CELL AND MOLECULAR IMAGING

细胞和分子成像

• 批准号: 8695817
• 负责人: Andrew S Kraft
• 金额: $ 7.26万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8695817
• 关键词: Animals; Bioluminescence; Cancer Center; Cancer Center Support Grant; Cells; Centers of Research Excellence; Consultations; Data Analyses; Development; Education; Emerging Technologies; Evaluation; Experimental Designs; Fluorescence; Functional Magnetic Resonance Imaging; Image; Imaging technology; Information Dissemination; Life; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Medical; Microscopic; Microscopy; Mission; NCI Center for Cancer Research; National Institute of General Medical Sciences; Preparation; Publications; Reliance; Research; Research Personnel; Research Support; Resource Sharing; Resources; Roentgen Rays; Sampling; Services; South Carolina; Techniques; Tissues; Training; Universities; anticancer research; base; cellular imaging; imaging modality; in vivo; insight; instrumentation; intravital imaging; meetings; member; molecular imaging; novel; pre-clinical; programs; research study; whole animal imaging

The mission of the Cell & Molecular Imaging (CMI) Shared Resource is to provide members of the Hollings Cancer Center (HCC) with a fully supported suite of state-of-the-art imaging capabilities. These capabilities include imaging at the cellular, tissue, intravital, and in vivo whole animal levels. Based on significant , expansion of capabilities and services to meet the growing needs of HCC investigators during the first CCSG project period, this resource, led by Dr. John J. Lemasters, Director, and Drs. Anna-Liisa Nieminen and Ann- Marie Broome, Associate Directors, has evolved significantly and now consists of two synergistic and coordinated units - the Confocal & Multiphoton Microscopy Unit and the Small Animal Imaging Unit The integration of these imaging approaches within one shared resource has been undertaken in recognition of the inter-reliance of the emerging techniques as well as the need for investigators to prospectively consider their imaging strategies to effectively transition their research from early cell and tissue studies to whole animal applications with preclinical impact. Since 2009, the CMI Shared Resource has supported research leading to more than 71 publications by 34 investigators representing all HCC research programs and seven MUSC departments. The specific purposes of the HCC CMI Shared Resource are to provide: ▪ Access to state-of-the-art confocal and multiphoton microscopy for imaging living cells in culture, intravital imaging in live animals, and in vivo small animal imaging, including MRI, fMRI, MR spectroscopy, microCT, microPET, bioluminescence, fluorescence, and X-ray. ▪ In depth training in multiple imaging modalities, including microscopic techniques, live cell imaging, multiphoton imaging, and pre-clinical in vivo animal imaging. ▪ Consultation and assistance concerning experimental design, sample preparation, probe selection, data analysis for imaging applications, and transitioning microscopic evaluations to whole animal imaging. Education in the fundamentals of imaging technology and its application, which are essential for appropriate utilization of these approaches, and dissemination of information concerning the ongoing development of novel experimental strategies, emerging technologies, and data analysis techniques.

细胞和分子成像（CMI）共享资源的任务是为Hollings癌症中心（HCC）的成员提供全面支持的最新成像功能。这些功能包括在细胞，组织，插入式和体内整个动物水平的成像。基于在第一个CCSG项目期间满足HCC调查人员需求不断增长的功能和服务的大量扩展，该资源由John J. Lemasters博士，董事和Drs。 Anna-Liisa Nieminen and Ann- Marie Broome, Associate Directors, has evolved significantly and now consists of two synergistic and coordinated units - the Confocal & Multiphoton Microscopy Unit and the Small Animal Imaging Unit The integration of these imaging approaches within one shared resource has been undertaken in recognition of the inter-reliance of the emerging techniques as well as the need for investigators to prospectively consider their imaging strategies为了有效地将其研究从早期的细胞和组织研究转变为具有临床前影响的整个动物应用。自2009年以来，CMI共享资源已支持34位代表所有HCC研究计划和七个MUSC部门的研究人员的71多个出版物。 HCC CMI共享资源的具体目的是提供： ▪进入最新的共聚焦和多光子显微镜，用于成像培养物中活细胞，活动物中的插入成像以及体内小动物成像，包括MRI，fMRI，MR Spectroscopicy，MR Spectroscopicy，Microct，MicroCT，Micropet，Micropet，生物发光，荧光，荧光，荧光和X射线。 ▪在多种成像方式的深度训练中，包括微观技术，活细胞成像， 多光子成像和体内动物成像的临床前。 ▪有关实验设计，样本制备，探针选择，成像应用的数据分析以及将微观评估转换为全动物成像的咨询和援助。 成像技术及其应用的基础知识的教育对于适当利用这些方法以及有关持续开发新型实验策略，新兴技术和数据分析技术的信息至关重要。