2012 CSHL Automated Imaging & High-Throughput Phenotyping Conference

描述(由申请人提供)：本提案寻求对2012年4月在冷泉港实验室举行的“自动成像和高分辨率成像”会议的支持。会议将召集该领域的领导者，以及初级教师、博士后研究员和研究生，讨论利用成像技术获取高通量表型的最新进展。这一领域处于将基因型映射到表型的努力的前沿。生物学中尚未解决的主要问题之一是基因型和表型之间的关系。要准确地将基因型映射到表型，将需要关于两者的详细的种群水平信息。虽然我们很快就有能力快速确定种群中个体的完整基因组，但我们描述其表型的能力受到限制。解决这一差距的努力侧重于增加 表型采集的吞吐量。这通常涉及自动化成像能力的开发。就其本质而言，这一领域的努力是高度跨学科的，因为TEY汇集了来自一系列定量学科的实验者、工程师和研究人员。会议将包括关于单细胞表型、发育表型、器官(ISMAL)/行为表型、显微镜和技术、数据挖掘、建模、管理和可视化的会议。每期会议将由该领域的一位顶尖科学家主持。口头发言将从会议主席与组织者协商后提交的摘要中挑选出来。选定的演讲者将包括研究生、博士后研究员和初级教职员工，旨在最大限度地纳入年轻研究人员。特别重要的是两个海报会议，许多与会者可以在有利于非正式讨论的气氛中介绍他们的工作。将邀请更多的高级调查人员突出重要或快速移动的地区。这次会议将是中等规模的，我们预计将有大约200人参加，其中绝大多数人将展示海报或演讲。 与公共卫生相关：很快就有可能快速、廉价地确定个体的基因组序列。基因组中的信息如何转化为有机体(构成其表型)的功能和外观的变化，目前还远不清楚。基因组差异导致的表型变化可能是有益的，也可能是有害的。就人类疾病而言，关于不同基因的变化如何影响疾病易感性，有很多需要了解的东西。要了解基因组中的信息如何映射到表型中的修饰，将需要开发高通量的表型测量方法。由于许多感兴趣的表型特征可以可视化，新的和增强的成像技术与自动成像能力相结合是这一新兴领域的先锋。这一领域的研究汇集了来自一系列定量学科的实验者、工程师和研究人员。拟于2012年4月在冷泉港实验室举行一次会议，题为“自动成像和高通量表型分析”，会议将召集一个跨学科的科学家小组，讨论这一领域的前沿方法和发现。

DESCRIPTION (provided by applicant): This proposal seeks support for the meeting on "AUTOMATED IMAGING AND HIGH TRHOUGHPUT" to be held at Cold Spring Harbor Laboratory April, 2012. The meeting will assemble leaders in the field, together with junior faculty, postdoctoral fellows and graduate students, to discuss the latest advances that make use of imaging for high throughput phenotype acquisition. This area is at the forefront of efforts to map genotype to phenotype. One of the major unresolved problems in biology is the relationship between genotype and phenotype. To accurately map genotype to phenotype will require detailed population-level information about both. While we will soon have the ability to rapidly determine the complete genomes of individuals in a population, we are limited by our ability to characterize their phenotypes. Efforts to address this disparity focus on increasing the throughput of phenotype acquisition. This usually involves the development of automated imaging capabilities. By their very nature, efforts in this field are highly interdisciplinary as tey bring together experimentalists, engineers and researchers from a range of quantitative disciplines. The meeting will include sessions on single cell phenotyping, developmental phenotyping, organ(ismal)/behavioral phenotyping, microscopy and technology, data mining, modeling, management, and visualization. Each session will be chaired by a leading scientist in the field. Oral presentations will be selected from submitted abstracts by the session chairs in consultation with the organizers. Selected speakers will include graduate students, postdoctoral fellows and junior faculty aiming for maximal inclusion of young investigators. Of special importance are the two poster sessions, where many participants can present their work in an atmosphere conducive to informal discussion. Additional senior investigators will be invited to highlight important or rapidly moving areas. The meeting will be of moderate size and we expect about 200 people to attend, the vast majority of whom will be presenting a poster or talk. PUBLIC HEALTH RELEVANCE: It will soon be possible to determine the genome sequence of an individual rapidly and inexpensively. How the information in the genome translates into changes in the functioning and appearance of an organism (which constitutes its phenotype) is far from clear. Phenotypic changes resulting from differences in the genome can be beneficial or harmful. In the case of human disease, there is much to be learned about how changes in different genes affect disease susceptibility. To understand how information in the genome maps to modifications in the phenotype will require the development of high-throughput means of measuring phenotypes. Because many phenotypic features of interest can be visualized, new and enhanced imaging techniques combined with automated imaging capabilities are at the vanguard of this emerging field. Research in this area brings together experimentalists, engineers and researchers from a range of quantitative disciplines. A meeting is proposed to be held at Cold Spring Harbor Laboratory in April 2012 entitled, "Automated Imaging & High-Throughput Phenotyping" that will bring together an interdisciplinary group of scientists to discuss cutting edge approaches and findings in this field.