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From Lead Compounds to Potential Therapeutics: Drugs to Treat Clostridium Difficile Infections

From Lead Compounds to Potential Therapeutics: Drugs to Treat Clostridium Difficile Infections
从先导化合物到潜在治疗药物:治疗艰难梭菌感染的药物
批准号:
nhmrc : 1124032
负责人:
Prof Dena Lyras
金额:
$35.72万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2017
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2017-01-01 至 2020-12-31

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中文摘要
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英文摘要
Clostridium difficile infection (CDI) attacks the gut resulting in diarrhoea and inflammation of the colon. It is classified as the number one antibiotic-resistant bacterial threat in the USA where there are 500,000 cases of CDI and 30,000 deaths. CDI is an increasing problem for hospitalized patients in the US, the EU and Australia. Our recent NHMRC funded project established drug leads against CDI and we now require continued studies to develop our drug leads towards marketable therapeutics.
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会议论文
Understanding how bacteria adapt and function in the complex gut ecosystem
  • 批准号:
    FL210100258
  • 项目类别:
    Australian Laureate Fellowships
  • 资助金额:
    $224.17万
  • 财政年份:
    2022
  • 负责人:
    Prof Dena Lyras
  • 依托单位:
Mechanism of secretion of large clostridial toxins
  • 批准号:
    DP210103374
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $44.51万
  • 财政年份:
    2021
  • 负责人:
    Prof Dena Lyras
  • 依托单位:
A link between antibiotic resistance and bacterial sporulation
  • 批准号:
    DP190102969
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $30.95万
  • 财政年份:
    2019
  • 负责人:
    Prof Dena Lyras
  • 依托单位:
Mechanism of action of a novel multifunctional bacterial secretion system
  • 批准号:
    DP180102449
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $28.88万
  • 财政年份:
    2018
  • 负责人:
    Prof Dena Lyras
  • 依托单位:
海外基金