N-CANDA: Data Analysis Component

描述（由申请人提供）：国家青少年酒精和神经发育联盟（N-CANDA）提出了一项纵向研究，研究青少年酒精暴露对大脑结构、功能和生理的发育轨迹及其变化。前瞻性设计将在开始使用任何重要物质之前对年轻人进行评估，从而有助于确定影响酒精使用障碍（AUD）发展的先决条件及其影响。一个协同计划，以评估依赖变量域（临床，神经心理，生理，大脑结构和功能），量化和纵向跟踪将在4个收集站点组合，以创建一个大而丰富的数据体。加速纵向设计允许在整个青少年年龄范围内构建轨迹，并包括AUD出现的脆弱时间期间的大脑结构和功能发育时期。N-CANDA数据分析、集成和信息学组件的研究者将为MRI脉冲序列开发、采集和分析协议提供基本的神经成像科学支持。该组件还将为在所有四个N-CANDA采集站点收集的神经影像学、神经心理学和临床数据的沉积、组织、存储、存档、检索和初步分析提供基础设施。数据分析，集成和信息学组件的具体目标是：目标1。制定收集神经影像学、神经心理学和临床评估数据的程序，与现有的大规模神经发育研究工作相协调。目标二。确保每个研究中心都有质量控制措施来采集成像数据。目标3： 开发信息学基础设施，用于数据提交、数据库构建、数据分析、集成和通过查询系统分发所有N-CANDA站点，该查询系统允许探索数据库的多个域。目标4。为宏观结构、微观结构和功能神经影像数据处理和分析提供管道。目标5。发展信息学过程，以协调数据的组合和跨研究组成部分和内部的结果分析，以进行先验假设检验和关联发现，并进行非理论数据挖掘，以寻找以前没有考虑过的关系。! 公共卫生相关性：由于青少年饮酒的高流行率，国家酒精和青少年神经发育联盟（N-CANDA）提出了一个纵向研究的一大群青少年之前，他们开始过度饮酒。该部分汇集了在多个地点收集的所有神经影像学，神经心理学和临床数据，用于分析和检测酒精滥用对青少年大脑发育的有害影响。!

DESCRIPTION (provided by applicant): The National Consortium on Alcohol and NeuroDevelopment in Adolescence (N-CANDA) proposes a longitudinal study of developmental trajectories of brain structure, function, and physiology and their alteration by adolescent alcoho exposure. The prospective design will assess young people before the start of any significant substance use, thereby facilitating identification of antecedent conditions influencing the development of Alcohol Use Disorder (AUD) and the effects thereafter. A synergistic program to assess dependent-variable domains (clinical, neuropsychological, physiological, brain structural and functional), quantified and tracked longitudinally will be combined across 4 collection sites to create a large and rich body of data. An accelerated longitudinal design allows for construction of trajectories over the entire adolescent age range and encompasses the period of brain structural and functional development during the vulnerable time of AUD emergence. The investigators of the N- CANDA Data Analysis, Integration, and Informatics Component will provide fundamental neuroimaging science support for MRI pulse sequence development, acquisition, and analysis protocols. This component will also provide the infrastructure for deposition, organization, storage, archiving, retrieval, and initial analysis of neuroimaging, neuropsychological, and clinical data collected at all four N- CANDA acquisition sites. The Specific Aims of the Data Analysis, Integration, and Informatics Component are to: Aim 1. Develop procedures for collection of neuroimaging, neuropsychological, and clinical assessment data harmonized with existing large-scale neurodevelopmental research efforts. Aim 2. Ensure that quality control measures are in place at each site for the acquisition of imaging data. Aim 3. Develop the informatics infrastructure for data submission, database construction, data analysis, integration, and distribution for all N-CANDA sites through a query system that allows exploration of the multiple domains of the database. Aim 4. Provide a pipeline for macrostructural, microstructural and functional neuroimage data processing and analysis. Aim 5. Develop informatics processes to coordinate the combining of data and the analysis of results across and within research components for a priori hypothesis testing and association discovery and atheoretical data mining in search of relations not previously considered. ! PUBLIC HEALTH RELEVANCE: Because of the high prevalence of adolescent alcohol consumption, the National Consortium on Alcohol and NeuroDevelopment in Adolescence (N-CANDA) proposes a longitudinal study of a large group of adolescents before they begin excessive alcohol use. This component brings together all neuroimaging, neuropsychological, and clinical data collected at multiple sites for analysis and detection of the deleterious effectsof alcohol abuse on the development of the adolescent brain. !