权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

DNA & PROTEIN MICRO-ARRAY FACILITY (SHARED RESOURCE)

脱氧核糖核酸

基本信息

批准号：
8215290
负责人：
SUZANNE SANDMEYER
金额：
$ 5.13万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8215290
关键词：
Address Algorithms Aliquot Allegra Alleles Aventyl Biological Biology Books Cancer Center Support Grant Cells Church Client Cluster Analysis Complementary DNA Comprehensive Cancer Center Computer Workstations Computer software Computers Consultations Copy Number Polymorphism Core Facility Custom DNA Data Data Analyses Data Files Development Disease Elements Ensure Equipment Experimental Designs Faculty Filtration Gene Expression Gene Expression Profiling Genes Genetic Genetic Transcription Genome Genomics Genotype Glass Goals Head Histocompatibility Testing Imagery Individual Information Sciences Instruction Label Laboratories Lead Liquid substance Literature Loss of Heterozygosity Manuals Maps Measurement Methods Metric Microarray Analysis Mission Normal Cell Numerical value Occupations Oligonucleotides Online Systems Output Pathway interactions Pattern Phase Preparation Printing Procedures Process Protein Microchips Proteins Protocols documentation Publications Quality Control RNA RNA purification Reaction Research Research Design Research Methodology Research Personnel Resource Sharing Robot Robotics Running SNP genotyping Sampling Scanning Screening procedure Services Single Nucleotide Polymorphism Map Slide Speed Spottings Staging System Techniques Technology Testing Text Time Tissues University of California Irvine Cancer Center Vacuum Variant Work Writing analog base cancer cell computer science data modeling design diagnosis design digital disease diagnosis genome-wide insight interest meetings plasmid DNA programs research study sample collection sound statistics success tool

项目摘要

The UCI DMA & Protein MicroArray Facility was initially established in 1999 as a Comprehensive Cancer Center Shared Resource Core Facility, directed at assisting both North and South Campus investigators performing microarray expression analysis. About 200 investigators inside and outside the South Campus have been provided services in the last five year period. We primarily utilize the Affymetrix GeneChip array system to monitor gene expression and perform SNP/genotype mapping. Our mission is to provide RNA expression and genomic DMA analysis in a consistent and timely manner that is of the highest quality for all of our Facility's users. In addition to providing experimental expertise for performing gene expression and SNP/genotype mapping protocols, the staff provides advice and consultation on experimental design, and data analysis approaches and statistics for microarray based research. Currently, the primary use of this technology is to determine the differential expression patterns of genes, either within cells or tissues. This technology enables investigators to compare patterns of expression in diseased and normal cells, cancer cells and non-cancerous cells and in different tissue types. The goal of these types of studies is to better understand the processes that potentially lead to diseased states and to find new or better ways of either controlling or stopping the progression of diseased states. A rapidly increasing use of this technology is analysis of genotypic variants (SNPs) to map disease-causing genes. These types of approaches will provide insight into multifactorial disease states. Genomewide information unlike individual gene information can be used to understand the more subtle patterns of diseases caused by multiple genes or by the confluence of environmental and genetic factors. Because of the great amount of detailed information provided from genomewide arrays, it is likely that microarrays will become an even more important tool not only in understanding disease processes, but also in disease diagnosis and the design of individualized therapies.

UCI DMA和蛋白质微阵列设施最初成立于1999年，是一个综合癌症研究中心