The role of Clostridium difficile spore interactions with the host in gastrointestinal infection and disease

艰难梭菌孢子与宿主相互作用在胃肠道感染和疾病中的作用

• 批准号: nhmrc : 1107969
• 负责人: Prof Dena Lyras
• 金额: $ 35.07万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-clostridium-difficile-infection-disease/663012
• 关键词: role; Clostridium; difficile; spore; interactions

Hospital-acquired infections with the bacterium Clostridium difficile are a major global public health concern with highly virulent isolates emerging overseas in 2002 and in Australia in 2010. These have spread through our hospitals and are also found in the community. This project will increase our understanding of how these strains cause severe gut disease, which is critical for the development of improved strategies for preventing and treating these infections and reducing antibiotic use.

医院获得性艰难梭菌感染是一个主要的全球公共卫生问题，2002年在海外和2010年在澳大利亚出现了高毒性分离株。这些疾病在我们的医院蔓延，在社区也有发现。该项目将增加我们对这些菌株如何导致严重肠道疾病的理解，这对于制定预防和治疗这些感染以及减少抗生素使用的改进策略至关重要。