IGRT SOFTWARE SOFTWARE USING IN VIVO OPTICAL 3D & CBCT IMAGES

在SBIR中，Xigen提出开发一套新颖的3D配准算法和图像引导放射治疗（IGRT）软件包。该新型软件协同地将锥形束计算机断层扫描（CBCT）相位分箱（或振幅分箱）的体积3D图像与实时光学3D（O3 D）表面图像相关联，以（近）实时地提供治疗位置中的患者的治疗目标和周围解剖结构的体内准确体积3D位置。 CBCT可以在IGRT会话之前提供患者解剖结构的体积3D/4D图像。然而，由于采集速度和辐射暴露，CBCT不适合在实时患者监测中连续使用。相比之下，光学3D表面成像可以在体内连续进行，而无需任何电离辐射。然而，它不能提供内部解剖结构信息。本文提出的创新方法继承了CBCT和光学3D表面成像两者的优点，同时减轻了两者的缺点。它有望为IGRT提供可行的体内解决方案，以显著减少放射治疗（RT）所有三个阶段的错误：（1）治疗计划;（2）患者治疗设置;以及（3）适应分次间解剖变化和分次内运动。 据Xigen所知，没有现有技术可以为IGRT实现类似的实时表面体积3D成像性能。

In this SBIR, Xigen proposes to develop a set of novel 3D registration algorithms and a software package for image-guided radiotherapy (IGRT). This novel software synergistically correlates cone-beam computed tomography (CBCT) phase-binned (or amplitude-binned) volumetric 3D images with real-time optical 3D (O3D) surface images to provide in-vivo accurate volumetric 3D location of the treatment target and surrounding anatomy of the patient in the treatment position in (near) real-time. CBCT can provide volumetric 3D/4D images of patient¿s anatomy prior to an IGRT session. However, due to acquisition speed and radiation exposure, CBCT is not suitable for continuous use in real-time patient monitoring. In contrast, optical 3D surface imaging can be performed in-vivo and continuously without any ionizing radiation. It however is not able to provide internal anatomy information. The innovative approach proposed herein inherits advantages of both the CBCT and the optical 3D surface imaging, while alleviating drawbacks of both. It promises to provide viable in-vivo solution to IGRT for significantly reducing errors in all three stages of radiation therapy (RT): (1) treatment planning; (2) patient setup for treatment; and (3) adaptation to inter-fractional anatomic changes and intra-fractional movement. To the best of Xigen's knowledge, there is no existing technology that can achieve similar performance of real-time surface-volumetric 3D imaging for IGRT.