Multi-Center Blinded Analysis of XMRV/MLV in Chronic Fatigue Syndrome

东北生物防御中心（NBC）是一个由28个学术和研究领域的350多名调查人员组成的联盟。 机构（其中许多在更大的纽约都会区彼此靠近），和13个美国 政府和国际组织。在过去的五年里，NBC的调查人员 表明他们致力于跨学科和机构界限合作， 研究和培训计划的重点是生物防御和新出现的传染病， 应急准备。生产力的证据包括>160篇出版物，15项发明公开，13项 专利申请和5项产品开发许可证。这次更新将包括42名调查员， 32个研究项目分为6个科学主题领域：被动免疫治疗（主席：Arturo Casadevall，Einstein）;疫苗（主席：John Rose，耶鲁大学）;诊断和病原体发现（主席：Ian Lipkin，哥伦比亚）;治疗学（主席：Charles Rice，Rockefeller和霍华德Shuman，哥伦比亚）;先天 免疫学（主席：纽约大学的大卫·利维（David Levy）和西奈半岛的阿道夫·加西亚-萨斯特雷（Adolfo Garcia-Sastre））和微生物发病机制（主席： Jorge E. Galan，Yale，and Jorge Benach，Stony Book）.生物技术和制药合作者是 在诊断和病原体发现（Agilent，Akonni，Cepheid，Xynostics，454 Life 科学），治疗学（Prosetta，Snowdon）和被动免疫治疗学（Regeneron）主题。这些 产业联系不仅提供了智力资本和资源，而且还提供了一条将发现从 NBC实验室到一个更大的竞技场，在那里他们可以为人类健康和福利做出贡献。额外 优势来自与国家和国际公共卫生机构的关系， 访问见解和临床材料（如诊断样本和PBMC），使工作能够 否则就不追究了。核心设施将包括蛋白质表达，动物模型和蛋白质组学。 我们还将投资于发展项目（创新试点项目）和职业发展， 包括个人和团体职业发展奖励的培训计划。作为一个中心， 公共卫生学院和一个国家卫生部，全国广播公司有一个坚定的承诺和实际的 了解应急准备。

The Northeast Biodefense Center (NBC) is a consortium of >350 investigators in 28 academic and research institutions (many of them in close proximity to one another in the greater NYC metro area), and 13 USbased governmental and international organizations. Over the past 5 years, NBC investigators have demonstrated their commitment to working together across disciplines and institutional boundaries in research and training programs focused on biodefense and emerging infectious diseases as well as emergency preparedness. Evidence of productivity includes >160 publications, 15 invention disclosures, 13 patent applications and 5 licenses for product development. This renewal will comprise 42 investigators and 32 research projects organized into 6 scientific theme areas: Passive Immunotherapeutics (chair: Arturo Casadevall, Einstein); Vaccines (chair: John Rose, Yale); Diagnostics and Pathogen Discovery (chair: Ian Lipkin, Columbia); Therapeutics (chairs: Charles Rice, Rockefeller and Howard Shuman, Columbia,); Innate Immunity (chairs: David Levy, NYU, and Adolfo Garcia-Sastre, Sinai), and Microbial Pathogenesis (chairs: Jorge E. Galan, Yale, and Jorge Benach, Stony Book). Biotechnology and pharmaceutical collaborators are represented in the Diagnostics and Pathogen Discovery (Agilent, Akonni, Cepheid, Xynostics, 454 Life Sciences), Therapeutics (Prosetta, Snowdon), and Passive Immunotherapeutics (Regeneron) themes. These industrial links provide not only intellectual capital and resources but also a path for moving discoveries from NBC laboratories to a larger arena where they can contribute to human health and welfare. Additional strength derives from relationships with national and international public health agencies that provide unique access to insights and clinical materials (such as diagnostic samples and PBMC) that enable work that could not otherwise be pursuec. Core facilities will include Protein Expression, Animal Models, and Proteomics. We will also invest in Developmental Projects (innovative pilot projects) and in Career Development and Training Programs that include individual and group career development awards. As a Center based in a School of Public Health and a State Department of Health, the NBC has a firm commitment to and practical understanding of Emergency Preparedness.