EFFECTS OF STRESSFUL EVENTS IN SINGLY- VS PAIR-HOUSED ADULT MALE MACAQUES

压力事件对单养与配对成年雄性猕猴的影响

• 批准号: 8358090
• 负责人: KATE CANFIELD BAKER
• 金额: $ 3.72万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358090
• 关键词: Adult; Anesthesia procedures; Anxiety; Behavior; Buffers; Frequencies; Funding; Grant; Housing; Individual; Laboratories; Macaca; Macaca mulatta; Methods; Monkeys; National Center for Research Resources; Primates; Principal Investigator; Procedures; Reaction; Research; Research Infrastructure; Resources; Source; Stressful Event; Testing; United States National Institutes of Health; Videotape; cost; male; response; restraint; social; stressor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The purpose of this study was to test whether long-term pair housing of male rhesus macaques ameliorated negative responses to stressful events that can occur in the course of routine husbandry or research procedures. Methods: Twelve singly housed individuals were videotaped during two potentially stressful events before and after social introduction into pairs. During each stressor, abnormal behavior and anxiety-related behavior were quantified from videotape. Results/Conclusion:When visually exposed to the restraint and anesthesia of other monkeys, subjects showed significantly reduced frequencies of abnormal behavior when pair-housed in comparison to their reactions when housed singly. Noisy and disruptive conversation between technicians standing immediately in front of the subjects' cage did not elicit the same reduction in abnormal behavior. Neither test showed a significant difference across housing settings for anxiety-related behaviors. These findings suggest that pair housing buffers adult male rhesus macaques against common stressors in the laboratory setting.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 本研究的目的是测试是否长期对住房的雄性恒河猴改善负面反应的压力事件，可能会发生在日常饲养或研究程序的过程中。研究方法： 12个单独居住的个人在两个潜在的压力事件之前和之后的社会介绍对录像。在每一个压力源，异常行为和焦虑相关的行为进行量化的录像带。结果/结论：当视觉上暴露于其他猴子的约束和麻醉，受试者表现出显着减少的频率异常行为时，对圈养相比，他们的反应时，单独圈养。站在受试者笼子前的技术人员之间嘈杂和破坏性的谈话并没有引起异常行为的减少。这两项测试都没有显示出在焦虑相关行为的住房设置的显着差异。 这些研究结果表明，对住房缓冲成年雄性恒河猴对常见的压力在实验室设置。