Medical University of South Carolina - Cancer Center Support Grant

南卡罗来纳医科大学 - 癌症中心支持补助金

• 批准号: 8072105
• 负责人: Andrew S Kraft
• 金额: $ 140.13万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8072105
• 关键词: Medical; University; South; Carolina; Cancer

DESCRIPTION (provided by applicant): The Hollings Cancer Center (HCC) at the Medical University of South Carolina (MUSC) seeks National Cancer Institute (NCI) designation via the P30 Cancer Center Support Grant mechanism to support its mission to reduce the cancer burden in South Carolina and beyond. As South Carolina's leading academic medical center, MUSC has been charged and supported over the past decade to build clinical, basic, translational and population-based research programs that address the state's significant cancer morbidity and mortality. Through the support of an NCI P20 Planning Grant (2001-2007), the HCC has recruited and organized 97 cancer scientists, representing six MUSC Colleges - Medicine, Pharmacy, Dental Medicine, Nursing, Health Professions and Graduate Studies - into productive and collaborative cancer research programs. These programs are: Lipid Signaling in Cancer, Cancer Genes & Molecular Regulation, Developmental Cancer Therapeutics and Cancer Immunology. A Cancer Prevention & Control program is in development. The HCC has expanded and continues to expand its research facilities and resources to enhance further growth. In 2006, the HCC completed a seven story tower adjacent to its original 85,761 ft[2] building adding more than 116,000 ft2 in research, clinical and administrative space, and MUSC has committed an additional 62,000 ft2 of research space to the HCC in two new buildings starting construction in summer 2008. As part of this P30 application, five shared research resources will be presented: Lipidomics, Flow Cytometry & Cell Sorting, Cell & Molecular Imaging, Biostatistics and Clinical Trials. The HCC has invested $1.6 million since 2004 into enhancing these five essential and critical resources. Given the rapid and ongoing development of research in the programs, the HCC has also invested another $6 million in initiating the development and optimizing the function of seven other shared resources that will greatly impact on HCC's current and future programmatic-based research initiatives. These investments have resulted in a doubling of the HCC's extramural research funding base since 2003, currently $31.2 million with NCI funding representing $12.1million. Accrual to therapeutic clinical trials has quadrupled in the same time period. This application demonstrates that HCC scientists have made significant contributions to the understanding of cancer biology and the development of novel approaches to prevent, diagnose and treat cancer.

描述(由申请人提供)：南卡罗来纳医科大学霍林斯癌症中心(HCC)寻求通过P30癌症中心支持赠款机制指定国家癌症研究所(NCI)，以支持其减少南卡罗来纳州及其他地区癌症负担的使命。作为南卡罗来纳州领先的学术医疗中心，MUSC在过去十年中一直负责和支持建立临床、基础、转换和基于人群的研究项目，以解决该州严重的癌症发病率和死亡率问题。在NCI P20规划补助金(2001-2007)的支持下，癌症研究中心招募并组织了97名癌症科学家，代表六所MUSC学院-医学、药学、牙医、护理、健康专业和研究生研究-参与富有成效和协作的癌症研究项目。这些课程是：癌症中的脂质信号、癌症基因和分子调控、癌症发展治疗和癌症免疫学。一项癌症预防和控制计划正在制定中。该中心已扩大并继续扩大其研究设施和资源，以促进进一步的增长。2006年，在原85,761英尺[2]高的大楼旁建成了一座7层的大楼，增加了超过116,000平方英尺的研究、临床和行政空间，MUSC已承诺在2008年夏天开始建设的两座新大楼中，为肝细胞癌增加62,000平方英尺的研究空间。作为P30应用的一部分，将展示五个共享的研究资源：脂质组学、流式细胞术和细胞分类、细胞和分子成像、生物统计学和临床试验。自2004年以来，美国癌症委员会已投入160万美元来加强这五项基本和关键的资源。鉴于计划中研究的快速和持续发展，美国癌症委员会还投资了另外600万美元，以启动开发和优化其他7个共享资源的功能，这些资源将极大地影响美国癌症委员会目前和未来基于计划的研究计划。这些投资导致自2003年以来，肝细胞癌的校外研究资金基础翻了一番，目前为3120万美元，其中NCI的资金为1210万美元。在同一时期，治疗性临床试验的收益增加了四倍。这一应用表明，肝癌科学家在了解癌症生物学和开发预防、诊断和治疗癌症的新方法方面做出了重大贡献。