Bedside-to-Bench Research Training for Pediatric Infectious Diseases Fellows

描述(由申请者提供)：摘要：在这项新的T32提案中，我们的主要目标是“儿科传染病研究员的床边到工作台研究培训”，目的是培训高技能的学术医生，从事与对婴儿和儿童具有全球重要性的传染病相关的翻译研究。该计划的长期目标是培养儿科医生和科学家，他们将成为NIH资助的研究人员，擅长多学科研究。我们申请的标题反映了在开始研究培训之前，将把重点放在培养受训人员成为能够管理复杂患者群体的儿科传染病专家上。这一目标将通过在团契第一年为学员提供密集和多样化的住院和门诊临床经验来实现，这些医院位于双子城的儿童医院。在第一年之后，将为病原体和病原体-宿主相互作用的密集、有指导的调查提供两年的研究支持。指导培训将在明尼苏达大学最近开设的传染病和微生物学翻译研究中心(CIDMTR)进行。CIDMTR是一个协作的、多部门的机构，由来自微生物学、儿科和内科的研究人员组成。CIDMTR微生物系的附属教员也将成为T32的导师。在27名被确认为导师或潜在导师的调查人员中，有11人是儿科医生或在儿科部门有初步任命。拥有独立NIH资助和培训经验的高级教员核心团队将被指定为该项目的主要导师。CIDMTR的研究人员在对儿童具有全球健康意义的传染病方面拥有强大的翻译研究计划，包括疱疹病毒、疟疾、结核病、沙门氏菌和艾滋病毒感染。T32学者将有更多机会与基因组学、药理学、兽医、流行病学和临床试验方面的专家交流。研究员选择在翻译轨道或基础科学轨道上进行研究。在这两条道路上，我们都制定了计划，以确保研究员将获得进行独立翻译研究所需的科学背景和调查技能。在任何一条道路上，研究员都有机会继续攻读研究生课程。研究员可以注册为微生物学研究生课程的非录取研究生，或者攻读一个新的翻译研究硕士课程。保障措施将确保研究生工作不会干扰受保护的进行研究的时间。每年需要两个医学博士后研究员的名额。由NIH资助的儿科研究人员组成的奖学金监督委员会和外部咨询委员会将监督T32学者的进展。我们预计，我们的学员将在他们的学术研究生涯中，为领导儿科传染病方面的翻译调查项目做好独特的准备。 公共卫生相关性：项目叙述传染病继续在全球婴儿和儿童中造成相当大的发病率和死亡率。主要需要将基本研究成果转化为更有效的疾病控制干预措施，包括疫苗等预防性战略和新型抗微生物干预措施。一组具有丰富研究经验的经验丰富的导师将教育儿科传染病医生如何对世界各地的儿童重要的传染病进行翻译研究。

DESCRIPTION (provided by applicant): Abstract: Our primary objective in this new T32 proposal, "Bedside-to-Bench Research Training for Pediatric Infectious Diseases Fellows" is to train highly skilled academic physicians in translational research relevant to infectious diseases of global importance to infants and children. The long-term goal of the program is to train pediatric physician-scientists who will become NIH-funded investigators skilled in multidisciplinary research initiatives. The title of our application reflects the emphasis that will be placed on preparing trainees to become pediatric infectious disease experts capable of managing complex patient populations prior to initiation of research training. This goal will be realized by providing trainees in the first year of fellowship with intense and diverse inpatient and outpatient clinical experiences in children's hospitals in the Twin Cities. Following the first year, two years of research support will be provided for intense, mentored investigation of pathogens and pathogen-host interactions. Mentored training will take place at the recently opened Center for Infectious Diseases and Microbiology Translational Research (CIDMTR) at the University of Minnesota. The CIDMTR is a collaborative, multi-departmental facility consisting of investigators from the Departments of Microbiology, Pediatrics, and Internal Medicine. CIDMTR-affiliate faculty in the Department of Microbiology will also be mentors on the T32. Of the 27 investigators identified as mentors or prospective mentors, 11 are pediatricians or have a primary appointment in the Department of Pediatrics. A core group of senior faculty with independent NIH funding and training experience will be designated as primary mentors for this program. Investigators at the CIDMTR have strong translational research programs in infectious diseases of global health significance to children, including herpesviruses, malaria, tuberculosis, salmonella, and HIV infection. Additional opportunities will be available for T32 scholars to interface with experts in genomics, pharmacology, veterinary medicine, epidemiology, and clinical trials. Fellows elect to pursue research in a translational track, or a basic science track. Within both pathways, we have developed programs to ensure that fellows will acquire the scientific background and investigative skills necessary to conduct independent translational research. In either track, fellows have opportunities to pursue a graduate course work. Fellows may register as nonmatriculated graduate students in microbiology graduate course work, or pursue a novel Master's in Translational Research program. Safeguards will ensure that graduate work does not interfere with protected time to perform research. Two MD post-doctoral fellow slots/year are requested. A Scholarship Oversight Committee and an external advisory committee of NIH-funded pediatric investigators will monitor progress of the T32 scholars. We anticipate that our trainees will be uniquely well prepared to lead translational investigative programs in pediatric infectious diseases in their academic research careers. PUBLIC HEALTH RELEVANCE: Project Narrative Infectious diseases continue to extract considerable morbidity and mortality in infants and children globally. There is a major need to translate basic research findings into more effective disease control interventions, including preventative strategies such as vaccines, and novel antimicrobial interventions. A group of experienced mentors with extensive research experience will educate pediatric infectious diseases physicians in how to conduct translational research on infectious diseases that are of importance to children throughout the world.