Mechanism of secretion of large clostridial toxins

大梭菌毒素的分泌机制

• 批准号: DP210103374
• 负责人: Prof Dena Lyras
• 金额: $ 44.51万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210103374
• 关键词: Mechanism; secretion; large; clostridial; toxins

This project aims to investigate how the large clostridial toxins are secreted from important animal bacterial pathogens. This project expects to generate new knowledge about how bacteria interact with hosts through protein secretion, using a collaborative and interdisciplinary approach and cutting-edge techniques. Expected outcomes of this project include building a deep understanding of the role of export machinery in toxin secretion from bacteria, and the identification of new systems by which this is achieved. This should provide significant benefits, such as gaining new insights into new bacterial protein export mechanisms, with the aim of identifying targets for future veterinary disease interventions or biotechnological applications.

本项目旨在研究重要动物病原菌如何分泌梭菌大毒素。该项目预计将产生关于细菌如何通过蛋白质分泌与宿主相互作用的新知识，使用协作和跨学科的方法和尖端技术。该项目的预期成果包括深入了解出口机制在细菌毒素分泌中的作用，并确定实现这一目标的新系统。这将带来重大益处，例如获得对新细菌蛋白质输出机制的新见解，目的是确定未来兽医疾病干预或生物技术应用的目标。