症、糖尿病、高血压和心血管疾病，即肯塔基州的常见病。 该研究计划的一个独特方面将是调查营养在 减轻与这种暴露相关的影响。此外，单独的项目将检查使用 纳米技术和生物传感器检测环境中的此类化学物质，并将探索新的 补救技术，特别侧重于受三氯乙烯污染的地下水。后一个项目 将具有特定的应用潜力，这是与 位于肯塔基州帕迪尤卡的气体扩散工厂。研究翻译核心将翻译程序 针对五个目标受众的研究：政府、行业、广大受众、卫生专业人员和 学术界。与RFA的指导方针一致，研究翻译核心的具体目标是 摘要如下： 1.将重要的研究成果传达给特定的目标受众，以确保准确和 及时利用个别研究项目产生的知识和技术，从而促进 减少环境污染，改善公众健康。特定目标 受众包括：a)政府、b)学术界、工业界和卫生专业人员以及c)广大受众。 (包括普通公众和受影响社区)。 2.通过有效利用科研翻译活动和有针对性的科研翻译项目 伙伴关系和其他沟通工具。具体的合作伙伴包括：1)肯塔基水务 资源研究所，2)肯塔基州能源和环境研究联盟，3) 肯塔基州合作推广服务，4)英国通信与信息研究学院，5)英国 临床和翻译科学中心，以及6)其他SBRP研究翻译核心，(参见 附寄的支持信) 3.制定和实施跟踪和评估翻译效果的机制 研究以确认所选沟通工具的实用性和适当性。 这些努力，通过八个具体的翻译项目来促进，将有助于减少 环境污染，增加了目标受众对 超常化学物质暴露和健康后果，以及随后对人类健康的改善。