Project 1: Endocrine Disruptors & Obesity Among Inner-City Children

项目一：内分泌干扰物

• 批准号: 8322716
• 负责人: Andrew G Rundle
• 金额: $ 19.43万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8322716
• 关键词: 5 year old; Adolescent; Adult; African American; Age; Area; Aromatic Polycyclic Hydrocarbons; Asthma; Birth; Blood Cells; Body Composition; Body Size; Body mass index; Cardiovascular Diseases; Child; Childhood; Communities; Data; Dependence; Development; Dominican; Endocrine Disruptors; Environmental Health; Epidemic; Epigenetic Process; Exposure to; Fatty acid glycerol esters; Food; Gender; Genes; Genetic; Grant; Growth; Height; Heritability; Human; Hunger; Intervention; Life; Link; Malignant Neoplasms; Measures; Mediating; Metabolic syndrome; Methylation; Minority; Mothers; New York City; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Population; Pregnancy; Public Health; Research; Risk; Sampling; Technology; Testing; Umbilical cord structure; United States; Urine; Weight; Weight Gain; air sampling; bisphenol A; cohort; early adolescence; early childhood; early life exposure; inner city; lipid biosynthesis; obesity in children; offspring; postnatal; prenatal; prenatal exposure; public health priorities

The specific aims are to evaluate whether prenatal and early-life exposures to the endocrine disruptors, bisphenol A (BPA) and polycyclic aromatic hydrocarbons (PAH), during pregnancy and early-childhood are associated with obesity and metabolic syndrome among children during early adolescence. The research will be conducted within the ongoing longitudinal birth cohort of African American and Dominican children from inner-city communities in New York City being conducted by the Columbia Center for Children's Environmental Health. BPA and PAH exposures are widespread among cohort mothers and children. Both compounds have been linked to obesity and metabolic syndrome in experimental and preliminary human studies. The research is timely; childhood obesity is increasing rapidly within the United States, with rates highest among minority populations. By age 5 years, 43% of our cohort children exceed the 85% of weight for age. The epidemic is likely to have significant public health implications, particularly among minority populations, as obesity is linked to risk of type 2 diabetes and cardiovascular disease. We propose to follow the children in the cohort to age 8-10 years and will assess height, weight, and body composition at ages 5, 7 and 8-10 years and metabolic syndrome components at ages 8-10. Exposure dosimeters are PAH concentrations in maternal prenatal personal air samples and PAH and BPA metaboltites concentrations in urine samples collected and stored from the mother during pregnancy and from the child at ages 3,5, and 7 years. We hypothesize that prenatal exposure to PAH and BPA (1) will be associated with higher weight gain trajectories from age 5 to 8-10, and at age 8-10 years with BMI z-score, fat mass and metabolic syndrome components and (2) will alter the methylation status of key genes involved in adipogenesis and hunger control measured in umbilical cord while blood cells, which will mediate the association between postnatal exposures to the endocrine disruptors and childhood obesity outcomes. The research will provide important data on whether prenatal/early-life expsoures to endocrine disruptors predicts childhood obesity/metabolic syndrome and will test hypotheses regarding underlying epigenentic mechansisms.

具体目的是评估产前和生命早期是否接触内分泌干扰物， 双酚 A (BPA) 和多环芳烃 (PAH) 在怀孕期间和幼儿期 与青春期早期儿童的肥胖和代谢综合征有关。该研究将 在来自非洲裔美国人和多米尼加儿童的持续纵向出生队列中进行 哥伦比亚儿童中心对纽约市内城区社区进行了调查 环境健康。 BPA 和 PAH 暴露在同龄母亲和儿童中普遍存在。两个都 在实验和初步人类实验中，化合物与肥胖和代谢综合征有关 研究。研究及时；在美国，儿童肥胖症正在迅速增加，发病率 少数民族人口中最高。到 5 岁时，我们队列中 43% 的儿童体重超过了 85% 对于年龄。这种流行病可能会对公共卫生产生重大影响，特别是对少数族裔 人群，因为肥胖与 2 型糖尿病和心血管疾病的风险有关。我们建议遵循 队列中的儿童年龄为 8-10 岁，并将在 5 岁时评估身高、体重和身体成分， 7 岁和 8-10 岁以及 8-10 岁代谢综合征的组成部分。暴露剂量计为 PAH 母亲产前个人空气样本中的浓度以及 PAH 和 BPA 代谢物浓度 收集并储存怀孕期间母亲以及 3、5 和 7 岁时孩子的尿液样本 年。我们假设产前接触 PAH 和 BPA (1) 与体重增加有关 获得从 5 岁到 8-10 岁以及 8-10 岁的 BMI z 分数、脂肪量和代谢轨迹 综合征的组成部分和（2）将改变参与脂肪生成的关键基因的甲基化状态， 饥饿控制在脐带和血细胞中测量，这将介导两者之间的关联 产后接触内分泌干扰物和儿童肥胖结果。该研究将提供 关于产前/生命早期接触内分泌干扰物是否预示童年的重要数据 肥胖/代谢综合征，并将测试有关潜在表观遗传机制的假设。