International Research Collaboration on Neuroimaging Studies of Alcoholism

酒精中毒神经影像学国际研究合作

• 批准号: 8814979
• 负责人: Adolf Pfefferbaum
• 金额: $ 27.9万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8814979
• 关键词: Accounting; Alcohol Amnestic Disorder; Alcohol consumption; Alcoholism; Alcohols; Award; Basic Science; Behavioral; Biological; Biological Markers; Blood; Brain; Chronic; Cognitive; Collaborations; Country; DSM-V; Data; Data Analyses; Data Collection; Diagnostic; Doctor of Medicine; Doctor of Philosophy; Episodic memory; Ethnic Origin; Fiber; Folic Acid; France; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Genes; Genetic Markers; Genotype; Hematocrit procedure; Hemoglobin; Heterogeneity; Hippocampus (Brain); Homocysteine; Homocystine; Hospitals; Human; International; Korea; Koreans; Laboratories; Magnetic Resonance Imaging; Measures; Memory; Motor; NIH Program Announcements; National Institute on Alcohol Abuse and Alcoholism; Nervous system structure; Neuraxis; Neuropsychology; Neurosciences; Nutritional; Nutritional status; Outcomes Research; Patients; Pattern; Principal Investigator; Procedures; Protocols documentation; Recording of previous events; Recovery; Red Blood Cell Count; Relative (related person); Research; Research Personnel; Rest; Risk Factors; Scientist; Secure; Single Nucleotide Polymorphism; Site; South Korea; Structure; System; Testing; Thalamic structure; Therapeutic; Thiamine; Thiamine Pyrophosphate; Translational Research; U-Series Cooperative Agreements; United States; Universities; Variant; Visit; Wernicke-Korsakoff Syndrome; Whole Blood; Work; Writing; addiction; alcohol effect; brain volume; cerebrovascular; genetic variant; indexing; interest; mean corpuscular volume observed; neuroimaging; neuropsychological; nutrition; problem drinker; programs; public health relevance; relating to nervous system; response

DESCRIPTION (provided by applicant): This application for a competing renewal of a U01 cooperative agreement award is written in response to Program Announcement (PA) number PAR-11-282, "International Research Collaboration on Alcohol and Alcoholism." Receipt of this award would enable us to continue a program of international collaborations among the well-established nationally funded research groups at INSERM/University of Caen site in France directed by Francis Eustache, Ph.D., the recently-established addictions research program at the Yonsei University affiliated Severance Hospital in Seoul, South Korea directed by Young-Chul Jung, M.D., Ph.D., and our longstanding neuroimaging and neuroscience laboratories funded principally by NIAAA, in the United States at Stanford University with Edith Sullivan, Ph.D., Principal Investigator (MPI) and at SRI International with Adolf Pfefferbaum, M.D. (MPI). The overarching aim of this collaboration is 1) to use neuroimaging, neuropsychology, and biomarkers of nutrition in alcoholics, with and without KS, and controls to compare and contrast the effects of alcohol on brain structure and function across nations and 2) to identify markers of nutritional status, genetic variants, and alcohol consumption patterns that modulate the principal dependent measures and explain heterogeneity in presentation and recovery of alcoholism. Three specific aims with testable hypotheses are proposed: 1. Prospectively screen with common diagnostic DSM-V criteria 100 alcoholics, 100 controls, and 10 KS in each country-U.S., France, and South Korea-and acquire the following data: 1a. Neuroimaging (MRI, FLAIR, DTI, and rs-fMRI) data using common protocols developed over the current funding period. 1b. Neuropsychological data using the common long and newly developed short test batteries. 1c. Blood for analysis of biomarkers of nutritional status (hemogram for red blood cell count, hematocrit, hemoglobin, mean corpuscular volume; vitamin B1 (whole blood thiamine diphosphate), folate, B12 and cerebrovascular risk factor (homocysteine). 1.d. Blood for analysis of thiamine transporter genotyping 2. Implement a secure pipeline for data reception, storage, analysis, and dissemination to and from project sites. 3. Conduct data analysis and hypothesis testing in collaboration with the project scientists (French and Korean visiting the U.S. and U.S. visiting France and Korea) and export results and analysis procedures to France and Korea.

描述(由申请人提供)：本U01合作协议奖的竞争性续签申请书是针对项目公告(PA)编号PAR-11-282“国际酒精和酒精中毒研究合作”而写的。获得这一奖项将使我们能够继续在法国INSERM/卡昂大学网站由Francis Eustache博士指导的久负盛名的国家资助研究小组之间开展国际合作计划，在韩国首尔延世大学附属Severance医院最近建立的由Young-Chul Jung医学博士指导的成瘾研究计划，以及我们主要由NIAAA资助的长期神经成像和神经科学实验室，在美国斯坦福大学与Edith Sullivan博士合作，与首席研究员Edith Sullivan博士合作，在SRI国际与Adolf Pefferbaum医学博士合作。这项合作的首要目标是1)使用神经成像、神经心理学和营养生物标记物，在有和没有KS的酗酒者和对照中比较和对比不同国家酒精对大脑结构和功能的影响；2)确定 营养状况、遗传变异和酒精消费模式调节了主要的依赖指标，并解释了酒精中毒表现和康复的异质性。本研究提出了三个具有可验证性假设的具体目标：1.采用DSM-V通用诊断标准对美国、法国和韩国各100名酗酒者、100名对照和10名KS进行前瞻性筛查，并获得以下数据：神经成像(核磁共振、FLAIR、DTI和RS-fMRI)数据，使用在当前资助期开发的通用协议。1B.神经心理学数据使用普通的长的和新开发的短的测试电池。1C。血液用于分析营养状况的生物标志物(血象包括红细胞计数、红细胞压积、血红蛋白、平均红细胞体积；维生素B1(全血硫胺素二磷酸)、叶酸、B12和脑血管危险因子(同型半胱氨酸))。1.D.用于分析硫胺素转运体基因分型的血液2.为数据的接收、存储、分析和从项目现场传播实施安全的管道。3.与项目科学家(法国和韩国访问美国，美国访问法国和韩国)合作进行数据分析和假设检验，并将结果和分析程序输出到法国和韩国。