Plasma Amyloid-beta Peptides, Depression and Alzheimer's Disease in the Homebound

阿尔茨海默病（AD）和抑郁症的发病率都在不断增加， 居家养老导致发病率上升，居家养老 死亡率比一般老年人要高。我们的十字架！分段研究 在波士顿地区建立的家庭人口发现低血浆淀粉样蛋白！B42 （Ab 42）与抑郁症相关，与心血管疾病无关。 发现血浆中低Ab 42结合高Ab 40的抑郁症与 记忆力差。类似地，其他研究表明，高血浆A <$40/A <$42 比率显著增加AD的风险。多项研究表明， 与脑脊液（CSF）A相关，当妊娠正常时，但这种平衡 在AD认知症状发生后消失。我们假设存在一个 与血浆中的Ab肽相关的潜在抑郁亚型， “淀粉样蛋白！本R 01申请的目的是验证 淀粉样蛋白的存在！伴发抑郁症，由高血浆A <$40/A <$42比值定义， 研究这种抑郁亚型是否是AD的前驱抑郁症。 根据我们建立的人口，并已目标：目标1是文件内存下降 有淀粉样蛋白的人！相关抑郁症vs.那些没有！淀粉样 目的2是研究血浆A和 CSFA？，AD的中枢神经系统（CNS）标记物，在不同抑郁症中 分组。我们的！术语目标是识别AD的前驱信号以帮助尽早提供帮助 在本土人群中治疗这种疾病。

BothAlzheimer'sdisease(AD)anddepressionhavebecomeincreasinglymoreprevalentin thehomeboundelderly,leadingtoincreasedratesofmorbidity,nursinghomeplacementand mortality,thanwhatarefoundinthegeneralelderlypopulation.Ourcross!sectionalstudyofan establishedhomeboundpopulationintheBostonareahasfoundthatlowplasmaamyloid!b42 (Ab42)isassociatedwithdepressionindependentlyofcardiovasculardisease.Wefurther foundthatdepressionwithlowAb42combinedwithhighAb40inplasmaisassociatedwith poormemory.SimilarlyotherresearchstudieshaveshownthatahighplasmaA¿40/A¿42 ratiosignificantlyincreasedtheriskofAD.MultiplestudiesdemonstratethatplasmaA¿ correlateswithcerebralspinalfluid(CSF)A¿whencognitionisnormal,butthisequilibrium disappearsaftertheADcognitivesymptomsoccur.Wehypothesizetheexistenceofa potentialdepressionsubtypeassociatedwithAbpeptidesinplasma,whichwehavetermed "amyloid!associateddepression".ThepurposeofthisR01applicationistovalidatethe existenceofamyloid!associateddepressiondefinedbyahighplasmaA¿40/A¿42ratio,andto investigatewhetherthisdepressionsubtypeisaprodromaldepressionofAD.Theproposalis basedonourestablishedpopulation,andhastwoaims:Aim1istodocumentmemorydecline prospectivelyinthosewithamyloid!associateddepressionvs.thosewithnon!amyloid depressionvs.thecontrols.Aim2istoinvestigatetherelationshipbetweenplasmaA¿and CSFA¿,acentralnervoussystem(CNS)biomarkerofAD,inthedifferentdepression subgroups.Ourlong!termgoalistoidentifyprodromalsignsofADtohelpfacilitateearly treatmentofthediseaseinthehomeboundelderlypopulation.