NEURAL BASIS OF SELF-MOTION PERCEPTION

自我运动感知的神经基础

• 批准号: 8470270
• 负责人: Dora Angelaki
• 金额: $ 31.67万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-01 至 2016-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8470270
• 关键词: Address; Anterior; Area; Behavioral; Bilateral; Cognitive; Cognitive deficits; Complex; Cues; Darkness; Data Set; Discrimination; Dorsal; Electric Stimulation; Environment; Eye; Goals; Hand; Head; Illusions; Image; Imaging Techniques; Individual; Knowledge; Lateral; Link; Macaca mulatta; Medial; Monkeys; Motion; Motion Perception; Movement; Neurons; Oral cavity; Pattern; Perception; Performance; Population; Positioning Attribute; Probability; Process; Property; Relative (related person); Reporting; Retina; Retinal; Rotation; Saccades; Self Perception; Signal Detection Analysis; Signal Transduction; Somatosensory Cortex; Space Perception; Stimulus; Techniques; Temporal Lobe; Testing; Training; Translations; Visual; Visual Cortex; Work; base; cognitive neuroscience; electrical microstimulation; eye center; intraparietal sulcus; labyrinthectomy; multisensory; optic flow; preference; relating to nervous system; research study; response; sample fixation; sensory integration; sensory neuroscience; somatosensory; ventral intraparietal area; virtual reality; visual information; visual optics; visual-vestibular

To navigate effectively through a complex three-dimensional environment, we must accurately estimate our own motion relative to the objects around us. Perception of self-motion is a multi-modal process, involving ntegration of visual, vestibular, and proprioceptive/somatosensory cues. For example, patterns of image motion across the retina ('optic flow') can be strong cues to self-motion, as evidenced by the fact that optic flow alone can elicit the illusion of self-motion (vection). We propose here to systematically explore a potential contribution of area 2v in the perception of translational and/or rotational self-motion and to directly compare these contributions to those of the ventral intraparietal area (VIP) and the dorsal subdivision of the medial superior temporal (MSTd) areas. Area 2v is one of the so-called 'vestibular' cortical areas with both vestibular and optic flow responsiveness, located in the most anterior and lateral tip of the intraparietal sulcus. Simultaneous behavioral and electrophysiological experiments will be carried out using rhesus monkeys in a state-of-the-art virtual reality apparatus. These studies will combine behavioral, cognitive, and neural analyses to address an important, yet underdeveloped, area of sensory and cognitive neuroscience: the mechanisms of multi-sensory integration underlying self-motion perception. We will be attacking this difficult problem using a combination of single unit recording, electrical microstimulation, inactivation and imaging techniques. Specific aims 1 and 2 will characterize the 3D tuning properties of neurons during optic flow stimulation alone (Visual condition), motion in darkness (Vestibular condition) and Combined combinations of the two cues. In addition, we will also characterize the reference frames of Visual or Vestibular signals. In aim 3, we will test for direct links between area 2v neuronal activity and self-motion perception using a fine motion direction discrimination task. Together, these studies will provide a vital test of the hypothesis that area 2v is part of the neural substrate for self-motion perception. The proposed studies aim at filling an apparent gap in knowledge, important for understanding and treating cognitive deficits of spatial perception.

为了有效地在复杂的三维环境中导航，我们必须准确地估计我们的 相对于我们周围物体的自身运动。自我运动的感知是一个多通道的过程，涉及 视觉、前庭和本体感觉/躯体感觉线索的整合。例如，图像的图案 穿过视网膜的运动(光流)可能是自我运动的强烈信号，这一事实证明了光学 光是心流就能引发自我运动(向后)的错觉。我们建议在这里系统地探索一种 2v区在平移和/或旋转自运动知觉中的潜在贡献 将这些贡献与腹侧顶内区(VIP)和大脑中脑脊束核的背侧亚区进行比较。 内侧上颞(MSTd)区。2v区是所谓的前庭皮质区之一，两者都有 前庭和视神经血流反应性，位于顶内最前面和最外侧尖端 沟槽。将使用恒河猴同时进行行为和电生理实验 猴子在最先进的虚拟现实设备中。这些研究将结合行为、认知和 神经分析，以解决感觉和认知神经科学中一个重要但不发达的领域： 自我运动知觉背后的多感觉整合机制。我们将对此进行攻击 使用单一单元记录、电微刺激、失活和 成像技术。具体的目标1和2将描述视觉过程中神经元的3D调谐特性 单独的流动刺激(视觉条件)、黑暗中的运动(前庭条件)和联合刺激 两条线索的组合。此外，我们还将描述可视或 前庭信号。在目标3中，我们将测试2v区神经元活动和自我运动之间的直接联系。 感知采用精细运动方向辨别任务。总而言之，这些研究将提供对 认为2v区是自我运动感知的神经底物的一部分的假说。建议进行的研究 旨在填补知识上的明显空白，这对理解和治疗认知缺陷很重要 空间感知。