Integrated Clinical Neuroscience Training for Translational Research

转化研究综合临床神经科学培训

• 批准号: 8672676
• 负责人: LISA A ECKEL
• 金额: $ 12.07万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8672676
• 关键词: Clinical; Neurosciences; Training; Translational Research

DESCRIPTION (provided by applicant): Translational research represents a major initiative for advancing knowledge of all forms of psychopathology. This work includes translating the neural mechanisms that underlie normal and abnormal behavior in animals into clinical studies of the causes and treatment of mental disorders. However, segregation of doctoral training in Neuroscience and Clinical Psychology, with separate course requirements, lab experiences, and exposure to outside speakers, impedes new scientists' preparation to undertake translational approaches in their own research. The broad, long-term objectives of the proposed Integrated Clinical Neuroscience (ICN) Training Program are to train the next generation of researchers to become leaders in translational research who will make key contributions across several areas of psychopathology characterized by dysregulated ("disinhibited") behaviors including eating disorders, suicidality, psychopathy, and externalizing spectrum disorders. These problems are associated with significant psychological and medical morbidity, elevated mortality, and high economic burden, underscoring the need for translational approaches. The ICN Training Program will provide integrated instruction and supervision to 4 predoctoral trainees earning Ph.D.s in Clinical Psychology and Neuroscience at Florida State University through several components: 1) cross-area courses, 2) cross-area lab rotations to conduct collaborative, cross-area dissertation research, 3) a Special Speaker Series in which national scholars conducting translational work will present their research to trainees, and trainees will present their ongoing research to invited speakers, ICN training faculty, the Department, and community, 4) presentation of research at conferences and in published papers, as well as 5) instruction in grant writing and additional (cross-area) instruction in the responsible conduct of research. Predoctoral trainees will apply for the ICN Training Program by describing research they plan to conduct in collaboration with their primary advisor and cross-area mentor, classes they will complete, and how the ICN Training Program will contribute to their career development as translational scientists. ICN training faculty come from the Clinical and Neuroscience programs based on cross-area connections in research addressing dysregulated behaviors. Trainees will be appointed at the beginning of their third or fourth year to ensure selection of the most promising trainees who have completed basic program requirements and have established research in their primary advisor's lab that they can extend through work in a cross-area lab rotation. The duration of support will be 2 years. This timing and duration optimize benefit of training grant support for completion of dissertation research. Training facult have strong track records of NIH funding and in training students for productive research careers. The proposed training grant will build upon this success by ensuring that new Ph.D. students are ideally positioned to initiate cutting-edge translational research as they develop independent programs of research to address mental disorders characterized by dysregulated behaviors.

描述（由申请人提供）：转化研究代表了推进所有形式的精神病理学知识的主要举措。这项工作包括将动物正常和异常行为背后的神经机制转化为精神障碍的原因和治疗的临床研究。然而，神经科学和临床心理学博士培训的隔离，具有单独的课程要求，实验室经验和接触外部演讲者，阻碍了新科学家在自己的研究中进行转化方法的准备。拟议的综合临床神经科学（ICN）培训计划的广泛，长期目标是培养下一代研究人员成为转化研究的领导者，他们将在精神病理学的几个领域做出关键贡献，这些领域的特点是失调（“去抑制”）行为，包括饮食失调，自杀，精神病和外化谱系障碍。这些问题与显著的心理和医学发病率，死亡率升高，高经济负担，强调需要转化的方法。ICN培训计划将通过以下几个组成部分为4名在佛罗里达州立大学获得临床心理学和神经科学博士学位的博士前学员提供综合指导和监督：1）跨领域课程，2）跨领域实验室轮换进行合作，跨领域论文研究，3）特别演讲者系列，其中进行翻译工作的国家学者将向学员介绍他们的研究，和学员将介绍他们正在进行的研究，邀请演讲者，ICN培训教师，部门和社区，4）在会议上和发表的论文中介绍研究，以及5）在授权写作和额外的指令（跨领域）指令在负责任的研究行为。博士前学员将通过描述他们计划与他们的主要顾问和跨领域导师合作进行的研究，他们将完成的课程，以及ICN培训计划将如何有助于他们作为翻译科学家的职业发展来申请ICN培训计划。ICN培训教师来自临床和神经科学项目，这些项目基于解决失调行为的研究中的跨领域联系。学员将在第三年或第四年开始时被任命，以确保选择最有前途的学员，他们已经完成了基本的课程要求，并在他们的主要顾问的实验室建立了研究，他们可以通过跨区域实验室轮换的工作来扩展。支持期限为2年。这一时间安排和持续时间优化了培训补助金对完成论文研究的支持。培训学院在NIH资助和培训学生从事生产性研究方面有着良好的记录。拟议的培训补助金将建立在这一成功的基础上，确保新的博士学位。学生的理想定位，以启动尖端的转化研究，因为他们开发的研究，以解决由失调行为的特点精神障碍的独立方案。