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Pilot 3 - Developmental Exposure Alcohol Research Center

Pilot 3 - Developmental Exposure Alcohol Research Center
试点 3 - 发育性暴露酒精研究中心
批准号：
8381966
负责人：
Sandra M Mooney
金额：
$2.21万
依托单位：
STATE UNIVERSITY OF NY,BINGHAMTON
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8381966
关键词：
AcuteAdolescenceAffectAgeAmygdaloid structureAnimalsBehaviorBiological ProcessBrainBrain regionCellsCharacteristicsDataDevelopmentDevelopmental ProcessDoseEthanolEtiologyExposure toFetal Alcohol Spectrum DisorderFetal Alcohol SyndromeGenerationsGrowthHippocampus (Brain)Infusion proceduresMedialNeurobiologyNeurologicNeuronsOutcomeOxytocinPlayPrefrontal CortexRoleSocial BehaviorStructureSystemTestingTimealcohol effectalcohol researchbasebehavior testcraniofacialdevelopmental diseaseearly adolescencegastrulationmalemalformationmigrationneuronal survivaloffspringprenatal exposuresocialtranscriptional coactivator p75young adult

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中文摘要
翻译
社会行为受到产前酒精暴露的影响。杏仁核中的催产素系统被认为 在社会行为中发挥重要作用。我们将检验在原肠发育过程中急性暴露的假设 (妊娠第7天)或在杏仁核神经元生成期间(G14)将导致显著的 社交行为缺陷。G7或G14将给动物注射乙醇。后代将经历社会行为 测试后，将收集大脑，以分析酒精对杏仁核的影响。这些研究将 提供与产前酒精暴露相关的社会行为缺陷的病因学有价值的数据 并将开始研究这种赤字背后的机制(S)。
英文摘要
Social behavior is affected by prenatal exposure to ethanol. The oxytocin system in the amygdala is thought to play a major role in social behavior. We will test the hypothesis that acute exposure during gastrulation (gestational day (G) 7) or during the time of generation of amygdala neurons (G14) will result in a significant deficit in social behavior. Animals will be given ethanol on G7 or G14. Offspring will undergo social behavior testing then the brains will be collected for analysis of the effect of ethanol on the amygdala. These studies will provide valuable data on the etiology of the social behavior deficits associated with prenatal exposure to ethanol and will begin to examine the mechanism(s) underlying such deficits.
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会议论文
Model of Fetal Alcohol Spectrum Disorder
  • 批准号：
    9260215
  • 项目类别：
  • 资助金额：
    $37.58万
  • 财政年份：
    2017
  • 负责人：
    Sandra M Mooney
  • 依托单位：
    UNIVERSITY OF MARYLAND BALTIMORE
Nutrient combination to mitigate Fetal Alcohol Spectrum Disorder
Model of Fetal Alcohol Spectrum Disorder
Model of Fetal Alcohol Spectrum Disorder
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