SOCIAL HOUSING AND SIV DISEASE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 导论. 如果对非人灵长类动物的管理考虑到它们的疾病状况，那么可以为生物医学研究中使用的非人灵长类动物提供最好的生活质量。 例如，在猿类艾滋病的整个发展过程中，了解如何最好地满足灵长类动物的社会需求是很重要的。 本研究的目的是：1）描述与猴免疫缺陷病毒疾病进展相关的心理健康变化，2）确定健康指标与疾病相关生理变化之间的对应关系，3）确定任何阈值行为或生理值，这些值应用于触发对研究对象的兼容性或社会环境变化的增加审查。 方法. 受试者包括被分配到涉及SIV感染和预期SIV疾病发展的研究方案（即不接受疫苗、其他预防措施或实验性治疗）的成年印度恒河猴。 研究的受试者总数为每种性别32例。 使用行为、生理、免疫和临床数据，评估个体内的变化。 此外，正在比较成对与单个外壳的效果。 数据收集在社会引入和SIV接种之前开始，以记录单个圈养中的基线概况，并在引入成对圈养后和感染前重复。 在配对中，两个成员在同一天接种。 接种后，第一个月集中收集数据。 第一个月后，遵循不太密集的数据收集的稳定时间表，直到达到动物护理和使用委员会批准的终点。 结果/讨论。 已开始收集24例受试者的数据，迄今为止所有受试者均已感染，但均未达到研究终点。 对每个个体的数据分析将在个体被安乐死后开始。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction. Nonhuman primates used in biomedical research can be provided the best quality of life if their management takes their disease status into consideration. For example, it is important to understand how to best meet the social needs of primates throughout the progression of simian AIDS. This study aims to 1) characterize the changes in psychological wellbeing associated with simian immunodeficiency virus disease progression, 2) determine the correspondence between measures of wellbeing and disease-related changes in physiology, and 3) identify any threshold behavioral or physiological values that should be used to trigger either increased scrutiny of compatibility or alterations in the social setting of research subjects. Methods. Subjects include adult, Indian-origin rhesus macaques assigned to research protocols involving SIV infection and anticipated development of SIV disease (i.e. not subject to vaccines, other prophylactic measures, or experimental treatments). The total number of subjects studied will be 32 of each sex. Using behavioral, physiological, immunological and clinical data, changes within individuals are assessed. In addition, effects of pair- versus single housing is being compared . Data collection begins prior to social introduction and SIV inoculation in order to document baseline profiles in single housing, and is repeated after introduction into pair housing and prior to infection. Within pairs, both members are inoculated on the same day. After inoculation, data are collected intensively for the first month. After the first month, a steady scheduling of less intensive data collection is followed until the endpoints approved by the Animal Care and Use Committee are reached. Results/Discussion. Data collection has been initiated for 24 subjects, all of whom have been infected to date but none of whom have reached study endpoints. Data analysis for each individual will commense after an individual is euthanized.