Mechanism of secretion of large clostridial toxins

该项目旨在研究大型梭状芽胞杆菌毒素是如何从重要的动物细菌病原体中分泌出来的。该项目希望利用一种协作和跨学科的方法和尖端技术，产生关于细菌如何通过蛋白质分泌与宿主相互作用的新知识。该项目的预期成果包括建立对出口机制在细菌毒素分泌中的作用的深入了解，以及确定实现这一点的新系统。这将带来重大好处，例如对新的细菌蛋白质输出机制有新的见解，目的是确定未来兽医疾病干预或生物技术应用的目标。

This project aims to investigate how the large clostridial toxins are secreted from important animal bacterial pathogens. This project expects to generate new knowledge about how bacteria interact with hosts through protein secretion, using a collaborative and interdisciplinary approach and cutting-edge techniques. Expected outcomes of this project include building a deep understanding of the role of export machinery in toxin secretion from bacteria, and the identification of new systems by which this is achieved. This should provide significant benefits, such as gaining new insights into new bacterial protein export mechanisms, with the aim of identifying targets for future veterinary disease interventions or biotechnological applications.