EFFECTS OF STRESSFUL EVENTS IN SINGLY- VS PAIR-HOUSED ADULT MALE MACAQUES

压力事件对单养与配对成年雄性猕猴的影响

• 批准号: 7958674
• 负责人: KATE CANFIELD BAKER
• 金额: $ 5.75万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958674
• 关键词: Adult; Affect; Anesthesia procedures; Animals; Behavior; Behavioral; Buffers; Computer Retrieval of Information on Scientific Projects Database; Data; Data Collection; Devices; Enrollment; Frequencies; Funding; Grant; Housing; Implant; Individual; Institution; Laboratories; Long-Term Effects; Macaca; Macaca mulatta; Measures; Methods; Monkeys; Outcome; Personal Satisfaction; Phase; Physiological; Primates; Research; Research Personnel; Resources; Sampling; Source; Stressful Event; Telemetry; Time; United States National Institutes of Health; male; nonhuman primate; restraint; social; species typical behavior

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Social housing for captive nonhuman primates has been shown to reduce the frequency of abnormal behavior and to increase species-typical behavior. In addition, previous research at the Tulane National Primate Research Center using male rhesus macaques implanted with telemetry devices has shown that physiological parameters correspond to the behavioral parameters of successful social introductions. The purpose of this ongoing study is to examine the long-term effects of social introduction by measuring, via physiological and behavioral means, the potential of social housing to act as a buffer to stressful events. Methods: The monkeys were first implanted with telemetry devices. They were initially housed singly, and during this phase, both behavioral and physiological data were collected during 30-minute focal animal samples. During this time, potentially stressful events that occurred as part of the monkeys' daily routine were documented with physiological and behavioral parameters. The monkeys were then paired, and once they were in settled social pairs, the data collection as described above was repeated. Twelve M. mulatta were enrolled on the study. Behavioral and physiological data have been collected on all subjects. Results/Discussion: When visually exposed to the restraint and anesthesia of another monkey in the room, monkeys that are pair housed show statistically significant reductions in rates of abnormal behavior. No statistically significant differences were seen when dominant and subordinate individuals were compared. The results of this study indicate that social buffering during stressful events can be considered an additional benefit to the well-being of socially-housed laboratory nonhuman primates. This is important in research because both physiological and behavioral parameters can affect the outcome of data during a study.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 简介：对圈养的非人灵长类动物进行社会性圈养，已被证明可以减少异常行为的频率，并增加物种典型行为。 此外，杜兰国家灵长类动物研究中心先前使用植入遥测装置的雄性恒河猴进行的研究表明，生理参数与成功社交介绍的行为参数相对应。 这项正在进行的研究的目的是通过测量，通过生理和行为的手段，社会住房作为缓冲压力事件的潜力，以检查社会介绍的长期影响。 方法：首先在猴子体内植入遥测装置。 它们最初单独圈养，在此阶段，在30分钟的局灶性动物样本期间收集行为和生理数据。 在此期间，作为猴子日常生活的一部分发生的潜在压力事件被记录了生理和行为参数。 然后将猴子配对，一旦它们在固定的社会配对中，重复如上所述的数据收集。 十二米穆拉塔人参加了这项研究。 收集了所有受试者的行为和生理数据。 结果/讨论：当视觉暴露于房间中另一只猴子的约束和麻醉时，成对圈养的猴子显示异常行为率在统计学上显著降低。 没有统计学上的显着差异时，占主导地位的和从属的个人进行了比较。 这项研究的结果表明，在压力事件的社会缓冲可以被认为是一个额外的好处，社会圈养的实验室非人灵长类动物的福祉。 这在研究中很重要，因为生理和行为参数都会影响研究期间的数据结果。