N-CANDA: Data Analysis Component

N-CANDA：数据分析组件

• 批准号: 8413194
• 负责人: Adolf Pfefferbaum
• 金额: $ 82.44万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-15 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8413194
• 关键词: Abstinence; Address; Adolescence; Adolescent; Adolescent Development; Adverse effects; Affect; Affective; Age; Alcohol abuse; Alcohol consumption; Alcohol or Other Drugs use; Alcoholism; Alcohols; Anatomy; Archives; Atlases; Behavioral inhibition; Biological Neural Networks; Brain; Brain imaging; Clinical; Clinical Data; Clinical assessments; Cognitive; Collection; DNA; Data; Data Analyses; Databases; Deposition; Detection; Development; Diffusion Magnetic Resonance Imaging; Dose; Ensure; Family history of; Fiber; Functional Magnetic Resonance Imaging; Future; Heavy Drinking; High Prevalence; Image; Image Analysis; Informatics; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Mediating; Mining; Monitor; Neurocognitive; Neuropsychological Tests; Pattern; Performance; Physiologic pulse; Physiological; Physiology; Procedures; Process; Protocols documentation; Psychopathology; Quality Control; Recovery; Regulation; Research; Research Infrastructure; Research Personnel; Resolution; Rest; Retrieval; Rewards; Risk Factors; Role; Sampling; Science; Site; Sleep; Sleep Stages; Structure; System; Testing; Time; alcohol abstinence; alcohol effect; alcohol exposure; alcohol use disorder; base; computerized data processing; data integration; data mining; design; disorder risk; heavy drinking during adolescence; imaging modality; longitudinal design; neurodevelopment; neuroimaging; neuropsychological; programs; prospective; psychologic; relating to nervous system; response; sex; underage drinking; white matter; young adult

DESCRIPTION (provided by applicant): The National Consortium on Alcohol and NeuroDevelopment in Adolescence (N-CANDA) proposes a longitudinal study of developmental trajectories of brain structure, function, and physiology and their alteration by adolescent alcoho exposure. The prospective design will assess young people before the start of any significant substance use, thereby facilitating identification of antecedent conditions influencing the development of Alcohol Use Disorder (AUD) and the effects thereafter. A synergistic program to assess dependent-variable domains (clinical, neuropsychological, physiological, brain structural and functional), quantified and tracked longitudinally will be combined across 4 collection sites to create a large and rich body of data. An accelerated longitudinal design allows for construction of trajectories over the entire adolescent age range and encompasses the period of brain structural and functional development during the vulnerable time of AUD emergence. The investigators of the N- CANDA Data Analysis, Integration, and Informatics Component will provide fundamental neuroimaging science support for MRI pulse sequence development, acquisition, and analysis protocols. This component will also provide the infrastructure for deposition, organization, storage, archiving, retrieval, and initial analysis of neuroimaging, neuropsychological, and clinical data collected at all four N- CANDA acquisition sites. The Specific Aims of the Data Analysis, Integration, and Informatics Component are to: Aim 1. Develop procedures for collection of neuroimaging, neuropsychological, and clinical assessment data harmonized with existing large-scale neurodevelopmental research efforts. Aim 2. Ensure that quality control measures are in place at each site for the acquisition of imaging data. Aim 3. Develop the informatics infrastructure for data submission, database construction, data analysis, integration, and distribution for all N-CANDA sites through a query system that allows exploration of the multiple domains of the database. Aim 4. Provide a pipeline for macrostructural, microstructural and functional neuroimage data processing and analysis. Aim 5. Develop informatics processes to coordinate the combining of data and the analysis of results across and within research components for a priori hypothesis testing and association discovery and atheoretical data mining in search of relations not previously considered. ! PUBLIC HEALTH RELEVANCE: Because of the high prevalence of adolescent alcohol consumption, the National Consortium on Alcohol and NeuroDevelopment in Adolescence (N-CANDA) proposes a longitudinal study of a large group of adolescents before they begin excessive alcohol use. This component brings together all neuroimaging, neuropsychological, and clinical data collected at multiple sites for analysis and detection of the deleterious effectsof alcohol abuse on the development of the adolescent brain. !

描述（由申请人提供）：国家青少年酒精和神经发育联盟（N-CANDA）提出了一项纵向研究，研究大脑结构、功能和生理学的发育轨迹及其因青少年酒精暴露而发生的变化。前瞻性设计将在年轻人开始大量使用药物之前对其进行评估，从而有助于识别影响酒精使用障碍（AUD）发展的先期条件及其后的影响。一个评估因变量领域（临床、神经心理学、生理学、大脑结构和功能）、纵向量化和跟踪的协同计划将跨 4 个收集站点进行组合，以创建大量丰富的数据。加速的纵向设计允许在整个青少年年龄范围内构建轨迹，并涵盖 AUD 出现的脆弱时期的大脑结构和功能发育时期。 N-CANDA 数据分析、集成和信息学部分的研究人员将为 MRI 脉冲序列开发、采集和分析协议提供基础神经影像科学支持。该组件还将为在所有四个 N-CANDA 采集站点收集的神经影像、神经心理学和临床数据的沉积、组织、存储、归档、检索和初步分析提供基础设施。数据分析、整合和信息学部分的具体目标是： 目标 1. 开发收集神经影像、神经心理学和临床评估数据的程序，与现有的大规模神经发育研究工作相协调。目标 2. 确保每个站点都采取成像数据采集的质量控制措施。目标3。 通过允许探索数据库多个领域的查询系统，开发所有 N-CANDA 站点的数据提交、数据库构建、数据分析、集成和分发的信息学基础设施。目标 4. 提供宏观结构、微观结构和功能神经图像数据处理和分析的管道。目标 5. 开发信息学流程，以协调研究组件之间和内部的数据组合和结果分析，以进行先验假设检验、关联发现和非理论数据挖掘，以寻找先前未考虑的关系。 ！ 公共健康相关性：由于青少年饮酒的普遍性，国家青少年酒精和神经发育联盟 (N-CANDA) 建议在大量青少年开始过量饮酒之前对他们进行一项纵向研究。该组件汇集了在多个地点收集的所有神经影像学、神经心理学和临床数据，用于分析和检测酒精滥用对青少年大脑发育的有害影响。 ！