EFFECTS OF STRESSFUL EVENTS IN SINGLY- VS PAIR-HOUSED ADULT MALE MACAQUES

压力事件对单养与配对成年雄性猕猴的影响

• 批准号: 8358090
• 负责人: KATE CANFIELD BAKER
• 金额: $ 3.72万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358090
• 关键词: Adult; Anesthesia procedures; Anxiety; Behavior; Buffers; Frequencies; Funding; Grant; Housing; Individual; Laboratories; Macaca; Macaca mulatta; Methods; Monkeys; National Center for Research Resources; Primates; Principal Investigator; Procedures; Reaction; Research; Research Infrastructure; Resources; Source; Stressful Event; Testing; United States National Institutes of Health; Videotape; cost; male; response; restraint; social; stressor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The purpose of this study was to test whether long-term pair housing of male rhesus macaques ameliorated negative responses to stressful events that can occur in the course of routine husbandry or research procedures. Methods: Twelve singly housed individuals were videotaped during two potentially stressful events before and after social introduction into pairs. During each stressor, abnormal behavior and anxiety-related behavior were quantified from videotape. Results/Conclusion:When visually exposed to the restraint and anesthesia of other monkeys, subjects showed significantly reduced frequencies of abnormal behavior when pair-housed in comparison to their reactions when housed singly. Noisy and disruptive conversation between technicians standing immediately in front of the subjects' cage did not elicit the same reduction in abnormal behavior. Neither test showed a significant difference across housing settings for anxiety-related behaviors. These findings suggest that pair housing buffers adult male rhesus macaques against common stressors in the laboratory setting.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 这项研究的目的是测试雄性猕猴长期的配对住所是否可以改善在日常饲养或研究过程中可能发生的应激事件的负面反应。方法：对12名独居者在两次潜在的应激事件中进行录像带，这些事件发生在社交介绍成对前后。在每个应激源期间，从录像带中量化异常行为和与焦虑相关的行为。结果/结论：当视觉上暴露在其他猴子的束缚和麻醉下时，与单独饲养时相比，配对饲养的受试者异常行为的发生率显著降低。站在受试者笼子前的技术人员之间嘈杂和破坏性的交谈并没有导致异常行为的同样减少。这两项测试都没有显示出在不同的住房环境中焦虑相关行为的显著差异。这些发现表明，在实验室环境中，配对住房可以缓冲成年雄性猕猴免受常见压力的影响。