Amyloid-beta Peptides, Depression and Alzheimer's Disease

β 淀粉样肽、抑郁症和阿尔茨海默病

• 批准号: 8284382
• 负责人: WEI QIAO Wendy QIU
• 金额: $ 40.05万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-15 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8284382
• 关键词: Alzheimer' s Disease; Amyloid; Amyloid beta-Protein; Biological Markers; Cerebrospinal Fluid; Creatinine; Critiques; Education; Ethnic Origin; Gender; Impaired cognition; Language; Memory; Mental Depression; Neurobehavioral Manifestations; Neurology; Neuropsychology; Plasma; Staging; Stroke; Subgroup; mortality; tau Proteins

BothAlzheimer'sdisease(AD)anddepressionhavebecomeincreasinglymoreprevalentin thehomeboundelderly,leadingtoincreasedratesofmorbidity,nursinghomeplacementand mortality,thanwhatarefoundinthegeneralelderlypopulation.Ourcross!sectionalstudyofan establishedhomeboundpopulationintheBostonareahasfoundthatlowplasmaamyloid!b42 (Ab42)isassociatedwithdepressionindependentlyofcardiovasculardisease.Wefurther foundthatdepressionwithlowAb42combinedwithhighAb40inplasmaisassociatedwith poormemory.SimilarlyotherresearchstudieshaveshownthatahighplasmaA¿40/A¿42 ratiosignificantlyincreasedtheriskofAD.MultiplestudiesdemonstratethatplasmaA¿ correlateswithcerebralspinalfluid(CSF)A¿whencognitionisnormal,butthisequilibrium disappearsaftertheADcognitivesymptomsoccur.Wehypothesizetheexistenceofa potentialdepressionsubtypeassociatedwithAbpeptidesinplasma,whichwehavetermed "amyloid!associateddepression".ThepurposeofthisR01applicationistovalidatethe existenceofamyloid!associateddepressiondefinedbyahighplasmaA¿40/A¿42ratio,andto investigatewhetherthisdepressionsubtypeisaprodromaldepressionofAD.Theproposalis basedonourestablishedpopulation,andhastwoaims:Aim1istodocumentmemorydecline prospectivelyinthosewithamyloid!associateddepressionvs.thosewithnon!amyloid depressionvs.thecontrols.Aim2istoinvestigatetherelationshipbetweenplasmaA¿and CSFA¿,acentralnervoussystem(CNS)biomarkerofAD,inthedifferentdepression subgroups.Ourlong!termgoalistoidentifyprodromalsignsofADtohelpfacilitateearly treatmentofthediseaseinthehomeboundelderlypopulation.

BothAlzheimer‘sdisease(AD)anddepressionhavebecomeincreasinglymoreprevalentin 家庭受到束缚，导致发病率、护理和家庭安置增加 死亡率，thanwhatarefoundinthegeneralelderlypopulation.Ourcross！sectionalstudyofan EstablishedhomeboundpopulationintheBostonareahasfoundthatlowplasmaamyloid！b42 (Ab42)isassociatedwithdepressionindependentlyofcardiovasculardisease.Wefurther FoundthatdepressionwithlowAb42combinedwithhighAb40inplasmaisassociatedwith Poormemory.SimilarlyotherresearchstudieshaveshownthatahighplasmaA¿40/A¿42 RatiosignificantlyincreasedtheriskofAD.MultiplestudiesdemonstratethatplasmaA¿ Correlateswithcerebralspinalfluid(CSF)A¿whencognitionisnormal，平衡 DisappearsaftertheADcognitivesymptomsoccur.Wehypothesizetheexistenceofa 我们已经退役的potentialdepressionsubtypeassociatedwithAbpeptidesinplasma， “amyloid！associateddepression”.ThepurposeofthisR01applicationistovalidatethe Existenceofamyloid！associateddepressiondefinedbyahighplasmaA¿40/A¿42ratio，和TO InvestigatewhetherthisdepressionsubtypeisaprodromaldepressionofAD.Theproposalis 基于可恢复的人口，并有一个目标：Aim1记录的记忆力下降 Prospectivelyinthosewithamyloid！associateddepressionvs.thosewithnon！amyloid Depressionvs.thecontrols.Aim2istoinvestigatetherelationshipbetweenplasmaA¿and 阿尔茨海默病的中枢神经系统生物标志物CSFA在不同抑郁症中的作用 Subgroups.Ourlong！termgoalistoidentifyprodromalsignsofADtohelpfacilitateearly Treatmentofthediseaseinthehomeboundelderlypopulation.