From Lead Compounds to Potential Therapeutics: Drugs to Treat Clostridium Difficile Infections
From Lead Compounds to Potential Therapeutics: Drugs to Treat Clostridium Difficile Infections
批准号:
nhmrc : 1124032
负责人:
Prof Dena Lyras
金额:
$35.72万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2017
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2017-01-01 至 2020-12-31
中文摘要
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英文摘要
Clostridium difficile infection (CDI) attacks the gut resulting in diarrhoea and inflammation of the colon. It is classified as the number one antibiotic-resistant bacterial threat in the USA where there are 500,000 cases of CDI and 30,000 deaths. CDI is an increasing problem for hospitalized patients in the US, the EU and Australia. Our recent NHMRC funded project established drug leads against CDI and we now require continued studies to develop our drug leads towards marketable therapeutics.
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Understanding how bacteria adapt and function in the complex gut ecosystem
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财政年份:2018
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依托单位:
Global regulatory networks that control virulence in Clostridium perfringens
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项目类别:Project Grants
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财政年份:2017
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负责人:Prof Dena Lyras
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依托单位:
Global regulatory networks that control virulence in Clostridium perfringens
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批准号:nhmrc : GNT1125349
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资助金额:$53.16万
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负责人:Prof Dena Lyras
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依托单位:
From Lead Compounds to Potential Therapeutics: Drugs to Treat Clostridium Difficile Infections
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批准号:nhmrc : GNT1124032
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资助金额:$52.35万
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财政年份:2017
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负责人:Prof Dena Lyras
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依托单位:
The role of Clostridium difficile spore interactions with the host in gastrointestinal infection and disease
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资助金额:$35.07万
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财政年份:2016
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负责人:Prof Dena Lyras
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依托单位:
The role of Clostridium difficile spore interactions with the host in gastrointestinal infection and disease
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资助金额:$51.15万
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Environmental contamination and pig disease: an Australian microbe evolves
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财政年份:2015
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负责人:Prof Dena Lyras
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依托单位:
The Development Of Novel Antibacterials Targeting Clostridium Difficile Infections
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资助金额:$50.05万
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依托单位:
Molecular characterisation of hypervirulence and the infectious cycle in Clostridium difficile
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资助金额:$60.58万
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负责人:Prof Dena Lyras
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依托单位:
The development and evaluation of a new therapy for the prevention and treatment of bacterial infections in hospitals
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资助金额:$35.45万
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财政年份:2011
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负责人:Prof Dena Lyras
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依托单位:
The role of virulence factors of Clostridium difficile in food animals.
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批准号:DP1093891
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项目类别:Discovery Projects
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资助金额:$22.99万
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财政年份:2010
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负责人:Prof Dena Lyras
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依托单位:
Regulation of toxin production in Clostridium difficile
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项目类别:NHMRC Project Grants
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资助金额:$31.48万
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负责人:Prof Dena Lyras
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依托单位:
Functional biology of large serine recombinases from mobile antibiotic resistance elements
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财政年份:2007
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依托单位:
Pathogenesis of clostridial myonecrosis
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资助金额:$9.12万
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财政年份:2003
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负责人:Prof Dena Lyras
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依托单位:
Functional biology of clostridial transposons
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批准号:nhmrc : 194228
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项目类别:NHMRC Project Grants
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海外基金