SOCIAL HOUSING AND SIV DISEASE

社会住房和 SIV 疾病

• 批准号: 8358127
• 负责人: KATE CANFIELD BAKER
• 金额: $ 5.78万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358127
• 关键词: Adult; Animal Care and Use Committees; Animals; Behavioral; Biomedical Research; Clinical Data; Code; Data; Data Collection; Development; Disease; Disease Progression; Funding; Grant; Housing; Individual; Infection; Macaca mulatta; Measures; Methods; National Center for Research Resources; Physiological; Physiology; Primates; Principal Investigator; Protocols documentation; Quality of life; Research; Research Infrastructure; Research Subjects; Resources; SIV; Schedule; Source; Study Subject; United States National Institutes of Health; Vaccines; Videotape; Virus Diseases; cost; meetings; member; nonhuman primate; prophylactic; psychologic; sex; social

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Introduction. Nonhuman primates used in biomedical research can be provided the best quality of life if their management takes their disease status into consideration. For example, it is important to understand how to best meet the social needs of primates throughout the progression of the Simian Immunodeficiency Virus disease. This study aims to 1) characterize the changes in psychological wellbeing associated with Simian Immunodeficiency Virus disease progression, 2) determine the correspondence between measures of wellbeing and disease-related changes in physiology, and 3) identify any threshold behavioral or physiological values that should be used to trigger either increased scrutiny of compatibility or alterations in the social setting of research subjects. Methods. Subjects include adult, Indian-origin rhesus macaques assigned to research protocols involving SIV infection and anticipated development of SIV disease (i.e. not subject to vaccines, other prophylactic measures, or experimental treatments). The total number of subjects studied will be 32 of each sex. Using behavioral, physiological, immunological and clinical data, changes within individuals are assessed. In addition, effects of pair- versus single housing is being compared. Videotaped data collection begins prior to social introduction and SIV inoculation in order to document baseline profiles in single housing, and is repeated after introduction into pair housing and prior to infection. Within pairs, both members are inoculated on the same day. After inoculation, data are collected intensively for the first month. After the first month, a steady scheduling of less intensive data collection is followed until the endpoints approved by the Animal Care and Use Committee are reached. Results/Discussion. Twelve animals reached study endpoints and data coding has been initiated.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 介绍。 如果考虑到生物医学研究中使用的非人类灵长类动物，则可以为他们的管理疾病状况提供最佳的生活质量。 例如，重要的是要了解如何在整个猿猴免疫缺陷病毒疾病的整个过程中最好地满足灵长类动物的社会需求。 这项研究的目的是1）表征与邻生免疫缺陷病毒疾病进展相关的心理健康的变化，2）确定福祉和与疾病相关的生理学变化之间的对应关系，以及3）确定应使用的任何阈值行为或生理价值，以触发研究主题的兼容性或改变的研究。 方法。 受试者包括涉及SIV感染和SIV疾病的预期发展的研究方案的成人，印度恒河猴（即不接受疫苗，其他预防措施或实验治疗）。 所研究的受试者总数为每个性别的32。 使用行为，生理，免疫学和临床数据，评估了个体内部的变化。 此外，正在比较配对与单个外壳的效果。 录像数据收集在社交介绍和SIV接种之前开始，以记录单个住房中的基线概况，并在引入配对外壳和感染之前重复。 在成对内，两个成员在同一天接种。 接种后，第一个月收集数据。 在第一个月之后，遵循稳定的数据收集时间表，直到达成动物护理和使用委员会批准的终点为止。 结果/讨论。 十二只动物达到了研究终点，并且已经启动了数据编码。