2012 Angiotensin Gordon Research Conference and Gordon Research Seminar

描述(由申请者提供)：2012年血管紧张素-戈登研究会议(GRC)和连续的戈登研究研讨会(GRS)将聚焦于肾素血管紧张素系统(RAS)的关键未发表进展，涵盖血管生成、癌症风险、RAS结构生物学、新的信号机制、干细胞功能和不同的主动脉病理。主题将包括microRNA，内分泌RAS和表观遗传学，以及在较少研究的目标组织，如脂肪和骨骼肌中RAS的调节。会议将介绍新的成像和分子技术，包括生物发光、共振、能量转移和纳米技术。此外，还将讨论关于RAS级联中最不了解的成员的最新发现，包括蛋白质受体、氨基肽酶A和糜酶，以及RAS的新治疗靶点，包括癌症、抑郁症和多发性硬化症。GRS将与GRC接轨，主要关注RAS在发育、免疫和炎症方面的作用。GRC和GRS的主要目标是：1)批判性地检查尖端未发表的数据，这些数据将基础科学与RAS的临床和翻译研究交织在一起；2)让所有参与者自由、坦率和分析地讨论研究结果，并在科学会议期间以及在用餐、休息、休闲和社会活动中对未来的影响进行创造性的推测；3)促进新的合作和跨学科的研究计划 生物化学、分子和细胞生物学、神经科学、生理学和人类病理生理学等学科；4)通过在GRC的海报会议、简短演讲和旅行获奖比赛以及GRS(由学生、实习生和青年研究人员组织并专门以学生、实习生和青年研究人员为特色)提供提高知名度的机会，促进学生、实习生和早期职业调查人员的独立科学职业生涯。

DESCRIPTION (provided by applicant): The 2012 Angiotensin Gordon Research Conference (GRC) and contiguous Gordon Research Seminar (GRS) will focus on key unpublished developments in the renin angiotensin system (RAS) covering angiogenesis, cancer risk, RAS structural biology, novel signaling mechanisms, stem cell function and diverse aortic pathologies. Topics will include microRNA, the intracrine RAS and epigenetics and also regulation of the RAS in less studied target tissues such as adipose and skeletal muscle. New insights from novel imaging and molecular techniques including bioluminescence resonance energy transfer and nanotechnology will be presented. In addition, the latest findings on the least understood members of the RAS cascade including the protein receptor, aminopeptidase A, and chymase will be discussed as well as novel therapeutic targets of the RAS including cancer, depression and multiple sclerosis. The GRS will dovetail to the GRC and will primarily focus on the RAS in development, immunity and inflammation. The primary goals of the GRC and GRS are to: 1) critically examine cutting-edge unpublished data that intertwines basic science with clinical and translational research on the RAS; 2) engage all participants in unfettered frank and analytical discussion of research findings and creative speculation over future implications during the scientific sessions as well as at meals, breaks, and leisure and social activities; 3) foster new collaborative and cross-disciplinary research initiatives spanning the disciplines of biochemistry, molecular and cellular biology, neuroscience, physiology and human pathophysiology; 4) advance the independent scientific careers of students, trainees and early career investigators by providing visibility opportunities through poster sessions, short talks and travel award competitions at the GRC and through the GRS, which is organized by and specifically features students, trainees and young investigators.