Cold Spring Harbor Laboratory 2010 Conference of Vertebrate Organogenesis

冷泉港实验室2010年脊椎动物器官发生会议

• 批准号: 8241615
• 负责人: DAVID J. STEWART
• 金额: $ 0.6万
• 依托单位: COLD SPRING HARBOR LABORATORY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8241615
• 关键词: Academia; Address; Animal Model; Area; Basic Science; Biological; Biological Models; Biomedical Research; Cell Therapy; Clinical; Collaborations; Data; Development; Developmental Biology; Disease; Doctor of Philosophy; Embryonic Development; Engineering; Environment; European; Experimental Models; Faculty; Fostering; Future; Genes; Genetic; Genomics; Goals; Health; Industry; International; Laboratories; Molecular; Molecular Genetics; Mus; Natural regeneration; Oral; Organ; Organogenesis; Participant; Pharmaceutical Preparations; Postdoctoral Fellow; Process; Rana; Recording of previous events; Research; Research Institute; Research Personnel; Scientist; Stem cells; Students; System; Tissues; Translational Research; Woman; Work; Zebrafish; abstracting; base; graduate student; interest; meetings; optimism; posters; repaired; stem cell biology; success; symposium; systems research

SUMMARY/ABSTRACT One of the goals of modern biomedical research is to promote the repair and regeneration of damaged tissues and organs. This includes the engineering or grafting of replacement tissues from stem cells and the enhancement of endogenous repair processes. In order to achieve this goal we need a detailed understanding of how normal organs are assembled during embryonic development. In addition, we need to know more about changes in damaged tissues and the consequences of abnormal development. Recent advances in stem cell biology are impressive, and have strengthened our collective optimism that gene and stem cell-based therapies may eventually become realistic approaches in the treatment of many diseases, particularly those that have a significant pathological effect on specific organs. Central to that goal is a clear understanding of the genes and mechanisms controlling vertebrate organogenesis in health and disease, and a meeting focusing on those topics is long due. A number of meetings and symposia dealing with developmental biology are held around the world every year. However, none of those focus exclusively on vertebrate organogenesis, nor do they combine speakers covering both normal development and pathological changes associated with organ damage and disease. Meetings sponsored by the Cold Spring Harbor Laboratory have a history of being the forum where new discoveries, concepts, and scientific connections are presented. The proposed inaugural conference will set the standards to continue with this meeting in a two years basis. The organizers expect this conference to become the reference meeting "to attend" by those working in related topics. This conference aims to provide a forum in which basic and disease-oriented researchers working in various animal models in diverse aspects of organ development can present their latest findings as well as an overview of the field in normal and pathological conditions. In this setting, the conference will provide the opportunity for an important exchange of information and ideas among basic scientists, clinical fellows, and scientists working in biotech companies, and ideally, help to establish fruitful collaborations. Six major topics have been chosen for detailed discussion, each including basic and disease-oriented presentations, as a reflection of the most advanced and interesting areas of study in development & disease. These topics are all ultimately united by the use of approaches that pursue answers to key biological questions. A clear demonstration of the interest on this type of conference is the fact that the organizers have already managed to confirm the participation of an outstanding list of speakers that includes most of the leaders on each of the organs/tissues to be discussed at this conference.

摘要/摘要 现代生物医学研究的目标之一是促进受损组织和器官的修复和再生。这包括从干细胞的工程或嫁接替代组织以及内源性修复过程的增强。为了实现这一目标，我们需要详细了解在胚胎开发过程中如何组装正常器官。此外，我们需要更多地了解受损组织的变化以及异常发育的后果。干细胞生物学的最新进展令人印象深刻，并增强了我们的集体乐观情绪，即基因和基于干细胞的疗法最终可能成为许多疾病治疗的现实方法，尤其是那些对特定器官具有重要病理作用的疾病。该目标的核心是对控制健康和疾病中脊椎动物器官发生的基因和机制的清晰理解，而关注这些主题的会议很长。每年在世界各地举行许多有关发育生物学的会议和研讨会。但是，这些都不专注于脊椎动物器官发生，也没有结合涵盖与器官损伤和疾病相关的正常发育和病理变化的扬声器。冷泉港实验室赞助的会议有一个历史，是提出新发现，概念和科学联系的论坛。拟议的就职会议将设定标准，以在两年的基础上继续进行这次会议。组织者希望这次会议成为相关主题的人“参加”的参考会议。这次会议旨在提供一个论坛，在该论坛上，在各种动物模型中工作的基本和疾病的研究人员可以介绍他们的最新发现，以及在正常和病理条件下对该领域的概述。在这种情况下，会议将为基础科学家，临床研究员以及从事生物技术公司工作的科学家之间进行重要的信息和思想提供机会，理想情况下，有助于建立富有成果的合作。选择了六个主要主题进行详细讨论，每个讨论包括基本和疾病的演讲，以反映开发与疾病中最先进，最有趣的研究领域。这些主题最终都是通过使用回答关键生物学问题的方法来结合的。对这种类型会议的兴趣的明确证明是，组织者已经设法确认了一份出色的演讲者名单的参与，其中包括在本次会议上要讨论的每个器官/组织上的大多数领导者。