Bedside-to-Bench Research Training for Pediatric Infectious Diseases Fellows

描述（由申请人提供）：摘要：我们在这项新的 T32 提案“儿科传染病研究员的床边到工作台研究培训”中的主要目标是培训高技能的学术医生，进行与对婴儿和儿童具有全球重要性的传染病相关的转化研究。该计划的长期目标是培训儿科医师科学家，他们将成为 NIH 资助的、精通多学科研究计划的研究人员。我们申请的标题反映了我们将重点放在让受训者成为儿科传染病专家，以便在开始研究培训之前能够管理复杂的患者群体。这一目标将通过在第一年的培训中为学员在双城儿童医院提供丰富多样的住院和门诊临床经验来实现。第一年之后，将提供两年的研究支持，以对病原体和病原体与宿主相互作用进行深入的、有指导的调查。指导培训将在明尼苏达大学最近成立的传染病和微生物学转化研究中心 (CIDMTR) 进行。 CIDMTR 是一个协作性多部门机构，由来自微生物学、儿科和内科的研究人员组成。 CIDMTR 微生物学系附属教师也将担任 T32 的导师。在被确定为导师或潜在导师的 27 名研究人员中，有 11 名是儿科医生或在儿科拥有主要任命。具有独立 NIH 资助和培训经验的核心高级教师团队将被指定为该项目的主要导师。 CIDMTR 的研究人员在对儿童具有全球健康意义的传染病方面拥有强大的转化研究项目，包括疱疹病毒、疟疾、结核病、沙门氏菌和艾滋病毒感染。 T32 学者将有更多机会与基因组学、药理学、兽医学、流行病学和临床试验领域的专家进行交流。研究员选择在转化轨道或基础科学轨道上进行研究。在这两个途径中，我们制定了计划，以确保研究员获得进行独立转化研究所需的科学背景和调查技能。无论哪种方式，研究员都有机会攻读研究生课程。研究员可以注册为微生物学研究生课程的非入学研究生，或攻读转化研究项目的新颖硕士学位。保障措施将确保研究生工作不会干扰受保护的研究时间。每年需要两个医学博士后研究员名额。奖学金监督委员会和由 NIH 资助的儿科研究人员组成的外部咨询委员会将监督 T32 学者的进展。我们预计，我们的学员将做好独特的准备，在其学术研究生涯中领导儿科传染病的转化研究项目。 公共卫生相关性：项目叙述 传染病继续在全球婴儿和儿童中造成相当大的发病率和死亡率。迫切需要将基础研究成果转化为更有效的疾病控制干预措施，包括疫苗等预防策略和新型抗菌干预措施。一群拥有丰富研究经验、经验丰富的导师将教育儿科传染病医生如何对对全世界儿童至关重要的传染病进行转化研究。

DESCRIPTION (provided by applicant): Abstract: Our primary objective in this new T32 proposal, "Bedside-to-Bench Research Training for Pediatric Infectious Diseases Fellows" is to train highly skilled academic physicians in translational research relevant to infectious diseases of global importance to infants and children. The long-term goal of the program is to train pediatric physician-scientists who will become NIH-funded investigators skilled in multidisciplinary research initiatives. The title of our application reflects the emphasis that will be placed on preparing trainees to become pediatric infectious disease experts capable of managing complex patient populations prior to initiation of research training. This goal will be realized by providing trainees in the first year of fellowship with intense and diverse inpatient and outpatient clinical experiences in children's hospitals in the Twin Cities. Following the first year, two years of research support will be provided for intense, mentored investigation of pathogens and pathogen-host interactions. Mentored training will take place at the recently opened Center for Infectious Diseases and Microbiology Translational Research (CIDMTR) at the University of Minnesota. The CIDMTR is a collaborative, multi-departmental facility consisting of investigators from the Departments of Microbiology, Pediatrics, and Internal Medicine. CIDMTR-affiliate faculty in the Department of Microbiology will also be mentors on the T32. Of the 27 investigators identified as mentors or prospective mentors, 11 are pediatricians or have a primary appointment in the Department of Pediatrics. A core group of senior faculty with independent NIH funding and training experience will be designated as primary mentors for this program. Investigators at the CIDMTR have strong translational research programs in infectious diseases of global health significance to children, including herpesviruses, malaria, tuberculosis, salmonella, and HIV infection. Additional opportunities will be available for T32 scholars to interface with experts in genomics, pharmacology, veterinary medicine, epidemiology, and clinical trials. Fellows elect to pursue research in a translational track, or a basic science track. Within both pathways, we have developed programs to ensure that fellows will acquire the scientific background and investigative skills necessary to conduct independent translational research. In either track, fellows have opportunities to pursue a graduate course work. Fellows may register as nonmatriculated graduate students in microbiology graduate course work, or pursue a novel Master's in Translational Research program. Safeguards will ensure that graduate work does not interfere with protected time to perform research. Two MD post-doctoral fellow slots/year are requested. A Scholarship Oversight Committee and an external advisory committee of NIH-funded pediatric investigators will monitor progress of the T32 scholars. We anticipate that our trainees will be uniquely well prepared to lead translational investigative programs in pediatric infectious diseases in their academic research careers. PUBLIC HEALTH RELEVANCE: Project Narrative Infectious diseases continue to extract considerable morbidity and mortality in infants and children globally. There is a major need to translate basic research findings into more effective disease control interventions, including preventative strategies such as vaccines, and novel antimicrobial interventions. A group of experienced mentors with extensive research experience will educate pediatric infectious diseases physicians in how to conduct translational research on infectious diseases that are of importance to children throughout the world.