Integrated Clinical Neuroscience Training for Translational Research

描述(由申请者提供)：翻译研究代表了促进所有形式的精神病理学知识的一个主要倡议。这项工作包括将动物正常和异常行为背后的神经机制转化为精神障碍的原因和治疗的临床研究。然而，神经科学和临床心理学的博士培训与课程要求、实验室经验和接触外部演讲者的分离，阻碍了新科学家在自己的研究中采取翻译方法的准备。拟议的综合临床神经科学(ICN)培训计划的广泛和长期目标是培训下一代研究人员成为翻译研究的领导者，他们将在精神病理学的几个领域做出关键贡献，这些领域的特征是失调(“失禁”)行为，包括进食障碍、自杀、精神变态和外化谱系障碍。这些问题与严重的心理和医疗发病率、较高的死亡率和沉重的经济负担有关，突显了翻译方法的必要性。ICN培训计划将通过以下几个部分为4名在佛罗里达州立大学获得临床心理学和神经科学博士学位的博士前实习生提供综合指导和监督：1)跨区域课程，2)跨区域实验室轮换以进行协作的跨领域论文研究，3)特别演讲者系列，在该系列演讲中，进行翻译工作的国家学者将向学员介绍他们的研究，学员将向特邀演讲者、ICN培训教师、系和社区介绍他们正在进行的研究，4)在会议和发表的论文中展示研究成果，以及5)拨款撰写方面的指导，以及负责任的研究实施方面的额外(跨领域)指导。博士前实习生将申请ICN培训计划，描述他们计划与主要导师和跨领域导师合作进行的研究，他们将完成的课程，以及ICN培训计划将如何促进他们作为翻译科学家的职业发展。ICN培训人员来自临床和神经科学项目，该项目基于解决失调行为的研究中的跨区域联系。受训者将在第三或第四年开始时被任命，以确保挑选出最有前途的受训者，这些受训者已经完成了基本计划要求，并在他们的主要顾问实验室建立了研究，他们可以通过跨区域实验室轮换来扩展工作。支持期限为2年。这一时间和持续时间优化了完成论文研究的培训补助金支持的好处。培训人员在为NIH提供资金和培训学生从事富有成效的研究职业方面有着良好的记录。拟议的培训拨款将建立在这一成功的基础上，确保新的博士生在开发独立的研究项目以解决以行为失调为特征的精神障碍时，能够理想地启动尖端翻译研究。 公共卫生相关性：以饮食失调、自杀、精神变态和相关障碍等行为失调为特征的精神问题会造成情感和身体上的痛苦，并与高昂的医疗费用和增加自我(饮食障碍和自杀)和他人(精神变态和相关障碍)的死亡风险有关。拟议的培训计划将培训下一代研究人员进行转化性研究，以解决这些障碍，并减少与障碍相关的痛苦、经济负担和死亡率。

DESCRIPTION (provided by applicant): Translational research represents a major initiative for advancing knowledge of all forms of psychopathology. This work includes translating the neural mechanisms that underlie normal and abnormal behavior in animals into clinical studies of the causes and treatment of mental disorders. However, segregation of doctoral training in Neuroscience and Clinical Psychology, with separate course requirements, lab experiences, and exposure to outside speakers, impedes new scientists' preparation to undertake translational approaches in their own research. The broad, long-term objectives of the proposed Integrated Clinical Neuroscience (ICN) Training Program are to train the next generation of researchers to become leaders in translational research who will make key contributions across several areas of psychopathology characterized by dysregulated ("disinhibited") behaviors including eating disorders, suicidality, psychopathy, and externalizing spectrum disorders. These problems are associated with significant psychological and medical morbidity, elevated mortality, and high economic burden, underscoring the need for translational approaches. The ICN Training Program will provide integrated instruction and supervision to 4 predoctoral trainees earning Ph.D.s in Clinical Psychology and Neuroscience at Florida State University through several components: 1) cross-area courses, 2) cross-area lab rotations to conduct collaborative, cross-area dissertation research, 3) a Special Speaker Series in which national scholars conducting translational work will present their research to trainees, and trainees will present their ongoing research to invited speakers, ICN training faculty, the Department, and community, 4) presentation of research at conferences and in published papers, as well as 5) instruction in grant writing and additional (cross-area) instruction in the responsible conduct of research. Predoctoral trainees will apply for the ICN Training Program by describing research they plan to conduct in collaboration with their primary advisor and cross-area mentor, classes they will complete, and how the ICN Training Program will contribute to their career development as translational scientists. ICN training faculty come from the Clinical and Neuroscience programs based on cross-area connections in research addressing dysregulated behaviors. Trainees will be appointed at the beginning of their third or fourth year to ensure selection of the most promising trainees who have completed basic program requirements and have established research in their primary advisor's lab that they can extend through work in a cross-area lab rotation. The duration of support will be 2 years. This timing and duration optimize benefit of training grant support for completion of dissertation research. Training facult have strong track records of NIH funding and in training students for productive research careers. The proposed training grant will build upon this success by ensuring that new Ph.D. students are ideally positioned to initiate cutting-edge translational research as they develop independent programs of research to address mental disorders characterized by dysregulated behaviors. PUBLIC HEALTH RELEVANCE: Mental problems characterized by dysregulated behaviors such as eating disorders, suicidality, psychopathy, and related disorders contribute to emotional and physical suffering and are associated with high healthcare costs and increased risk of death to the self (eating disorders and suicidality) and others (psychopathy and related disorders). The proposed training program will train the next generation of researchers to pursue translational research to address these disorders and reduce disorder-related suffering, economic burden, and mortality.