Biobehavioral characterization of infant rhesus monkeys

幼年恒河猴的生物行为特征

• 批准号: 8489678
• 负责人: JOHN P CAPITANIO
• 金额: $ 5.86万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-10 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8489678
• 关键词: Animals; Behavior; Behavioral; California; Characteristics; Chronic Disease; Data; Databases; Environment; Genes; Genetic Polymorphism; Genotype; Health; Human; Hypothalamic structure; Individual; Individual Differences; Infant; Macaca mulatta; Measures; Medicine; Memory; Mental Health; Modeling; Monoamine Oxidase A; Outcome; Outcome Measure; Participant; Personality; Personnel Management; Physiological; Pituitary-Adrenal System; Primates; Procedures; Promoter Regions; Protocols documentation; Qualifying; Regulation; Reproduction; Research; Resources; Risk; Rodent; Services; Social Functioning; Social Problems; Statistical Methods; Temperament; Testing; behavioral health; biobehavior; computerized data processing; design; improved; indexing; meetings; neuropsychiatry; nonhuman primate; novel; physical conditioning; prevent; primate development; programs; psychobiologic; public health relevance; reproductive; serotonin transporter; web interface; web page; willingness

DESCRIPTION (provided by applicant): Three decades of psychobiological research with rodents, nonhuman primates, and humans have documented the existence of individual differences in temperament, emotionality, behavioral and physiological reactivity, and personality, which we refer to as biobehavioral organization. These characteristics influence an individual's style of adaptation to its environment, and evidence shows that the quality of the animal's adaptations is associated with indices of psychological and physical health. At the California National Primate Research Center, we have developed a program to assess biobehavioral organization in infant rhesus monkeys. Our protocol includes a) collecting behavioral data in several situations designed to assess memory, responsiveness to mild challenges, and willingness to interact with novel objects; b) genotyping for polymorphisms in the promoter regions of two neuropsychiatric genes, the serotonin transporter and monoamine oxidase-A; c) assessing regulation of the hypothalamic-pituitary-adrenal system; and d) measuring routine hematologic parameters. Data from this resource are available to all CNPRC service and scientific staff via a web interface, to use for scientific and colony management purposes. In the current application, we propose the following specific aims: to continue performing our BioBehavioral Assessment on approximately 300 infant rhesus monkeys per year and to make these data available to qualified scientific and management staff through our web page as soon as the processing of the data is complete each year; to continue our ongoing efforts to identify the attributes of former participants in our BBA program that are at risk for poor adaptation to a captive environment as indexed by measures of chronic illness, abnormal behaviors, poor reproduction, and aberrant social function; to use existing statistical methods on our BBA data to establish individual profiles associated with poor outcomes as aids to colony management personnel to prevent health, behavioral, reproductive, and social problems; to continue to develop standardized tests that are shorter, simpler, and easier to administer than our current procedure, yet meet the same standards of reliability and predictive validity for our outcome measures. PUBLIC HEALTH RELEVANCE (provided by applicant): This project will result in improved nonhuman primate models for health-related research, and will provide a database that will be uniquely able to contribute to the development of primate models of personalized medicine.

描述（由申请人提供）：三十年来对啮齿动物、非人类灵长类动物和人类的心理生物学研究已经证明了气质、情绪、行为和生理反应性以及个性方面存在个体差异，我们将其称为生物行为组织。这些特征影响个体适应环境的方式，有证据表明动物适应的质量与心理和身体健康指数相关。在加州国家灵长类动物研究中心，我们开发了一个项目来评估幼年恒河猴的生物行为组织。我们的协议包括a）收集多种情况下的行为数据，旨在评估记忆力、对轻微挑战的反应能力以及与新物体互动的意愿； b) 两个神经精神基因（血清素转运蛋白和单胺氧化酶-A）启动子区域多态性的基因分型； c) 评估下丘脑-垂体-肾上腺系统的调节； d) 测量常规血液学参数。所有 CNPRC 服务和科学人员均可通过网络界面获取该资源中的数据，用于科学和群体管理目的。在当前的申请中，我们提出以下具体目标：每年继续对大约 300 只幼年恒河猴进行生物行为评估，并在每年数据处理完成后立即通过我们的网页向合格的科学和管理人员提供这些数据；继续我们不断的努力，以确定 BBA 计划的前参与者的属性，这些属性面临着对圈养环境适应不良的风险，如索引所示 慢性病、行为异常、繁殖不良和社会功能异常的措施；使用现有的 BBA 数据统计方法来建立与不良结果相关的个人档案，以帮助群体管理人员预防健康、行为、生殖和社会问题；继续开发比我们当前程序更短、更简单、更容易管理的标准化测试，同时满足我们结果测量的相同可靠性和预测有效性标准。 公共健康相关性（由申请人提供）：该项目将改进用于健康相关研究的非人类灵长类动物模型，并将提供一个能够独特地为个性化医疗灵长类动物模型的开发做出贡献的数据库。