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Integrated Clinical Neuroscience Training for Translational Research

转化研究综合临床神经科学培训

基本信息

批准号：
10595611
负责人：
LISA A ECKEL
金额：
$ 17.08万
依托单位：
FLORIDA STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-01 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10595611
关键词：
Clinical Neurosciences Training Translational Research

项目摘要

The Integrated Clinical Neuroscience (ICN) Training Program, operating within the Clinical Psychology and interdisciplinary Neuroscience programs at Florida State University for the past 9 years, seeks to train the next generation of investigators to become leaders in translational research and make major advances in several areas of psychopathology characterized by dysregulated behaviors including eating disorders, depression, anxiety disorders, suicidality, post-traumatic stress disorder, and substance use disorders. These problems are associated with significant psychological and medical morbidity, elevated mortality, and high economic burden. This underscores the need for research that translates the neural mechanisms underlying normal and abnormal behavior in animals into clinical studies of the causes and treatment of mental disorders. However, segregation of doctoral training in Clinical Psychology and Neuroscience, with separate courses, lab experiences, and exposure to outside speakers, impedes new scientists’ preparation to undertake translational approaches in their own research. The ICN Training Program was designed to break down these barriers. Here, we seek continued funding to provide integrated instruction, research experience, and mentorship to 4 predoctoral ICN trainees earning PhDs in Clinical Psychology and Neuroscience through 1) cross-area courses, 2) cross-area lab rotations, 3) a Special Speaker Series in which trainees present their research to invited scholars conducting translational science, and these scholars present their work to trainees, our participating Departments, and the community, 4) presentation of research at conferences and in published papers, and 5) instruction in grant writing, data science, and cross-area instruction in the responsible conduct of research. Predoctoral trainees apply for the ICN Training Program by describing research they plan to conduct in collaboration with their primary advisor and cross-area mentor, classes they will complete, and how this cross-area exposure will contribute to their career development as translational scientists. Students are typically appointed for two years beginning in their 3rd to 4th year to ensure selection of the most promising trainees who have completed basic program requirements and established research interests that can be extended by a cross-area lab rotation. Our training model has supported a total of 19 trainees. Among the 13 ICN trainees who have completed the Ph.D., 92% have continued in research careers (with 4 currently in tenure-track positions) and 77% have received highly competitive fellowships and independent research grants. Training faculty, selected for their cross-area connections in research addressing dysregulated behaviors, continue to excel in securing grant funding and training students for research careers with strong publication records. Continuation of the ICN Training Grant for an additional 5 years will build upon our accomplishments and ensure that a third cohort of Ph.D. students is ideally positioned to initiate cutting-edge translational research to address mental disorders characterized by dysregulated behaviors.

综合临床神经科学（ICN）培训计划，在临床心理学和在过去的9年里，佛罗里达州立大学的跨学科神经科学项目旨在培养下一个一代研究人员成为转化研究的领导者，并在几个方面取得重大进展以失调行为为特征的精神病理学领域，包括饮食失调，抑郁症，焦虑症、自杀倾向、创伤后应激障碍和物质使用障碍。这些问题与显著的心理和医学发病率、死亡率升高和高经济负担相关。这强调了研究的必要性，这些研究将正常和动物的异常行为纳入临床研究的原因和治疗精神疾病。然而，在这方面，临床心理学和神经科学博士培训的分离，有单独的课程，实验室经验和接触外部演讲者，阻碍了新科学家进行翻译的准备。在自己的研究中。国际竞争网络培训方案旨在打破这些障碍。在这里，我们寻求持续的资金，以提供综合教学，研究经验，并指导4 通过1）跨领域获得临床心理学和神经科学博士学位的博士前ICN学员课程，2）跨区域实验室轮换，3）特别演讲者系列，其中学员介绍他们的研究，邀请学者进行翻译科学，这些学者向学员介绍他们的工作，我们的参与部门和社区，4）在会议上和出版的研究报告论文，以及5）拨款写作，数据科学和责任行为跨区域教学的指导的研究。博士前学员通过描述他们计划进行的研究来申请ICN培训计划。与他们的主要顾问和跨领域导师合作进行，他们将完成的课程，以及如何这种跨领域的接触将有助于他们作为翻译科学家的职业发展。学生通常从第三年到第四年开始任命两年，以确保选出最有前途的人。学员谁已经完成了基本的程序要求，并建立了研究兴趣，可以通过跨区域的实验室轮换来扩展。我们的培训模式共为19名学员提供了支持。在13个已完成博士学位的ICN学员，92%的人继续从事研究工作（其中4人目前在终身职位），77%获得了极具竞争力的奖学金和独立研究赠款。培训教师，选择他们在研究解决失调的跨区域连接行为，继续在确保赠款资金和培训学生的研究生涯与强大的出版记录。国际竞争网络培训补助金将再延续5年，成就，并确保第三批博士。学生是理想的定位，以启动尖端转化研究，以解决以行为失调为特征的精神障碍。

项目成果

期刊论文数量（115）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Anxiety sensitivity and suicidal ideation/suicide risk: A meta-analysis.

焦虑敏感性和自杀念头/自杀风险：一项荟萃分析。

DOI：
10.1037/ccp0000342
发表时间：
2018-11
期刊：
Journal of consulting and clinical psychology
影响因子：
5.9
作者：
Stanley IH;Boffa JW;Rogers ML;Hom MA;Albanese BJ;Chu C;Capron DW;Schmidt NB;Joiner TE
通讯作者：
Joiner TE

A randomized clinical trial examining the effects of an anxiety sensitivity intervention on insomnia symptoms: Replication and extension.

一项随机临床试验，研究焦虑敏感性干预对失眠症状的影响：复制和扩展。

DOI：
10.1016/j.brat.2017.09.013
发表时间：
2017
期刊：
Behaviour research and therapy
影响因子：
4.1
作者：
Short,NicoleA;Boffa,JosephW;King,Savannah;Albanese,BrianJ;Allan,NicholasP;Schmidt,NormanB
通讯作者：
Schmidt,NormanB

Do Undiagnosed Suicide Decedents Have Symptoms of a Mental Disorder?