ANDROGEN EXPOSURE AND ACTIONS IN PRE- TO PERIPUBERTAL MONKEYS

青春期前猴子的雄激素暴露和作用

• 批准号: 8173202
• 负责人: JUDY L CAMERON
• 金额: $ 4.76万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173202
• 关键词: Age at Menarche; American; Androgens; Anovulation; Antral; Chronic; Computer Retrieval of Information on Scientific Projects Database; Disease; Etiology; Exposure to; Feedback; Female; Female Adolescents; Frequencies; Funding; Goals; Gonadotropin Hormone Releasing Hormone; Grant; Hyperandrogenism; Infertility; Institution; Insulin Resistance; Knowledge; Luteinizing Hormone; Macaca mulatta; Menarche; Menstrual cycle; Modeling; Monkeys; Neurosecretory Systems; Oligonucleotides; Ovarian; Ovary; Physiologic pulse; Pituitary Gland; Prevention; Primates; Progesterone; Puberty; Research; Research Personnel; Resources; Source; Steroids; Symptoms; Syndrome; Testosterone; United States National Institutes of Health; Woman; indexing

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Polycystic Ovarian Syndrome (PCOS) is a common disorder of hyperandrogenism and oligo/anovulation, causing infertility in 4-8% of American women. The etiology of PCOS remains controversial. Though insulin resistance is considered one cause of PCOS, correlative evidence suggests that exposure to increased levels of androgens (from the ovaries) before and during puberty may be a primary cause of many PCOS symptoms. The goal of this project is to determine whether chronic exposure to elevated levels of testosterone (T), found in adolescent girls predisposed to PCOS, will cause changes in the neuroendocrine-ovarian axis in peri-pubertal female rhesus macaques that are reminiscent of PCOS. Ovarian parameters include age at menarche, occurrence of normal menstrual cycles, and numbers/sizes of antral follicles in the ovaries. Neuroendocrine indices will include the frequency and amplitude of circulating luteinizing hormone (LH) pulses secreted by the pituitary gland, sensitivity of LH secretion to exogenous gonadotropin-releasing hormone (GnRH), and steroid (exogenous progesterone) feedback inhibition of LH secretion after menarche. This project will greatly increase our knowledge of the effects of elevated androgen exposure in female adolescents, and possibly develop a primate model for better understanding of the causes, prevention and treatment of PCOS in women.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 多囊卵巢综合征(PCOS)是一种常见的高雄激素血症和少/无排卵障碍，导致4%-8%的美国女性不孕。多囊卵巢综合征的病因仍然存在争议。虽然胰岛素抵抗被认为是多囊卵巢综合征的原因之一，但相关证据表明，青春期前和青春期期间暴露于雄激素水平增加(来自卵巢)可能是许多多囊卵巢综合征症状的主要原因。该项目的目标是确定长期暴露于高水平的睾酮(T)是否会导致青春期雌性恒河猴神经内分泌轴的变化，这让人想起多囊卵巢综合征。卵巢参数包括月经初潮年龄、正常月经周期的发生情况以及卵巢中有腔卵泡的数量/大小。神经内分泌指标将包括脑下垂体分泌的循环黄体生成素(LH)脉冲的频率和幅度，黄体生成素分泌对外源性促性腺激素释放激素(GnRH)的敏感性，以及月经初潮后类固醇(外源性黄体酮)对黄体生成素分泌的反馈抑制。该项目将大大增加我们对女性青少年雄激素水平升高的影响的了解，并可能开发一种灵长类动物模型，以更好地了解女性多囊卵巢综合征的原因、预防和治疗。