Mayo Clinic Center for Translational Science Activities

描述(申请人提供)：梅奥诊所CTSA的总体目标是继续在梅奥诊所建立一个基础广泛的综合临床和转化科学之家(CTS)，最终改善人类健康。在这种背景下，我们寻求使Mayo CTSA及其利用的资源成为临床和转化研究的效率引擎，同时也是创新的驱动力。我们还寻求将我们的当地活动与旨在协调和调整的财团范围内的努力结合起来。为了实现我们的目标，我们为这次更新制定了六个主要的具体目标：目标1-培养和保持一支杰出的多学科临床和翻译科学队伍。这支队伍包括调查人员和支持人员组成的团队。目标2--消除翻译工作中的障碍。这将通过a)继续努力精简监管和合规，b)为调查人员提供出色的设计、生物统计和道德支持，以及c)进一步整合支助服务来实现。目标3-与提供者和社区合作，改善医疗保健提供和社区健康。这包括对以实践为基础的研究、社区参与的研究以及将比较有效性研究转化为临床实践的实质性承诺。目标4-部署先进的设施和其他核心资源，以增加临床研究的价值。在这种情况下，价值被定义为质量和成本的商，目标是提高质量，降低成本，并为临床和转化性研究的全范围提供资源。目标5--通过有针对性地支持创新试点和可行性研究并促进新方法的开发，鼓励新的研究方向和方法。目标6-利用信息学整合和促进临床和转化性研究。这包括广泛的信息学视野，包括：a)为CTS开发标准化的电子数据捕获和分析工具；b)利用Mayo对电子临床系统的承诺，为医学信息学提供强大的咨询和工具；以及c)生物信息学服务和能力，将有助于促进将“新生物学”应用于临床和转译研究。这一愿景与梅奥诊所所宣称的使命完全一致：“通过综合临床实践、教育和研究，每天为每一位患者提供最佳护理。” 公共卫生相关性(由申请者提供)：梅奥临床转化科学活动中心将汇集梅奥临床医学院五所学校的所有资源和100多年的科学和医学研究专业知识，以发现创新的新方法，将研究成果转化为治疗方法、工具和患者护理实践，通过改善当地和国家社区的健康来影响他们。

DESCRIPTION (provided by applicant): The overall goal of the Mayo Clinic CTSA is to continue to build a broad-based and integrated home for clinical and translational science (CTS) at Mayo Clinic that will ultimately improve human health. In this context, we seek to make the Mayo CTSA and the resources it leverages both an engine of efficiency for clinical and translational research and at the same time a driver of innovation. We also seek to integrate our local activities with consortium wide efforts directed at coordination and alignment. To achieve our goal we have six overarching specific aims for this renewal: Aim 1 - Train and maintain an outstanding multidisciplinary clinical and translational sciences workforce. This workforce includes teams of both investigators and support staff. Aim 2 - Eliminate barriers to the work of translation. This will be accomplished through a) continued efforts at regulatory and compliance streamlining, b) provision of outstanding design, biostatistics, and ethics support for investigators, and c) further integration of support services. Aim 3 - Collaborate with providers and communities to improve health care delivery and community health. This includes substantial commitments to practice-based research, community- engaged research and translating comparative effectiveness research into clinical practice. Aim 4 - Deploy advanced facilities and other core resources to increase the value of clinical research. With value defined in this context as the quotient of quality and cost, the goal is to increase quality, decrease costs, and provide resources to the full spectrum of clinical and translational investigation. Aim 5 - Stimulate novel research directions and methodologies by targeted support of innovative pilot and feasibility studies and fostering the development of novel methodologies. Aim 6 - Employ informatics to integrate and facilitate clinical and translational investigation. This encompasses a broad view of informatics including: a) developing a standardized electronic data capture and analysis tools for CTS, b) robust consultation and tools for medical informatics that leverage Mayo's commitments to electronic clinical systems, and c) bioinformatics services and capabilities that will help facilitate the application of the "new biology" to clinical and translational investigation. This vision is entirely consistent with the stated mission of Mayo Clinic: "To provide the best care to every patient every day through integrated clinical practice, education, and research." PUBLIC HEALTH RELEVANCE (provided by applicant): Mayo Clinic Center for Translational Science Activities will bring together all the resources of the five schools within the Mayo Clinic College of Medicine and more than 100 years of scientific and medical research expertise, to discover innovative new methods that will speed the translation of research results into therapies, tools, and patient care practices that impact both our local and national communities by improving their health.