Core C: Research Translation Core

肯塔基州大学超级基金基础研究项目将重点关注环境健康 本报告还介绍了氯化有机物的影响，特别侧重于RGB和TCE。该计划将包括五个 独立的生物医学研究项目，旨在更好地了解生物化学和细胞 与接触此类化学品相关的机制，以及对此类化学品的相关影响， 癌症、糖尿病、高血压、心血管疾病等肯塔基州常见的疾病。 该研究计划的一个独特方面将是调查营养在以下方面的作用： 减轻与此类暴露相关的影响。此外，个别项目将审查使用 纳米技术和生物传感器检测环境中的此类化学品，并将探索新的 （c）在环境保护方面，应特别注意受三氯乙烯污染的地下水。后一个项目 将具有特定的应用潜力，因为正在进行的补救研究与 肯塔基州帕迪尤卡的气体扩散工厂。研究翻译核心将翻译程序 研究面向五个目标受众：政府、行业、广大受众、卫生专业人员和 学术界。根据RFA的指导方针，研究翻译核心的具体目标是 摘要如下： 1.将重要的研究成果传达给特定的目标受众，以确保 及时利用个别研究项目产生的知识和技术，从而有助于 减少环境污染和改善公众健康。特定目标 受众包括：a）政府，B）学术界、工业界和卫生专业人员，以及c）广大受众 （包括公众和受影响的社区）。 2.通过有效的研究翻译活动和有针对性的研究翻译项目 伙伴关系和其他通信工具。具体合作伙伴关系包括：1）肯塔基州水务公司 资源研究所，2）肯塔基州能源与环境研究联盟，3） 肯塔基州合作推广服务，4）英国传播与信息研究学院，5）英国 临床和转化科学中心，以及6）其他SBRP研究翻译核心（见 附支持信） 3.制定和实施一个机制，跟踪和评价翻译后的 进行研究，以确认所选通信工具的实用性和适当性。 通过八个具体翻译项目推动的这些努力，将有助于减少 环境污染，增加目标受众对环境污染之间关系的了解， 超临界化学品暴露和健康结果，以及随后对人类健康的改善。

The University of Kentucky Superfund Basic Research Program will focus on the environmental health impacts of chlorinated organics with a more specific focus on RGBs and TCE. The Program will include five separate biomedical research projects that seek to better understand the biochemical and cellular mechanisms associated with exposure to such chemicals, as well as the associated impacts on such diseases as cancer, diabetes, hypertension, and cardiovascular disease, i.e. diseases common in Kentucky. One of the unique aspects of the research program will be the investigation of the role of nutrition in mitigating the impacts associated with such exposures. In addition, separate projects will examine the use of nanotechnologies and biosensors in detecting such chemicals in the environment and will explore novel techniques for remediation, with a particular focus on groundwater contaminated by TCE. The latter project will have specific potential for application as a result of ongoing remediation studies associated with the Gaseous Diffusion Plant in Paducah, Kentucky. The Research Translation Core will translate Program research to five targeted audiences: Government, Industry, Broad Audiences, Health Professionals, and Academia. Consistent with the guidelines of the RFA, the specific aims of the Research Translation Core are summarized as follows: 1. Communicate important research outcomes to specific targeted audiences to ensure the accurate and timely use of the knowledge and technologies generated by individual research projects, thus contributing to the reduction of environmental contamination and the improvement of public health. Specific target audiences include: a) government, b) academia, industry and health professionals and c) broad audiences (including the general public and impacted communities). 2. Leverage research translation activities and targeted research translation projects through effective partnerships and other communication tools. Specific partnerships include: 1) The Kentucky Water Resources Research Institute, 2) The Kentucky Research Consortium for Energy and Environment, 3) The Kentucky Cooperative Extension Service, 4) UK College of Communications and Information Studies, 5) UK Center for Clinical and Translational Science, and 6) Other SBRP Research Translation Cores, (see attached letters of support) 3. Develop and implement a mechanism for tracking and evaluating the effectiveness of the translated research to confirm the utility and appropriateness of the communication tools selected. These efforts, promoted through eight specific translation projects, will contribute to a reduction in environmental contamination, an increase in target audiences' knowledge about the relationship between Superund chemical exposure and health outcomes, and a subsequent improvement in human health.