ANDROGEN EXPOSURE AND ACTIONS IN PRE- TO PERIPUBERTAL MONKEYS

青春期前猴子的雄激素暴露和作用

• 批准号: 8173202
• 负责人: JUDY L CAMERON
• 金额: $ 4.76万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173202
• 关键词: Age at Menarche; American; Androgens; Anovulation; Antral; Chronic; Computer Retrieval of Information on Scientific Projects Database; Disease; Etiology; Exposure to; Feedback; Female; Female Adolescents; Frequencies; Funding; Goals; Gonadotropin Hormone Releasing Hormone; Grant; Hyperandrogenism; Infertility; Institution; Insulin Resistance; Knowledge; Luteinizing Hormone; Macaca mulatta; Menarche; Menstrual cycle; Modeling; Monkeys; Neurosecretory Systems; Oligonucleotides; Ovarian; Ovary; Physiologic pulse; Pituitary Gland; Prevention; Primates; Progesterone; Puberty; Research; Research Personnel; Resources; Source; Steroids; Symptoms; Syndrome; Testosterone; United States National Institutes of Health; Woman; indexing

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Polycystic Ovarian Syndrome (PCOS) is a common disorder of hyperandrogenism and oligo/anovulation, causing infertility in 4-8% of American women. The etiology of PCOS remains controversial. Though insulin resistance is considered one cause of PCOS, correlative evidence suggests that exposure to increased levels of androgens (from the ovaries) before and during puberty may be a primary cause of many PCOS symptoms. The goal of this project is to determine whether chronic exposure to elevated levels of testosterone (T), found in adolescent girls predisposed to PCOS, will cause changes in the neuroendocrine-ovarian axis in peri-pubertal female rhesus macaques that are reminiscent of PCOS. Ovarian parameters include age at menarche, occurrence of normal menstrual cycles, and numbers/sizes of antral follicles in the ovaries. Neuroendocrine indices will include the frequency and amplitude of circulating luteinizing hormone (LH) pulses secreted by the pituitary gland, sensitivity of LH secretion to exogenous gonadotropin-releasing hormone (GnRH), and steroid (exogenous progesterone) feedback inhibition of LH secretion after menarche. This project will greatly increase our knowledge of the effects of elevated androgen exposure in female adolescents, and possibly develop a primate model for better understanding of the causes, prevention and treatment of PCOS in women.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 多囊卵巢综合症 (PCOS) 是一种常见的雄激素过多症和排卵少/无排卵疾病，导致 4-8% 的美国女性不孕。 PCOS 的病因仍存在争议。尽管胰岛素抵抗被认为是 PCOS 的原因之一，但相关证据表明，在青春期之前和期间接触（来自卵巢）雄激素水平升高可能是许多 PCOS 症状的主要原因。该项目的目标是确定长期暴露于易患 PCOS 的青春期女孩体内睾酮 (T) 水平升高是否会导致青春期雌性恒河猴的神经内分泌-卵巢轴发生变化，从而让人联想到 PCOS。卵巢参数包括初潮年龄、正常月经周期的发生情况以及卵巢窦卵泡的数量/大小。神经内分泌指标包括垂体分泌的循环黄体生成素 (LH) 脉冲的频率和幅度、LH 分泌对外源性促性腺激素释放激素 (GnRH) 的敏感性以及初潮后类固醇（外源性黄体酮）对 LH 分泌的反馈抑制。该项目将极大地增加我们对雄激素暴露对女性青少年的影响的了解，并可能开发灵长类动物模型，以更好地了解女性多囊卵巢综合症的原因、预防和治疗。