CELL AND MOLECULAR IMAGING

细胞和分子成像

• 批准号: 8695817
• 负责人: Andrew S Kraft
• 金额: $ 7.26万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8695817
• 关键词: Animals; Bioluminescence; Cancer Center; Cancer Center Support Grant; Cells; Centers of Research Excellence; Consultations; Data Analyses; Development; Education; Emerging Technologies; Evaluation; Experimental Designs; Fluorescence; Functional Magnetic Resonance Imaging; Image; Imaging technology; Information Dissemination; Life; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Medical; Microscopic; Microscopy; Mission; NCI Center for Cancer Research; National Institute of General Medical Sciences; Preparation; Publications; Reliance; Research; Research Personnel; Research Support; Resource Sharing; Resources; Roentgen Rays; Sampling; Services; South Carolina; Techniques; Tissues; Training; Universities; anticancer research; base; cellular imaging; imaging modality; in vivo; insight; instrumentation; intravital imaging; meetings; member; molecular imaging; novel; pre-clinical; programs; research study; whole animal imaging

The mission of the Cell & Molecular Imaging (CMI) Shared Resource is to provide members of the Hollings Cancer Center (HCC) with a fully supported suite of state-of-the-art imaging capabilities. These capabilities include imaging at the cellular, tissue, intravital, and in vivo whole animal levels. Based on significant , expansion of capabilities and services to meet the growing needs of HCC investigators during the first CCSG project period, this resource, led by Dr. John J. Lemasters, Director, and Drs. Anna-Liisa Nieminen and Ann- Marie Broome, Associate Directors, has evolved significantly and now consists of two synergistic and coordinated units - the Confocal & Multiphoton Microscopy Unit and the Small Animal Imaging Unit The integration of these imaging approaches within one shared resource has been undertaken in recognition of the inter-reliance of the emerging techniques as well as the need for investigators to prospectively consider their imaging strategies to effectively transition their research from early cell and tissue studies to whole animal applications with preclinical impact. Since 2009, the CMI Shared Resource has supported research leading to more than 71 publications by 34 investigators representing all HCC research programs and seven MUSC departments. The specific purposes of the HCC CMI Shared Resource are to provide: ▪ Access to state-of-the-art confocal and multiphoton microscopy for imaging living cells in culture, intravital imaging in live animals, and in vivo small animal imaging, including MRI, fMRI, MR spectroscopy, microCT, microPET, bioluminescence, fluorescence, and X-ray. ▪ In depth training in multiple imaging modalities, including microscopic techniques, live cell imaging, multiphoton imaging, and pre-clinical in vivo animal imaging. ▪ Consultation and assistance concerning experimental design, sample preparation, probe selection, data analysis for imaging applications, and transitioning microscopic evaluations to whole animal imaging. Education in the fundamentals of imaging technology and its application, which are essential for appropriate utilization of these approaches, and dissemination of information concerning the ongoing development of novel experimental strategies, emerging technologies, and data analysis techniques.

细胞与分子成像（CMI）共享资源的使命是为霍林斯癌症中心（HCC）的成员提供一套完全支持的最先进的成像能力。这些能力包括细胞、组织、活体和活体全动物水平的成像。在第一个CCSG项目期间，为了满足HCC研究人员日益增长的需求，能力和服务得到了显著的扩展，这一资源由主任John J. Lemasters博士和dr。安娜-丽莎·尼米南和安-玛丽·布鲁姆，副主任，已经有了显著的发展，现在由两个协同和协调的单元组成——共聚焦和多光子显微镜单元和小动物成像单元。这些成像方法在一个共享资源中的整合已经进行，以认识到新兴技术的相互依赖，以及研究人员需要前瞻性地考虑他们的成像策略，以有效地将他们的研究从早期细胞和组织研究过渡到整个动物具有临床前影响的应用自2009年以来，CMI共享资源已经支持了代表所有HCC研究项目和7个MUSC部门的34名研究人员的71多篇论文。