N-CANDA: Data Analysis Component

描述(由申请人提供)：国家酒精与青春期神经发育联合会(N-CANDA)建议对大脑结构、功能和生理的发育轨迹以及青少年接触酒精后的变化进行纵向研究。这项前瞻性设计将在开始使用任何重要物质之前对年轻人进行评估，从而有助于识别影响酒精使用障碍(AUD)发展的前驱条件和之后的影响。一个评估依赖变量领域(临床、神经心理、生理、大脑结构和功能)、量化和纵向跟踪的协同计划将在4个收集地点合并，以创建大量和丰富的数据。加速的纵向设计允许在整个青少年年龄范围内构建轨迹，并包括在AUD出现的脆弱时期的大脑结构和功能发展时期。N-Canda数据分析、集成和信息学部门的研究人员将为MRI脉冲序列开发、采集和分析协议提供基本的神经成像科学支持。该组成部分还将为在所有四个N-Canda采购点收集的神经成像、神经心理学和临床数据的存储、组织、存储、存档、检索和初步分析提供基础设施。数据分析、集成和信息学部分的具体目标是：目标1.制定与现有大规模神经发育研究工作相协调的神经成像、神经心理学和临床评估数据的收集程序。目标2.确保每个地点都有质量控制措施，以获取成像数据。目标3. 通过一个允许探索数据库多个领域的查询系统，为所有N-Canda站点开发数据提交、数据库建设、数据分析、集成和分发的信息基础设施。目的4.为宏观、微观和功能神经影像数据的处理和分析提供一条管道。目的5.开发信息学程序，协调在研究组成部分之间和内部的数据组合和结果分析，以进行先验假设检验和关联发现，并进行理论数据挖掘，以寻找以前没有考虑过的关系。好了！ 公共卫生相关性：由于青少年饮酒的高流行率，全国青少年酒精与神经发育联盟(N-Canda)建议在青少年开始过度饮酒之前对他们进行一项纵向研究。这一组成部分汇集了在多个地点收集的所有神经成像、神经心理学和临床数据，用于分析和检测酒精滥用对青少年大脑发育的有害影响。好了！

DESCRIPTION (provided by applicant): The National Consortium on Alcohol and NeuroDevelopment in Adolescence (N-CANDA) proposes a longitudinal study of developmental trajectories of brain structure, function, and physiology and their alteration by adolescent alcoho exposure. The prospective design will assess young people before the start of any significant substance use, thereby facilitating identification of antecedent conditions influencing the development of Alcohol Use Disorder (AUD) and the effects thereafter. A synergistic program to assess dependent-variable domains (clinical, neuropsychological, physiological, brain structural and functional), quantified and tracked longitudinally will be combined across 4 collection sites to create a large and rich body of data. An accelerated longitudinal design allows for construction of trajectories over the entire adolescent age range and encompasses the period of brain structural and functional development during the vulnerable time of AUD emergence. The investigators of the N- CANDA Data Analysis, Integration, and Informatics Component will provide fundamental neuroimaging science support for MRI pulse sequence development, acquisition, and analysis protocols. This component will also provide the infrastructure for deposition, organization, storage, archiving, retrieval, and initial analysis of neuroimaging, neuropsychological, and clinical data collected at all four N- CANDA acquisition sites. The Specific Aims of the Data Analysis, Integration, and Informatics Component are to: Aim 1. Develop procedures for collection of neuroimaging, neuropsychological, and clinical assessment data harmonized with existing large-scale neurodevelopmental research efforts. Aim 2. Ensure that quality control measures are in place at each site for the acquisition of imaging data. Aim 3. Develop the informatics infrastructure for data submission, database construction, data analysis, integration, and distribution for all N-CANDA sites through a query system that allows exploration of the multiple domains of the database. Aim 4. Provide a pipeline for macrostructural, microstructural and functional neuroimage data processing and analysis. Aim 5. Develop informatics processes to coordinate the combining of data and the analysis of results across and within research components for a priori hypothesis testing and association discovery and atheoretical data mining in search of relations not previously considered. ! PUBLIC HEALTH RELEVANCE: Because of the high prevalence of adolescent alcohol consumption, the National Consortium on Alcohol and NeuroDevelopment in Adolescence (N-CANDA) proposes a longitudinal study of a large group of adolescents before they begin excessive alcohol use. This component brings together all neuroimaging, neuropsychological, and clinical data collected at multiple sites for analysis and detection of the deleterious effectsof alcohol abuse on the development of the adolescent brain. !