N-CANDA: Data Analysis Component

描述（由申请人提供）：全国青少年酒精和神经发育联合会（n - canada）提出了一项关于青少年酒精暴露对大脑结构、功能和生理发育轨迹及其改变的纵向研究。前瞻性设计将在任何重大物质使用开始之前对年轻人进行评估，从而促进识别影响酒精使用障碍（AUD）发展的先决条件及其影响。一个协同程序，以评估因变量领域（临床，神经心理学，生理，大脑结构和功能），量化和纵向跟踪将在4个收集点结合起来，以创建一个庞大而丰富的数据体。加速纵向设计允许在整个青少年年龄范围内构建轨迹，并包括在AUD出现的脆弱时期的大脑结构和功能发育时期。N- canada数据分析、集成和信息学部分的研究人员将为MRI脉冲序列的开发、获取和分析协议提供基础神经成像科学支持。该组件还将提供基础设施，用于沉积、组织、存储、存档、检索和初步分析在所有四个N- canada采集点收集的神经影像学、神经心理学和临床数据。数据分析、集成和信息学组件的具体目标是：目标1。制定收集神经影像学、神经心理学和临床评估数据的程序，与现有的大规模神经发育研究工作相协调。目标2。确保质量控制措施在每个地点到位，以获取成像数据。目标3。

DESCRIPTION (provided by applicant): The National Consortium on Alcohol and NeuroDevelopment in Adolescence (N-CANDA) proposes a longitudinal study of developmental trajectories of brain structure, function, and physiology and their alteration by adolescent alcoho exposure. The prospective design will assess young people before the start of any significant substance use, thereby facilitating identification of antecedent conditions influencing the development of Alcohol Use Disorder (AUD) and the effects thereafter. A synergistic program to assess dependent-variable domains (clinical, neuropsychological, physiological, brain structural and functional), quantified and tracked longitudinally will be combined across 4 collection sites to create a large and rich body of data. An accelerated longitudinal design allows for construction of trajectories over the entire adolescent age range and encompasses the period of brain structural and functional development during the vulnerable time of AUD emergence. The investigators of the N- CANDA Data Analysis, Integration, and Informatics Component will provide fundamental neuroimaging science support for MRI pulse sequence development, acquisition, and analysis protocols. This component will also provide the infrastructure for deposition, organization, storage, archiving, retrieval, and initial analysis of neuroimaging, neuropsychological, and clinical data collected at all four N- CANDA acquisition sites. The Specific Aims of the Data Analysis, Integration, and Informatics Component are to: Aim 1. Develop procedures for collection of neuroimaging, neuropsychological, and clinical assessment data harmonized with existing large-scale neurodevelopmental research efforts. Aim 2. Ensure that quality control measures are in place at each site for the acquisition of imaging data. Aim 3. Develop the informatics infrastructure for data submission, database construction, data analysis, integration, and distribution for all N-CANDA sites through a query system that allows exploration of the multiple domains of the database. Aim 4. Provide a pipeline for macrostructural, microstructural and functional neuroimage data processing and analysis. Aim 5. Develop informatics processes to coordinate the combining of data and the analysis of results across and within research components for a priori hypothesis testing and association discovery and atheoretical data mining in search of relations not previously considered. ! PUBLIC HEALTH RELEVANCE: Because of the high prevalence of adolescent alcohol consumption, the National Consortium on Alcohol and NeuroDevelopment in Adolescence (N-CANDA) proposes a longitudinal study of a large group of adolescents before they begin excessive alcohol use. This component brings together all neuroimaging, neuropsychological, and clinical data collected at multiple sites for analysis and detection of the deleterious effectsof alcohol abuse on the development of the adolescent brain. !