SOCIAL HOUSING AND SIV DISEASE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 导言。如果非人类灵长类动物的管理考虑到它们的疾病状况，那么生物医学研究中使用的非人类灵长类动物可以提供最佳的生活质量。例如，在猴艾滋病的整个发展过程中，了解如何最好地满足灵长类动物的社会需求是很重要的。这项研究旨在1)描述与猴免疫缺陷病毒疾病进展相关的心理幸福感的变化，2)确定幸福感衡量标准与疾病相关生理变化之间的对应关系，3)确定任何阈值行为或生理值，这些值应该被用来触发对研究对象的兼容性或社会环境变化的更多审查。方法：研究方法。受试者包括成年印度猕猴，这些猕猴被分配到涉及SIV感染和SIV疾病预期发展的研究方案中(即不受疫苗、其他预防措施或实验性治疗的影响)。研究对象总数为男女各32人。使用行为、生理、免疫学和临床数据，评估个体内的变化。此外，还在比较成对住房和单一住房的效果。数据收集在社会介绍和SIV接种之前开始，以记录单一住房中的基线概况，并在引入成对住房后和感染之前重复。在配对的情况下，两个成员在同一天接种。接种后，第一个月密集收集数据。在第一个月之后，按照不太密集的数据收集的稳定计划进行，直到达到动物保护和使用委员会批准的终点。结果/讨论。已经开始收集24名受试者的数据，到目前为止，所有受试者都已感染，但没有一人达到研究终点。在一个人被安乐死后，将对每个人进行数据分析。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction. Nonhuman primates used in biomedical research can be provided the best quality of life if their management takes their disease status into consideration. For example, it is important to understand how to best meet the social needs of primates throughout the progression of simian AIDS. This study aims to 1) characterize the changes in psychological wellbeing associated with simian immunodeficiency virus disease progression, 2) determine the correspondence between measures of wellbeing and disease-related changes in physiology, and 3) identify any threshold behavioral or physiological values that should be used to trigger either increased scrutiny of compatibility or alterations in the social setting of research subjects. Methods. Subjects include adult, Indian-origin rhesus macaques assigned to research protocols involving SIV infection and anticipated development of SIV disease (i.e. not subject to vaccines, other prophylactic measures, or experimental treatments). The total number of subjects studied will be 32 of each sex. Using behavioral, physiological, immunological and clinical data, changes within individuals are assessed. In addition, effects of pair- versus single housing is being compared . Data collection begins prior to social introduction and SIV inoculation in order to document baseline profiles in single housing, and is repeated after introduction into pair housing and prior to infection. Within pairs, both members are inoculated on the same day. After inoculation, data are collected intensively for the first month. After the first month, a steady scheduling of less intensive data collection is followed until the endpoints approved by the Animal Care and Use Committee are reached. Results/Discussion. Data collection has been initiated for 24 subjects, all of whom have been infected to date but none of whom have reached study endpoints. Data analysis for each individual will commense after an individual is euthanized.