MOVEMENT DISORDERS AND EYE MOVEMENTS

运动障碍和眼球运动

• 批准号: 8358208
• 负责人: Michele A Basso
• 金额: $ 26.77万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358208
• 关键词: Animals; Basal Ganglia; Behavior; Brain region; Clinical; Cognition; Cognitive; Disease; Eye Movements; Funding; Grant; Huntington Disease; Lead; Learning; Light; Memory; Motor; Movement; National Center for Research Resources; Neurons; Ocular Motility Disorders; Parkinson Disease; Pathway interactions; Play; Primates; Principal Investigator; Process; Research; Research Infrastructure; Resources; Role; Saccades; Services; Source; Structure; System; Techniques; United States National Institutes of Health; Vision; Wisconsin; cost; design; expectation; human subject; relating to nervous system; superior colliculus Corpora quadrigemina

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: To understand how higher order processes or cognition contribute to the control of voluntary movement. Because the execution of voluntary actions usually involves processes such as target selection, learning, memory, planning and expectation, motor systems are well suited for study of these processes. We investigate neuronal processes leading up to the execution of movements of the eyes, in particular, those eye movements that lead to rapid changes in the line of sight - saccades. We have a multi-technique approach to the study of these processes. First, we record electrical activity of single neurons while the subjects perform eye movement tasks designed to tap into cognitive processes. Second, we activate or inactivate particular regions of the brain to produce behaviors or interfere with ongoing behaviors and neural processing. Finally, because damage to certain brain regions produces profound clinical disorders such as Parkinson's disease and Huntington's disease, we study eye movements of both healthy and diseased human subjects to further our understanding of the role these structures play in both cognition and in producing the debilitating effects of these disorders. This research used WNPRC Animal Services. PUBLICATION: Shires J, Joshi S, Basso MA. Shedding new light on the role of the basal ganglia  superior colliculus pathway in eye movements. Curr Opin Neurobiol. 2010 Dec;20(6):717-25. PMID: 20829033, PMCID: PMC3008502.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 目的：了解更高阶的过程或认知是如何对 对自愿行动的控制。 因为志愿行动的执行通常涉及诸如目标等过程 选择、学习、记忆、计划和期望，马达系统非常适合 来研究这些过程。我们研究了神经过程导致 眼睛运动的执行，特别是那些导致 视线的快速变化--扫视。我们有一个多技术的方法来 对这些过程的研究。首先，我们记录单个神经元的电活动 当受试者执行旨在利用认知能力的眼动任务时 流程。第二，我们激活或停用大脑的特定区域以 产生行为或干扰正在进行的行为和神经处理。最后， 因为某些大脑区域的损伤会导致严重的临床疾病，如 作为帕金森氏病和亨廷顿病，我们研究了两者的眼球运动 健康和患病的人类受试者进一步了解这些作用 结构既在认知中发挥作用，也在产生这些结构的衰弱效应方面发挥作用 精神错乱。 这项研究使用了WNPRC动物服务中心。 出版物： 书名/作者/作者：Joshi J/J/Joshi J.揭示了基底节的作用 眼球运动中的上丘通路。Curr Opin Neurobiol。2010年 12月20日(6)：717-25。PMID：20829033，PMC3008502。