ALTERED NUCLEAR TRANSFER
ALTERED NUCLEAR TRANSFER
批准号:
8357769
负责人:
SHOUKHRAT M MITALIPOV
金额:
$14.55万
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-05-01 至 2012-04-30
关键词:
AffectBypassCDX2 geneCell LineageDown-RegulationEmbryoFundingGoalsGrantNational Center for Research ResourcesOocytesPluripotent Stem CellsPrimatesPrincipal InvestigatorProcessProductionResearchResearch InfrastructureResourcesSourceUnited States National Institutes of Healthcosteggembryonic stem cellnuclear transfersomatic cell nuclear transfer
中文摘要
这个子项目是利用这些资源的众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
The goal of this project is to utilize altered somatic cell nuclear transfer into primate eggs with the hope of yielding pluripotent stem cells while bypassing the production/destruction of viable embryos in the process. We showed that the trophectodermal lineage in primate embryos can be abrogated by downregulation of CDX2 in unfertilized oocytes. The pluripotent inner cell lineage was not affected and produced functional ES cells.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Reconstructing Somatic Chromosomes
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批准号:10772559
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项目类别:
-
资助金额:$65.99万
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财政年份:2023
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负责人:SHOUKHRAT M MITALIPOV
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依托单位:
Horizontal mtDNA Exchange
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批准号:10356794
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项目类别:
-
资助金额:$55.93万
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财政年份:2019
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负责人:SHOUKHRAT M MITALIPOV
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依托单位:
Horizontal mtDNA Exchange
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批准号:9902293
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项目类别:
-
资助金额:$55.93万
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财政年份:2019
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负责人:SHOUKHRAT M MITALIPOV
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依托单位:
Horizontal mtDNA Exchange
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批准号:10584513
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项目类别:
-
资助金额:$55.93万
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财政年份:2019
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负责人:SHOUKHRAT M MITALIPOV
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依托单位:
Mitochondrial Aging and Reprogramming
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批准号:9142455
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项目类别:
-
资助金额:$52.31万
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财政年份:2015
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负责人:SHOUKHRAT M MITALIPOV
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依托单位:
CORRECTING MITOCHONDIRAL GENE MUTATIONS IN HUMAN OOCYTES
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批准号:8357848
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项目类别:
-
资助金额:$5.82万
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财政年份:2011
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负责人:SHOUKHRAT M MITALIPOV
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依托单位:
HISTOCOMPATIBLE PRIMATE EMBYONIC STEM CELLS (ESCS)
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批准号:8357828
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项目类别:
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资助金额:$7.28万
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财政年份:2011
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负责人:SHOUKHRAT M MITALIPOV
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依托单位:
DERIVING OOCYTES FROM EMBRYONIC STEM CELLS (ESCS)
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批准号:8357829
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项目类别:
-
资助金额:$4.36万
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财政年份:2011
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负责人:SHOUKHRAT M MITALIPOV
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依托单位:
MITOCHONDRIAL GENE THEREAPY IN A MACAQUE MODEL
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批准号:8357849
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项目类别:
-
资助金额:$7.28万
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财政年份:2011
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负责人:SHOUKHRAT M MITALIPOV
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依托单位:
Altered Nuclear Transfer
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批准号:8013894
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项目类别:
-
资助金额:$53.81万
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财政年份:2010
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负责人:SHOUKHRAT M MITALIPOV
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依托单位:
PRIMATE PLURIPOTENT CELLS FOR AUTOLOGOUS TRANSPLANTATION
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批准号:8173333
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项目类别:
-
资助金额:$7.61万
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财政年份:2010
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负责人:SHOUKHRAT M MITALIPOV
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依托单位:
Mitochondrial Gene Therapy
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批准号:8447582
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项目类别:
-
资助金额:$57.42万
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财政年份:2010
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负责人:SHOUKHRAT M MITALIPOV
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依托单位:
Altered Nuclear Transfer
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批准号:8431435
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项目类别:
-
资助金额:$52.91万
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财政年份:2010
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负责人:SHOUKHRAT M MITALIPOV
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依托单位:
GENETIC ANALYSIS OF GERM CELL FORMATION
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批准号:8173332
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项目类别:
-
资助金额:$7.61万
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财政年份:2010
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负责人:SHOUKHRAT M MITALIPOV
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依托单位:
Altered Nuclear Transfer
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批准号:8212330
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项目类别:
-
资助金额:$54.36万
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财政年份:2010
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负责人:SHOUKHRAT M MITALIPOV
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依托单位:
Mitochondrial Gene Therapy
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批准号:8056813
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项目类别:
-
资助金额:$61.86万
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财政年份:2010
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负责人:SHOUKHRAT M MITALIPOV
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依托单位:
DERIVING OOCYTES FROM ESCS
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批准号:8173327
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项目类别:
-
资助金额:$4.76万
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财政年份:2010
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负责人:SHOUKHRAT M MITALIPOV
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依托单位:
Mitochondrial Gene Therapy
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批准号:8241150
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项目类别:
-
资助金额:$61.5万
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财政年份:2010
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负责人:SHOUKHRAT M MITALIPOV
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依托单位:
Mitochondrial Gene Therapy
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批准号:8644818
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项目类别:
-
资助金额:$53.0万
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财政年份:2010
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负责人:SHOUKHRAT M MITALIPOV
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依托单位:
Mitochondrial Gene Therapy
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批准号:7898222
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项目类别:
-
资助金额:$64.35万
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财政年份:2010
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负责人:SHOUKHRAT M MITALIPOV
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依托单位:
国内基金
海外基金
展向局部自由流湍流下边界层bypass转捩的二次失稳机理的研究
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批准号:11202147
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项目类别:青年科学基金项目
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资助金额:26.0万元
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批准年份:2012
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负责人:张永明
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依托单位:
边界层中Bypass转捩机理的研究
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批准号:11102131
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项目类别:青年科学基金项目
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资助金额:26.0万元
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批准年份:2011
-
负责人:董明
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依托单位: