Integrated Clinical Neuroscience Training for Translational Research

描述（由申请人提供）：转化研究代表了推进所有形式精神病理学知识的主要举措。这项工作包括将动物正常和异常行为背后的神经机制转化为精神障碍病因和治疗的临床研究。然而，神经科学和临床心理学的博士培训分离，有不同的课程要求，实验室经验和接触外部演讲者，阻碍了新科学家在自己的研究中采取转化方法的准备。拟议的综合临床神经科学（ICN）培训计划的广泛、长期目标是培养下一代研究人员成为转化研究的领导者，他们将在以失调（“去抑制”）行为为特征的精神病理学几个领域做出关键贡献，包括饮食失调、自杀、精神病和外化谱系障碍。这些问题与严重的心理和医疗发病率、高死亡率和高经济负担有关，强调需要采用转化方法。ICN培训计划将通过以下几个部分为4名在佛罗里达州立大学获得临床心理学和神经科学博士学位的博士前学员提供综合指导和监督：1)跨领域课程，2)跨领域实验室轮转，开展合作，跨领域的论文研究，3)特别演讲系列，其中进行翻译工作的国家学者将向学员介绍他们的研究，学员将向邀请演讲者，ICN培训教师，部门和社区介绍他们正在进行的研究，4)在会议和发表的论文中介绍研究。以及5)拨款写作的指导和负责任的研究行为的额外（跨领域）指导。博士预科学员申请ICN培训计划时，需要描述他们计划与主要顾问和跨领域导师合作开展的研究、他们将完成的课程，以及ICN培训计划将如何促进他们作为转化科学家的职业发展。ICN培训教师来自临床和神经科学项目，基于跨领域联系的研究，解决失调行为。学员将在第三或第四年开始时被任命，以确保选择最有前途的学员，这些学员已经完成了基本的项目要求，并在其主要导师的实验室中建立了研究成果，他们可以通过跨区域实验室轮转工作来扩展。支持期限为2年。这个时间和持续时间优化培训补助金支持完成论文研究的利益。培训教师在NIH资助和培养学生从事生产性研究事业方面有着良好的记录。拟议的培训补助金将在这一成功的基础上，确保新的博士生在开发以行为失调为特征的精神障碍的独立研究项目时，能够理想地开展尖端的转化研究。

DESCRIPTION (provided by applicant): Translational research represents a major initiative for advancing knowledge of all forms of psychopathology. This work includes translating the neural mechanisms that underlie normal and abnormal behavior in animals into clinical studies of the causes and treatment of mental disorders. However, segregation of doctoral training in Neuroscience and Clinical Psychology, with separate course requirements, lab experiences, and exposure to outside speakers, impedes new scientists' preparation to undertake translational approaches in their own research. The broad, long-term objectives of the proposed Integrated Clinical Neuroscience (ICN) Training Program are to train the next generation of researchers to become leaders in translational research who will make key contributions across several areas of psychopathology characterized by dysregulated ("disinhibited") behaviors including eating disorders, suicidality, psychopathy, and externalizing spectrum disorders. These problems are associated with significant psychological and medical morbidity, elevated mortality, and high economic burden, underscoring the need for translational approaches. The ICN Training Program will provide integrated instruction and supervision to 4 predoctoral trainees earning Ph.D.s in Clinical Psychology and Neuroscience at Florida State University through several components: 1) cross-area courses, 2) cross-area lab rotations to conduct collaborative, cross-area dissertation research, 3) a Special Speaker Series in which national scholars conducting translational work will present their research to trainees, and trainees will present their ongoing research to invited speakers, ICN training faculty, the Department, and community, 4) presentation of research at conferences and in published papers, as well as 5) instruction in grant writing and additional (cross-area) instruction in the responsible conduct of research. Predoctoral trainees will apply for the ICN Training Program by describing research they plan to conduct in collaboration with their primary advisor and cross-area mentor, classes they will complete, and how the ICN Training Program will contribute to their career development as translational scientists. ICN training faculty come from the Clinical and Neuroscience programs based on cross-area connections in research addressing dysregulated behaviors. Trainees will be appointed at the beginning of their third or fourth year to ensure selection of the most promising trainees who have completed basic program requirements and have established research in their primary advisor's lab that they can extend through work in a cross-area lab rotation. The duration of support will be 2 years. This timing and duration optimize benefit of training grant support for completion of dissertation research. Training facult have strong track records of NIH funding and in training students for productive research careers. The proposed training grant will build upon this success by ensuring that new Ph.D. students are ideally positioned to initiate cutting-edge translational research as they develop independent programs of research to address mental disorders characterized by dysregulated behaviors. PUBLIC HEALTH RELEVANCE: Mental problems characterized by dysregulated behaviors such as eating disorders, suicidality, psychopathy, and related disorders contribute to emotional and physical suffering and are associated with high healthcare costs and increased risk of death to the self (eating disorders and suicidality) and others (psychopathy and related disorders). The proposed training program will train the next generation of researchers to pursue translational research to address these disorders and reduce disorder-related suffering, economic burden, and mortality.