SOCIAL HOUSING AND SIV DISEASE

社会住房和 SIV 疾病

• 批准号: 8358127
• 负责人: KATE CANFIELD BAKER
• 金额: $ 5.78万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358127
• 关键词: Adult; Animal Care and Use Committees; Animals; Behavioral; Biomedical Research; Clinical Data; Code; Data; Data Collection; Development; Disease; Disease Progression; Funding; Grant; Housing; Individual; Infection; Macaca mulatta; Measures; Methods; National Center for Research Resources; Physiological; Physiology; Primates; Principal Investigator; Protocols documentation; Quality of life; Research; Research Infrastructure; Research Subjects; Resources; SIV; Schedule; Source; Study Subject; United States National Institutes of Health; Vaccines; Videotape; Virus Diseases; cost; meetings; member; nonhuman primate; prophylactic; psychologic; sex; social

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Introduction. Nonhuman primates used in biomedical research can be provided the best quality of life if their management takes their disease status into consideration. For example, it is important to understand how to best meet the social needs of primates throughout the progression of the Simian Immunodeficiency Virus disease. This study aims to 1) characterize the changes in psychological wellbeing associated with Simian Immunodeficiency Virus disease progression, 2) determine the correspondence between measures of wellbeing and disease-related changes in physiology, and 3) identify any threshold behavioral or physiological values that should be used to trigger either increased scrutiny of compatibility or alterations in the social setting of research subjects. Methods. Subjects include adult, Indian-origin rhesus macaques assigned to research protocols involving SIV infection and anticipated development of SIV disease (i.e. not subject to vaccines, other prophylactic measures, or experimental treatments). The total number of subjects studied will be 32 of each sex. Using behavioral, physiological, immunological and clinical data, changes within individuals are assessed. In addition, effects of pair- versus single housing is being compared. Videotaped data collection begins prior to social introduction and SIV inoculation in order to document baseline profiles in single housing, and is repeated after introduction into pair housing and prior to infection. Within pairs, both members are inoculated on the same day. After inoculation, data are collected intensively for the first month. After the first month, a steady scheduling of less intensive data collection is followed until the endpoints approved by the Animal Care and Use Committee are reached. Results/Discussion. Twelve animals reached study endpoints and data coding has been initiated.

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